Lipids in health and disease, 2017-05, Vol.16 (1), p.84-84, Article 84
2017
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- Autor(en) / Beteiligte
- Titel
- Mangiferin: a natural miracle bioactive compound against lifestyle related disorders
- Ist Teil von
- Lipids in health and disease, 2017-05, Vol.16 (1), p.84-84, Article 84
- Ort / Verlag
- England: BioMed Central
- Erscheinungsjahr
- 2017
- Quelle
- SpringerLink
- Beschreibungen/Notizen
- The current review article is an attempt to explain the therapeutic potential of mangiferin, a bioactive compound of the mango, against lifestyle-related disorders. Mangiferin (2-β-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one) can be isolated from higher plants as well as the mango fruit and their byproducts (i.e. peel, seed, and kernel). It possesses several health endorsing properties such as antioxidant, antimicrobial, antidiabetic, antiallergic, anticancer, hypocholesterolemic, and immunomodulatory. It suppresses the activation of peroxisome proliferator activated receptor isoforms by changing the transcription process. Mangiferin protects against different human cancers, including lung, colon, breast, and neuronal cancers, through the suppression of tumor necrosis factor α expression, inducible nitric oxide synthase potential, and proliferation and induction of apoptosis. It also protects against neural and breast cancers by suppressing the expression of matrix metalloproteinase (MMP)-9 and MMP-7 and inhibiting enzymatic activity, metastatic potential, and activation of the β-catenin pathway. It has the capacity to block lipid peroxidation, in order to provide a shielding effect against physiological threats. Additionally, mangiferin enhances the capacity of the monocyte-macrophage system and possesses antibacterial activity against gram-positive and gram-negative bacteria. This review summarizes the literature pertaining to mangiferin and its associated health claims.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1476-511XeISSN: 1476-511XDOI: 10.1186/s12944-017-0449-yTitel-ID: cdi_doaj_primary_oai_doaj_org_article_0afe28d732294f86811fa6827387964c
- Format
- –
- Schlagworte
- Anti-Inflammatory Agents - chemistry, Anti-Inflammatory Agents - isolation & purification, Anti-Inflammatory Agents - therapeutic use, Antibacterial activity, Antidiabetics, Antineoplastic Agents, Phytogenic - chemistry, Antineoplastic Agents, Phytogenic - isolation & purification, Antineoplastic Agents, Phytogenic - therapeutic use, Antioxidants, Antioxidants - chemistry, Antioxidants - isolation & purification, Antioxidants - therapeutic use, Apoptosis, Bioactive compounds, Bioactive molecules, Breast cancer, Cancer, Cardiovascular Diseases - drug therapy, Cardiovascular Diseases - pathology, Cell cycle, Cognitive Dysfunction - drug therapy, Cognitive Dysfunction - pathology, Colon, Dehydrogenases, Diabetes mellitus, Diabetes Mellitus, Type 2 - drug therapy, Diabetes Mellitus, Type 2 - pathology, Enzymatic activity, Enzymes, Flavonoids, Free radicals, Glucose, Gram-negative bacteria, Health claims, Human cancers, Humans, Hyperlipidemias - drug therapy, Hyperlipidemias - pathology, Hypoglycemic Agents - chemistry, Hypoglycemic Agents - isolation & purification, Hypoglycemic Agents - therapeutic use, Immunomodulation, Iron, Isoforms, Kinases, Lipid peroxidation, Lipids, Macrophages, Mangifera - chemistry, Mangiferin, Matrilysin, Matrix metalloproteinase, Metabolism, Metalloproteinase, Metastases, Mitochondria, Monocytes, Neoplasms - drug therapy, Neoplasms - pathology, Neuralgia - drug therapy, Neuralgia - pathology, Nitric oxide, Nitric-oxide synthase, Nootropic Agents - chemistry, Nootropic Agents - isolation & purification, Nootropic Agents - therapeutic use, Nutrition, Oxidative Stress - drug effects, Review, Rodents, Toxicity, Transcription, Tumor necrosis factor-α, Xanthones - chemistry, Xanthones - isolation & purification, Xanthones - therapeutic use, β-Catenin