Trends in cell biology, 2015-07, Vol.25 (7), p.427-436
2015
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- Autor(en) / Beteiligte
- Titel
- From zero to six double bonds: phospholipid unsaturation and organelle function
- Ist Teil von
- Trends in cell biology, 2015-07, Vol.25 (7), p.427-436
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2015
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • Membrane bound organelles differ by the acyl chain profile of their phospholipids. • Monounsaturated phospholipids and curvature cooperate to create lipid-packing defects. • Polyunsaturated phospholipids have no intrinsic shape and correct lipid-packing defects. • Polyunsaturated phospholipids soften fast mechanical stresses (e.g., curvature).
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0962-8924eISSN: 1879-3088DOI: 10.1016/j.tcb.2015.03.004Titel-ID: cdi_pubmed_primary_25906908
- Format
- –
- Schlagworte
- 1-Acylglycerophosphocholine O-Acyltransferase - metabolism, Animals, Biomechanical Phenomena, Dietary Fats - metabolism, Endoplasmic Reticulum - chemistry, Endoplasmic Reticulum - physiology, Endoplasmic Reticulum - ultrastructure, Eukaryotic Cells - chemistry, Eukaryotic Cells - metabolism, Eukaryotic Cells - ultrastructure, Fatty Acids - chemistry, Fatty Acids - metabolism, Fatty Acids, Monounsaturated - chemistry, Fatty Acids, Monounsaturated - metabolism, Fatty Acids, Unsaturated - chemistry, Fatty Acids, Unsaturated - metabolism, Humans, lipid remodeling, lipid-packing defect, mechanotransduction, membrane curvature, Pathology, Phospholipids - chemistry, Phospholipids - metabolism, polyunsaturated phospholipid, Stress, Mechanical, Synaptic Vesicles - chemistry, Synaptic Vesicles - physiology, Synaptic Vesicles - ultrastructure