Nature communications, 2021-02, Vol.12 (1), p.1282-1282, Article 1282
- Huot, Nicolas
- Rascle, Philippe
- Petitdemange, Caroline
- Contreras, Vanessa
- Stürzel, Christina M
- Baquero, Eduard
- Harper, Justin L
- Passaes, Caroline
- Legendre, Rachel
- Varet, Hugo
- Madec, Yoann
- Sauermann, Ulrike
- Stahl-Hennig, Christiane
- Nattermann, Jacob
- Saez-Cirion, Asier
- Le Grand, Roger
- Keith Reeves, R
- Paiardini, Mirko
- Kirchhoff, Frank
- Jacquelin, Beatrice
- Müller-Trutwin, Michaela
2021
Details
- Autor(en) / Beteiligte
- Huot, Nicolas
- Rascle, Philippe
- Petitdemange, Caroline
- Contreras, Vanessa
- Stürzel, Christina M
- Baquero, Eduard
- Harper, Justin L
- Passaes, Caroline
- Legendre, Rachel
- Varet, Hugo
- Madec, Yoann
- Sauermann, Ulrike
- Stahl-Hennig, Christiane
- Nattermann, Jacob
- Saez-Cirion, Asier
- Le Grand, Roger
- Keith Reeves, R
- Paiardini, Mirko
- Kirchhoff, Frank
- Jacquelin, Beatrice
- Müller-Trutwin, Michaela
- Titel
- SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity
- Ist Teil von
- Nature communications, 2021-02, Vol.12 (1), p.1282-1282, Article 1282
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2021
- Link zum Volltext
- Quelle
- Alma/SFX Local Collection
- Beschreibungen/Notizen
- Natural killer (NK) cells play a critical understudied role during HIV infection in tissues. In a natural host of SIV, the African green monkey (AGM), NK cells mediate a strong control of SIVagm infection in secondary lymphoid tissues. We demonstrate that SIVagm infection induces the expansion of terminally differentiated NKG2a NK cells in secondary lymphoid organs displaying an adaptive transcriptional profile and increased MHC-E-restricted cytotoxicity in response to SIV Env peptides while expressing little IFN-γ. Such NK cell differentiation was lacking in SIVmac-infected macaques. Adaptive NK cells displayed no increased NKG2C expression. This study reveals a previously unknown profile of NK cell adaptation to a viral infection, thus accelerating strategies toward NK-cell directed therapies and viral control in tissues.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2041-1723eISSN: 2041-1723DOI: 10.1038/s41467-021-21402-1Titel-ID: cdi_doaj_primary_oai_doaj_org_article_7c09c41f3ce44f41931d8a99a69c119f
- Format
- –
- Schlagworte
- Algorithms, Animals, CD4-Positive T-Lymphocytes, CD4-Positive T-Lymphocytes - cytology, CD4-Positive T-Lymphocytes - metabolism, Cell Differentiation, Cell Differentiation - genetics, Cell Differentiation - physiology, Chlorocebus aethiops, Cytotoxicity, Differentiation (biology), Female, Flow Cytometry, Fluorescent Antibody Technique, HIV, Human immunodeficiency virus, Humans, Infections, K562 Cells, Killer Cells, Natural, Killer Cells, Natural - cytology, Killer Cells, Natural - metabolism, Life Sciences, Lymph Nodes, Lymph Nodes - metabolism, Lymphoid Tissue, Lymphoid Tissue - cytology, Lymphoid Tissue - metabolism, Macaca, Major histocompatibility complex, Male, Natural killer cells, NK Cell Lectin-Like Receptor Subfamily C, NK Cell Lectin-Like Receptor Subfamily C - metabolism, NKG2 antigen, Organs, Peptides, Simian Acquired Immunodeficiency Syndrome, Simian Acquired Immunodeficiency Syndrome - immunology, Simian Immunodeficiency Virus, Simian Immunodeficiency Virus - immunology, Simian Immunodeficiency Virus - pathogenicity, Tissues, Toxicity, Transcription, Transcriptome, Transcriptome - genetics, Viral infections, γ-Interferon