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Identification of biomarkers to diagnose diseases and find adverse drug reactions by metabolomics

Drug metabolism and pharmacokinetics, 2021-04, Vol.37, p.100373-100373, Article 100373

2021

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jMorp updates in 2020: large enhancement of multi-omics data resources on the general Japanese population

Nucleic acids research, 2021-01, Vol.49 (D1), p.D536

2021

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Determination of novel CYP2D6 haplotype using the targeted sequencing followed by the long-read sequencing and the functional characterization in the Japanese population

Journal of human genetics, 2021-02, Vol.66 (2), p.139-149

2021

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Heterologous expression of high-activity cytochrome P450 in mammalian cells

Scientific reports, 2020-08, Vol.10 (1), p.14193, Article 14193

2020

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Structural investigation of pathogenic variants in dihydropyrimidinase using molecular dynamics simulations

Journal of molecular graphics & modelling, 2022-12, Vol.117, p.108288, Article 108288

2022

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Rare but impaired flavin-containing monooxygenase 3 (FMO3) variants reported in a recently updated Japanese mega-databank of genome resources

Drug metabolism and pharmacokinetics, 2024-04, Vol.55, p.100539-100539, Article 100539

2024

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Nrf2 deficiency deteriorates diabetic kidney disease in Akita model mice

Redox biology, 2022-12, Vol.58, p.102525-102525, Article 102525

2022

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Development of a Simultaneous Liquid Chromatography-Tandem Mass Spectrometry Analytical Method for Urinary Endogenous Substrates and Metabolites for Predicting Cytochrome P450 3A4 Activity

Biological and Pharmaceutical Bulletin, 2023/03/01, Vol.46(3), pp.455-463

2023

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Genetic variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects identified by phenotyping for trimethylaminuria and found in a database of genome resources

Drug metabolism and pharmacokinetics, 2021-06, Vol.38, p.100387, Article 100387

2021

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Functional Characterization of 21 Allelic Variants of Dihydropyrimidine Dehydrogenase Identified in 1070 Japanese Individuals

Drug metabolism and disposition, 2018-08, Vol.46 (8), p.1083-1090

2018

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Functional Characterization of 12 Dihydropyrimidinase Allelic Variants in Japanese Individuals for the Prediction of 5-Fluorouracil Treatment-Related Toxicity

Drug metabolism and disposition, 2023-02, Vol.51 (2), p.165-173

2023

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Further survey of genetic variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects found in an updated database of genome resources and identified by phenotyping for trimethylaminuria

Drug metabolism and pharmacokinetics, 2022-10, Vol.46, p.100465-100465, Article 100465

2022

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Global Proteomics for Identifying the Alteration Pathway of Niemann–Pick Disease Type C Using Hepatic Cell Models

International journal of molecular sciences, 2023-10, Vol.24 (21), p.15642

2023

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CYP2D6 genotyping analysis and functional characterization of novel allelic variants in a Ni-Vanuatu and Kenyan population by assessing dextromethorphan O-demethylation activity

Drug metabolism and pharmacokinetics, 2020-02, Vol.35 (1), p.89-101

2020

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Functional characterization of 21 allelic variants of dihydropyrimidinase

Biochemical pharmacology, 2017-11, Vol.143, p.118-128

2017

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Genetic polymorphisms of dihydropyrimidinase in a Japanese patient with capecitabine-induced toxicity

PloS one, 2015-04, Vol.10 (4), p.e0124818

2015

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Importance of Rare DPYD Genetic Polymorphisms for 5-Fluorouracil Therapy in the Japanese Population

Frontiers in pharmacology, 2022-06, Vol.13, p.930470-930470

2022

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Genetic variants of flavin-containing monooxygenase 3 (FMO3) derived from Japanese subjects with the trimethylaminuria phenotype and whole-genome sequence data from a large Japanese database

Drug metabolism and pharmacokinetics, 2019-10, Vol.34 (5), p.334-339

2019

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Functional characterization of 40 CYP2B6 allelic variants by assessing efavirenz 8-hydroxylation

Biochemical pharmacology, 2018-10, Vol.156, p.420-430

2018

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Development and application of a rapid and sensitive genotyping method for pharmacogene variants using the single-stranded tag hybridization chromatographic printed-array strip (STH-PAS)

Drug metabolism and pharmacokinetics, 2018-12, Vol.33 (6), p.258-263

2018

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Wide-Targeted Metabolome Analysis Identifies Potential Biomarkers for Prognosis Prediction of Epithelial Ovarian Cancer

Toxins, 2021-06, Vol.13 (7), p.461

2021

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In Vitro Assessment of Fluoropyrimidine-Metabolizing Enzymes: Dihydropyrimidine Dehydrogenase, Dihydropyrimidinase, and β-Ureidopropionase

Journal of clinical medicine, 2020-07, Vol.9 (8), p.2342

2020

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Nrf2 plays a critical role in the metabolic response during and after spaceflight

Communications biology, 2021-12, Vol.4 (1), p.1381-1381, Article 1381

2021

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Rapid Genetic Diagnosis for Okinawan Patients with Enlarged Vestibular Aqueduct Using Single-Stranded Tag Hybridization Chromatographic Printed-Array Strip

Journal of clinical medicine, 2022-02, Vol.11 (4), p.1099

2022

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Improvement of a Rapid and Highly Sensitive Method for the Diagnosis of the Mitochondrial m.1555A>G Mutation Based on a Single-Stranded Tag Hybridization Chromatographic Printed-Array Strip

Genetic testing and molecular biomarkers, 2021-01, Vol.25 (1), p.79

2021

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Identification of biomarkers to diagnose diseases and find adverse drug reactions by metabolomics

jMorp updates in 2020: large enhancement of multi-omics data resources on the general Japanese population

Determination of novel CYP2D6 haplotype using the targeted sequencing followed by the long-read sequencing and the functional characterization in the Japanese population

Heterologous expression of high-activity cytochrome P450 in mammalian cells

Structural investigation of pathogenic variants in dihydropyrimidinase using molecular dynamics simulations

Rare but impaired flavin-containing monooxygenase 3 (FMO3) variants reported in a recently updated Japanese mega-databank of genome resources

Nrf2 deficiency deteriorates diabetic kidney disease in Akita model mice

Development of a Simultaneous Liquid Chromatography-Tandem Mass Spectrometry Analytical Method for Urinary Endogenous Substrates and Metabolites for Predicting Cytochrome P450 3A4 Activity

Genetic variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects identified by phenotyping for trimethylaminuria and found in a database of genome resources

Functional Characterization of 21 Allelic Variants of Dihydropyrimidine Dehydrogenase Identified in 1070 Japanese Individuals

Functional Characterization of 12 Dihydropyrimidinase Allelic Variants in Japanese Individuals for the Prediction of 5-Fluorouracil Treatment-Related Toxicity

Further survey of genetic variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects found in an updated database of genome resources and identified by phenotyping for trimethylaminuria

Global Proteomics for Identifying the Alteration Pathway of Niemann–Pick Disease Type C Using Hepatic Cell Models

CYP2D6 genotyping analysis and functional characterization of novel allelic variants in a Ni-Vanuatu and Kenyan population by assessing dextromethorphan O-demethylation activity

Functional characterization of 21 allelic variants of dihydropyrimidinase

Genetic polymorphisms of dihydropyrimidinase in a Japanese patient with capecitabine-induced toxicity

Importance of Rare DPYD Genetic Polymorphisms for 5-Fluorouracil Therapy in the Japanese Population

Genetic variants of flavin-containing monooxygenase 3 (FMO3) derived from Japanese subjects with the trimethylaminuria phenotype and whole-genome sequence data from a large Japanese database

Functional characterization of 40 CYP2B6 allelic variants by assessing efavirenz 8-hydroxylation

Development and application of a rapid and sensitive genotyping method for pharmacogene variants using the single-stranded tag hybridization chromatographic printed-array strip (STH-PAS)

Wide-Targeted Metabolome Analysis Identifies Potential Biomarkers for Prognosis Prediction of Epithelial Ovarian Cancer

In Vitro Assessment of Fluoropyrimidine-Metabolizing Enzymes: Dihydropyrimidine Dehydrogenase, Dihydropyrimidinase, and β-Ureidopropionase

Nrf2 plays a critical role in the metabolic response during and after spaceflight

Rapid Genetic Diagnosis for Okinawan Patients with Enlarged Vestibular Aqueduct Using Single-Stranded Tag Hybridization Chromatographic Printed-Array Strip

Improvement of a Rapid and Highly Sensitive Method for the Diagnosis of the Mitochondrial m.1555A>G Mutation Based on a Single-Stranded Tag Hybridization Chromatographic Printed-Array Strip

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