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Chemistry, pharmacokinetics, pharmacology and recent novel drug delivery systems of paeonol

Life sciences (1973), 2020-06, Vol.250, p.117544-18, Article 117544

2020

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Paeonol and danshensu combination attenuates apoptosis in myocardial infarcted rats by inhibiting oxidative stress: Roles of Nrf2/HO-1 and PI3K/Akt pathway

Scientific reports, 2016-03, Vol.6 (1), p.23693-23693, Article 23693

2016

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Parental olfactory experience influences behavior and neural structure in subsequent generations

Nature neuroscience, 2014-01, Vol.17 (1), p.89-96

2014

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Non-invasive intranasal administration route directly to the brain using dendrimer nanoplatforms: An opportunity to develop new CNS drugs

European journal of medicinal chemistry, 2021-01, Vol.209, p.112905-112905, Article 112905

2021

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Evaluation of paeonol-loaded transethosomes as transdermal delivery carriers

European journal of pharmaceutical sciences, 2017-03, Vol.99, p.240-245

2017

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Novel chitosan-based solid-lipid nanoparticles to enhance the bio-residence of the miraculous phytochemical “Apocynin”

European journal of pharmaceutical sciences, 2018-11, Vol.124, p.304-318

2018

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Combined NADPH and the NOX inhibitor apocynin provides greater anti-inflammatory and neuroprotective effects in a mouse model of stroke

Free radical biology & medicine, 2017-03, Vol.104, p.333-345

2017

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An antioxidant and anti-ER stress combination therapy elevates phosphorylation of α-Syn at serine 129 and alleviates post-TBI PD-like pathology in a sex-specific manner in mice

Experimental neurology, 2024-07, Vol.377, p.114795-114795, Article 114795

2024

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Neuroprotective role of apocynin against pentylenetetrazole kindling epilepsy and associated comorbidities in mice by suppression of ROS/RNS

Behavioural brain research, 2022-02, Vol.419, p.113699-113699, Article 113699

2022

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Investigation on the antitumor effects of paeonol against renal cell carcinoma based on network pharmacology and experimental validation

Journal of ethnopharmacology, 2022-03, Vol.285, p.114857-114857, Article 114857

2022

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Neuronal protection against oxidative insult by polyanhydride nanoparticle-based mitochondria-targeted antioxidant therapy

Nanomedicine, 2017-04, Vol.13 (3), p.809-820

2017

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Sex, Oxidative Stress, and Hypertension: Insights From Animal Models

Physiology (Bethesda, Md.), 2019-05, Vol.34 (3), p.178-188

2019

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NADPH oxidase mediates depressive behavior induced by chronic stress in mice

The Journal of neuroscience, 2012-07, Vol.32 (28), p.9690-9699

2012

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Attenuating Oxidative Stress by Paeonol Protected against Acetaminophen-Induced Hepatotoxicity in Mice

PloS one, 2016-05, Vol.11 (5), p.e0154375

2016

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Primary Studies on Construction and Evaluation of Ion-Sensitive in situ Gel Loaded with Paeonol-Solid Lipid Nanoparticles for Intranasal Drug Delivery

International journal of nanomedicine, 2020-01, Vol.15, p.3137-3160

2020

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Apocynin as an antidepressant agent: in vivo behavior and oxidative parameters modulation

Behavioural brain research, 2020-06, Vol.388, p.112643-112643, Article 112643

2020

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Hyperglycemia promotes tissue plasminogen activator-induced hemorrhage by Increasing superoxide production

Annals of neurology, 2011-10, Vol.70 (4), p.583-590

2011

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NADPH oxidase 2-derived reactive oxygen species in the hippocampus might contribute to microglial activation in postoperative cognitive dysfunction in aged mice

Brain, behavior, and immunity, 2016-01, Vol.51, p.109-118

2016

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Apocynin and ebselen reduce influenza A virus-induced lung inflammation in cigarette smoke-exposed mice

Scientific reports, 2016-02, Vol.6 (1), p.20983, Article 20983

2016

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Pharmacokinetics and Metabolism of Liposome-Encapsulated 2,4,6-Trihydroxygeranylacetophenone in Rats Using High-Resolution Orbitrap Liquid Chromatography Mass Spectrometry

Molecules (Basel, Switzerland), 2020-07, Vol.25 (13), p.3069

2020

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Enhanced neurogenesis is involved in neuroprotection provided by rottlerin against trimethyltin-induced delayed apoptotic neuronal damage

Life sciences (1973), 2020-12, Vol.262, p.118494-13, Article 118494

2020

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Integrated identification, qualification and quantification strategy for pharmacokinetic profile study of Guizhi Fuling capsule in healthy volunteers

Scientific reports, 2016-08, Vol.6 (1), p.31364, Article 31364

2016

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Pharmacological inhibition of NADPH oxidase protects against cisplatin induced nephrotoxicity in mice by two step mechanism

Food and chemical toxicology, 2015-09, Vol.83, p.251-260

2015

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Apocynin attenuates renal fibrosis via inhibition of NOXs-ROS-ERK-myofibroblast accumulation in UUO rats

Free radical research, 2016-08, Vol.50 (8), p.840-852

2016

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Effect of paeonol on antioxidant and immune regulatory activity in hepatocellular carcinoma rats

Molecules (Basel, Switzerland), 2012-04, Vol.17 (4), p.4672-4683

2012

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Chemistry, pharmacokinetics, pharmacology and recent novel drug delivery systems of paeonol

Paeonol and danshensu combination attenuates apoptosis in myocardial infarcted rats by inhibiting oxidative stress: Roles of Nrf2/HO-1 and PI3K/Akt pathway

Parental olfactory experience influences behavior and neural structure in subsequent generations

Non-invasive intranasal administration route directly to the brain using dendrimer nanoplatforms: An opportunity to develop new CNS drugs

Evaluation of paeonol-loaded transethosomes as transdermal delivery carriers

Novel chitosan-based solid-lipid nanoparticles to enhance the bio-residence of the miraculous phytochemical “Apocynin”

Combined NADPH and the NOX inhibitor apocynin provides greater anti-inflammatory and neuroprotective effects in a mouse model of stroke

An antioxidant and anti-ER stress combination therapy elevates phosphorylation of α-Syn at serine 129 and alleviates post-TBI PD-like pathology in a sex-specific manner in mice

Neuroprotective role of apocynin against pentylenetetrazole kindling epilepsy and associated comorbidities in mice by suppression of ROS/RNS

Investigation on the antitumor effects of paeonol against renal cell carcinoma based on network pharmacology and experimental validation

Neuronal protection against oxidative insult by polyanhydride nanoparticle-based mitochondria-targeted antioxidant therapy

Sex, Oxidative Stress, and Hypertension: Insights From Animal Models

NADPH oxidase mediates depressive behavior induced by chronic stress in mice

Attenuating Oxidative Stress by Paeonol Protected against Acetaminophen-Induced Hepatotoxicity in Mice

Primary Studies on Construction and Evaluation of Ion-Sensitive in situ Gel Loaded with Paeonol-Solid Lipid Nanoparticles for Intranasal Drug Delivery

Apocynin as an antidepressant agent: in vivo behavior and oxidative parameters modulation

Hyperglycemia promotes tissue plasminogen activator-induced hemorrhage by Increasing superoxide production

NADPH oxidase 2-derived reactive oxygen species in the hippocampus might contribute to microglial activation in postoperative cognitive dysfunction in aged mice

Apocynin and ebselen reduce influenza A virus-induced lung inflammation in cigarette smoke-exposed mice

Pharmacokinetics and Metabolism of Liposome-Encapsulated 2,4,6-Trihydroxygeranylacetophenone in Rats Using High-Resolution Orbitrap Liquid Chromatography Mass Spectrometry

Enhanced neurogenesis is involved in neuroprotection provided by rottlerin against trimethyltin-induced delayed apoptotic neuronal damage

Integrated identification, qualification and quantification strategy for pharmacokinetic profile study of Guizhi Fuling capsule in healthy volunteers

Pharmacological inhibition of NADPH oxidase protects against cisplatin induced nephrotoxicity in mice by two step mechanism

Apocynin attenuates renal fibrosis via inhibition of NOXs-ROS-ERK-myofibroblast accumulation in UUO rats

Effect of paeonol on antioxidant and immune regulatory activity in hepatocellular carcinoma rats

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