Details

Autor(en) / Beteiligte

• Tosif, Shidan
• Neeland, Melanie R
• Sutton, Philip
• Licciardi, Paul V
• Sarkar, Sohinee
• Selva, Kevin J
• Do, Lien Anh Ha
• Donato, Celeste
• Quan Toh, Zheng
• Higgins, Rachel
• Van de Sandt, Carolien
• Lemke, Melissa M
• Lee, Christina Y
• Shoffner, Suzanne K
• Flanagan, Katie L
• Arnold, Kelly B
• Mordant, Francesca L
• Mulholland, Kim
• Bines, Julie
• Dohle, Kate
• Pellicci, Daniel G
• Curtis, Nigel
• McNab, Sarah
• Steer, Andrew
• Saffery, Richard
• Subbarao, Kanta
• Chung, Amy W
• Kedzierska, Katherine
• Burgner, David P
• Crawford, Nigel W

Titel

Immune responses to SARS-CoV-2 in three children of parents with symptomatic COVID-19

Ist Teil von

• Nature communications, 2020-11, Vol.11 (1), p.5703-5703, Article 5703

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• Compared to adults, children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have predominantly mild or asymptomatic infections, but the underlying immunological differences remain unclear. Here, we describe clinical features, virology, longitudinal cellular, and cytokine immune profile, SARS-CoV-2-specific serology and salivary antibody responses in a family of two parents with PCR-confirmed symptomatic SARS-CoV-2 infection and their three children, who tested repeatedly SARS-CoV-2 PCR negative. Cellular immune profiles and cytokine responses of all children are similar to their parents at all timepoints. All family members have salivary anti-SARS-CoV-2 antibodies detected, predominantly IgA, that coincide with symptom resolution in 3 of 4 symptomatic members. Plasma from both parents and one child have IgG antibody against the S1 protein and virus-neutralizing activity detected. Using a systems serology approach, we demonstrate higher levels of SARS-CoV-2-specific antibody features of these family members compared to healthy controls. These data indicate that children can mount an immune response to SARS-CoV-2 without virological confirmation of infection, raising the possibility that immunity in children can prevent the establishment of SARS-CoV-2 infection. Relying on routine virological and serological testing may not identify exposed children, with implications for epidemiological and clinical studies across the life-span.