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Unveiling the biopathway for the design of novel COMT inhibitors

Drug discovery today, 2022-10, Vol.27 (10), p.103328-103328, Article 103328

2022

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Optimization of 8‑Hydroxyquinolines as Inhibitors of Catechol O‑Methyltransferase

Journal of medicinal chemistry, 2018-11, Vol.61 (21), p.9647-9665

2018

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Catechol-O-Methyltransferase Inhibitors in Parkinson’s Disease

Drugs (New York, N.Y.), 2015-02, Vol.75 (2), p.157-174

Mueller, Thomas

2015

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Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy

Clinical epigenetics, 2016-05, Vol.8 (57), p.57-57, Article 57

2016

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Effect of opicapone multiple‐dose regimens on levodopa pharmacokinetics

British journal of clinical pharmacology, 2017-03, Vol.83 (3), p.540-553

2017

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Central nervous system activities of extract Mangifera indica L

Journal of ethnopharmacology, 2020-10, Vol.260, p.112996, Article 112996

2020

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Evaluation of nitrocatechol chalcone and pyrazoline derivatives as inhibitors of catechol-O-methyltransferase and monoamine oxidase

Bioorganic & medicinal chemistry letters, 2020-06, Vol.30 (12), p.127188-127188, Article 127188

2020

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Opicapone: A Review in Parkinson’s Disease

Drugs (New York, N.Y.), 2016-09, Vol.76 (13), p.1293-1300

Scott, Lesley J.

2016

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Integrated Mass Spectrometry Reveals Celastrol As a Novel Catechol-O-methyltransferase Inhibitor

ACS chemical biology, 2022-08, Vol.17 (8), p.2003-2009

2022

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Pharmacoepigenomic Interventions as Novel Potential Treatments for Alzheimer's and Parkinson's Diseases

International journal of molecular sciences, 2018-10, Vol.19 (10), p.3199

2018

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Potent antitumor activity of Laccaic acid and Phenethyl isothiocyanate combination in colorectal cancer via dual inhibition of DNA methyltransferase-1 and Histone deacetylase-1

Toxicology and applied pharmacology, 2019-08, Vol.377, p.114631, Article 114631

2019

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Histone methyltransferase inhibitors induce HIV-1 recovery in resting CD4+ T cells from HIV-1-infected HAART-treated patients

AIDS (London), 2012-07, Vol.26 (12), p.1473-1482

2012

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Pharmacokinetics and pharmacodynamics of levodopa/carbidopa cotherapies for Parkinson's disease

Expert opinion on drug metabolism & toxicology, 2020-05, Vol.16 (5), p.403-414

Müller, Thomas

2020

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Opicapone as an adjunct to levodopa in patients with Parkinson's disease and end-of-dose motor fluctuations: a randomised, double-blind, controlled trial

Lancet neurology, 2016-02, Vol.15 (2), p.154-165

2016

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Inhibition of catechol-O-methyltransferase (COMT) by heparin oligosaccharides with specific structures

Carbohydrate polymers, 2024-05, Vol.332, p.121909-121909, Article 121909

2024

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Liver says no: the ongoing search for safe catechol O-methyltransferase inhibitors to replace tolcapone

Drug discovery today, 2020-10, Vol.25 (10), p.1846-1854

2020

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Pharmacokinetics of opicapone, a third-generation COMT inhibitor, after single and multiple oral administration: A comparative study in the rat

Toxicology and applied pharmacology, 2017-05, Vol.323, p.9-15

2017

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A single- and multiple-dose study to investigate the pharmacokinetics and pharmacodynamics of opicapone, a novel COMT inhibitor, in rat

Neuropharmacology, 2017-10, Vol.125, p.146-155

2017

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Crystal Structure of Catechol O-Methyltransferase Complexed with Nitecapone

Chemical and Pharmaceutical Bulletin, 2020/05/01, Vol.68(5), pp.447-451

2020

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Safety and efficacy of tolcapone in Parkinson’s disease: systematic review

European journal of clinical pharmacology, 2021-06, Vol.77 (6), p.817-829

2021

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Design of Potent and Druglike Nonphenolic Inhibitors for Catechol O‑Methyltransferase Derived from a Fragment Screening Approach Targeting the S‑Adenosyl‑l‑methionine Pocket

Journal of medicinal chemistry, 2016-11, Vol.59 (22), p.10163-10175

2016

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Medicinal Chemistry of Catechol O‑Methyltransferase (COMT) Inhibitors and Their Therapeutic Utility

Journal of medicinal chemistry, 2014-11, Vol.57 (21), p.8692-8717

2014

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Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity

Nature communications, 2016-02, Vol.7 (1), p.10787-10787, Article 10787

2016

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Development of Blood–Brain Barrier Permeable Nitrocatechol-Based Catechol O‑Methyltransferase Inhibitors with Reduced Potential for Hepatotoxicity

Journal of medicinal chemistry, 2016-08, Vol.59 (16), p.7584-7597

2016

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Epigenetic Regulation of Host Defense Peptide Synthesis: Synergy Between Histone Deacetylase Inhibitors and DNA/Histone Methyltransferase Inhibitors

Frontiers in immunology, 2022-04, Vol.13, p.874706-874706

2022

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Unveiling the biopathway for the design of novel COMT inhibitors

Optimization of 8‑Hydroxyquinolines as Inhibitors of Catechol O‑Methyltransferase

Catechol-O-Methyltransferase Inhibitors in Parkinson’s Disease

Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy

Effect of opicapone multiple‐dose regimens on levodopa pharmacokinetics

Central nervous system activities of extract Mangifera indica L

Evaluation of nitrocatechol chalcone and pyrazoline derivatives as inhibitors of catechol-O-methyltransferase and monoamine oxidase

Opicapone: A Review in Parkinson’s Disease

Integrated Mass Spectrometry Reveals Celastrol As a Novel Catechol-O-methyltransferase Inhibitor

Pharmacoepigenomic Interventions as Novel Potential Treatments for Alzheimer's and Parkinson's Diseases

Potent antitumor activity of Laccaic acid and Phenethyl isothiocyanate combination in colorectal cancer via dual inhibition of DNA methyltransferase-1 and Histone deacetylase-1

Histone methyltransferase inhibitors induce HIV-1 recovery in resting CD4+ T cells from HIV-1-infected HAART-treated patients

Pharmacokinetics and pharmacodynamics of levodopa/carbidopa cotherapies for Parkinson's disease

Opicapone as an adjunct to levodopa in patients with Parkinson's disease and end-of-dose motor fluctuations: a randomised, double-blind, controlled trial

Inhibition of catechol-O-methyltransferase (COMT) by heparin oligosaccharides with specific structures

Liver says no: the ongoing search for safe catechol O-methyltransferase inhibitors to replace tolcapone

Pharmacokinetics of opicapone, a third-generation COMT inhibitor, after single and multiple oral administration: A comparative study in the rat

A single- and multiple-dose study to investigate the pharmacokinetics and pharmacodynamics of opicapone, a novel COMT inhibitor, in rat

Crystal Structure of Catechol O-Methyltransferase Complexed with Nitecapone

Safety and efficacy of tolcapone in Parkinson’s disease: systematic review

Design of Potent and Druglike Nonphenolic Inhibitors for Catechol O‑Methyltransferase Derived from a Fragment Screening Approach Targeting the S‑Adenosyl‑l‑methionine Pocket

Medicinal Chemistry of Catechol O‑Methyltransferase (COMT) Inhibitors and Their Therapeutic Utility

Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity

Development of Blood–Brain Barrier Permeable Nitrocatechol-Based Catechol O‑Methyltransferase Inhibitors with Reduced Potential for Hepatotoxicity

Epigenetic Regulation of Host Defense Peptide Synthesis: Synergy Between Histone Deacetylase Inhibitors and DNA/Histone Methyltransferase Inhibitors

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