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Gallic acid-
grafted-chitosans (GA-
g-chitosans) with four different grafting ratios were prepared by a free radical-induced grafting reaction in order to improve antioxidant and water-solubility. To verify the synthesis of GA-
g-chitosans,
1H NMR and thin layer chromatography were employed, and the results revealed that GA was grafted onto the chitosan. The antioxidant properties of the GA-
g-chitosans were evaluated using several
in vitro models. GA-
g-chitosan (I), which has the highest GA content, showed 92.26% scavenging activity against 2,2-diphenyl-1-picrylhydrazyl and 93.15% hydrogen peroxide scavenging activity at 50
μg/mL. GA-
g-chitosan (I) was also showed higher reducing power compared to others. All GA-
g-chitosans showed improved antioxidant capacities compared to plain chitosan treated in the same conditions without gallic acid grafting. Furthermore, the GA-
g-chitosans also exhibited good cytocompatibility and effectively inhibited the formation of intracellular reactive oxygen species (ROS) in time- and dose-dependent manner in RAW264.7 macrophages.