Details

Autor(en) / Beteiligte

• Di Rienzi, Sara C
• Jacobson, Juliet
• Kennedy, Elizabeth A
• Bell, Mary E
• Shi, Qiaojuan
• Waters, Jillian L
• Lawrence, Peter
• Brenna, J Thomas
• Britton, Robert A
• Walter, Jens
• Ley, Ruth E

Titel

Resilience of small intestinal beneficial bacteria to the toxicity of soybean oil fatty acids

Ist Teil von

• eLife, 2018-03, Vol.7

Ort / Verlag

England: eLife Sciences Publications Ltd

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Over the past century, soybean oil (SBO) consumption in the United States increased dramatically. The main SBO fatty acid, linoleic acid (18:2), inhibits in vitro the growth of lactobacilli, beneficial members of the small intestinal microbiota. Human-associated lactobacilli have declined in prevalence in Western microbiomes, but how dietary changes may have impacted their ecology is unclear. Here, we compared the in vitro and in vivo effects of 18:2 on and . Directed evolution in vitro in both species led to strong 18:2 resistance with mutations in genes for lipid biosynthesis, acid stress, and the cell membrane or wall. Small-intestinal populations in mice were unaffected by chronic and acute 18:2 exposure, yet harbored both 18:2- sensitive and resistant strains. This work shows that extant small intestinal lactobacilli are protected from toxic dietary components via the gut environment as well as their own capacity to evolve resistance.