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Hypomethylating agents (HMA) for the treatment of acute myeloid leukemia and myelodysplastic syndromes: mechanisms of resistance and novel HMA-based therapies

Leukemia, 2021-07, Vol.35 (7), p.1873-1889

2021

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Acute myeloid leukemia: Epidemiology and etiology

Cancer, 2006-11, Vol.107 (9), p.2099-2107

2006

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Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy

Clinical epigenetics, 2016-05, Vol.8 (57), p.57-57, Article 57

2016

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AML1/ETO and its function as a regulator of gene transcription via epigenetic mechanisms

Oncogene, 2021-09, Vol.40 (38), p.5665-5676

2021

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CXCR4 is a prognostic marker in acute myelogenous leukemia

Blood, 2007-01, Vol.109 (2), p.786-791

2007

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Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy

Clinical epigenetics, 2010-12, Vol.1 (3-4), p.117-136

2010

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Clinical development of demethylating agents in hematology

The Journal of clinical investigation, 2014-01, Vol.124 (1), p.40-46

2014

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Incidence and Prognostic Influence of DNMT3A Mutations in Acute Myeloid Leukemia

Journal of clinical oncology, 2011-07, Vol.29 (21), p.2889-2896

2011

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Epigenetic targets in hematopoietic malignancies

Oncogene, 2003-09, Vol.22 (42), p.6489-6496

2003

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Absence of early platelet increment in healthy mice during decitabine treatment

Scientific reports, 2022-12, Vol.12 (1), p.22266-7, Article 22266

2022

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The epigenetics of breast cancer - Opportunities for diagnostics, risk stratification and therapy

Epigenetics, 2022-06, Vol.17 (6), p.612-624

2022

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DNMT and HDAC inhibition induces immunogenic neoantigens from human endogenous retroviral element-derived transcripts

Nature communications, 2023-10, Vol.14 (1), p.6731-19, Article 6731

2023

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Epigenetics in Pancreatic Ductal Adenocarcinoma: Impact on Biology and Utilization in Diagnostics and Treatment

Cancers, 2022-11, Vol.14 (23), p.5926

2022

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The Clinical Value of Decitabine Monotherapy in Patients with Acute Myeloid Leukemia

Advances in therapy, 2022-04, Vol.39 (4), p.1474-1488

2022

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Histone Deacetylase Inhibitors Induce a Very Broad, Pleiotropic Anticancer Drug Resistance Phenotype in Acute Myeloid Leukemia Cells by Modulation of Multiple ABC Transporter Genes

Clinical cancer research, 2009-06, Vol.15 (11), p.3705-3715

2009

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Coalesced Multicentric Analysis of 2,351 Patients With Myelodysplastic Syndromes Indicates an Underestimation of Poor-Risk Cytogenetics of Myelodysplastic Syndromes in the International Prognostic Scoring System

Journal of clinical oncology, 2011-05, Vol.29 (15), p.1963-1970

2011

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Impact of IDH1 R132 Mutations and an IDH1 Single Nucleotide Polymorphism in Cytogenetically Normal Acute Myeloid Leukemia: SNP rs11554137 Is an Adverse Prognostic Factor

Journal of clinical oncology, 2010-05, Vol.28 (14), p.2356-2364

2010

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Parameters detected by geriatric and quality of life assessment in 195 older patients with myelodysplastic syndromes and acute myeloid leukemia are highly predictive for outcome

Haematologica (Roma), 2013-02, Vol.98 (2), p.208-216

2013

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Prognostic impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia

Blood, 2010-07, Vol.116 (4), p.614-616

2010

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A multicenter phase II trial of decitabine as first-line treatment for older patients with acute myeloid leukemia judged unfit for induction chemotherapy

Haematologica (Roma), 2012-03, Vol.97 (3), p.393-401

2012

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High EVI1 Expression Predicts Outcome in Younger Adult Patients With Acute Myeloid Leukemia and Is Associated With Distinct Cytogenetic Abnormalities

Journal of clinical oncology, 2010-04, Vol.28 (12), p.2101-2107

2010

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Structure-activity studies on N-Substituted tranylcypromine derivatives lead to selective inhibitors of lysine specific demethylase 1 (LSD1) and potent inducers of leukemic cell differentiation

European journal of medicinal chemistry, 2018-01, Vol.144, p.52-67

2018

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Hypomethylating agents (HMA) for the treatment of acute myeloid leukemia and myelodysplastic syndromes: mechanisms of resistance and novel HMA-based therapies

Acute myeloid leukemia: Epidemiology and etiology

Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy

AML1/ETO and its function as a regulator of gene transcription via epigenetic mechanisms

CXCR4 is a prognostic marker in acute myelogenous leukemia

DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats

Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy

Clinical development of demethylating agents in hematology

Incidence and Prognostic Influence of DNMT3A Mutations in Acute Myeloid Leukemia

New Comprehensive Cytogenetic Scoring System for Primary Myelodysplastic Syndromes (MDS) and Oligoblastic Acute Myeloid Leukemia After MDS Derived From an International Database Merge

Epigenetic targets in hematopoietic malignancies

Absence of early platelet increment in healthy mice during decitabine treatment

The epigenetics of breast cancer - Opportunities for diagnostics, risk stratification and therapy

DNMT and HDAC inhibition induces immunogenic neoantigens from human endogenous retroviral element-derived transcripts

Epigenetics in Pancreatic Ductal Adenocarcinoma: Impact on Biology and Utilization in Diagnostics and Treatment

The Clinical Value of Decitabine Monotherapy in Patients with Acute Myeloid Leukemia

Histone Deacetylase Inhibitors Induce a Very Broad, Pleiotropic Anticancer Drug Resistance Phenotype in Acute Myeloid Leukemia Cells by Modulation of Multiple ABC Transporter Genes

Coalesced Multicentric Analysis of 2,351 Patients With Myelodysplastic Syndromes Indicates an Underestimation of Poor-Risk Cytogenetics of Myelodysplastic Syndromes in the International Prognostic Scoring System

Impact of IDH1 R132 Mutations and an IDH1 Single Nucleotide Polymorphism in Cytogenetically Normal Acute Myeloid Leukemia: SNP rs11554137 Is an Adverse Prognostic Factor

Parameters detected by geriatric and quality of life assessment in 195 older patients with myelodysplastic syndromes and acute myeloid leukemia are highly predictive for outcome

Prognostic impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia

A multicenter phase II trial of decitabine as first-line treatment for older patients with acute myeloid leukemia judged unfit for induction chemotherapy

High EVI1 Expression Predicts Outcome in Younger Adult Patients With Acute Myeloid Leukemia and Is Associated With Distinct Cytogenetic Abnormalities

Structure-activity studies on N-Substituted tranylcypromine derivatives lead to selective inhibitors of lysine specific demethylase 1 (LSD1) and potent inducers of leukemic cell differentiation

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