Details

Autor(en) / Beteiligte

• Tadaka, Shu
• Hishinuma, Eiji
• Komaki, Shohei
• Motoike, Ikuko N
• Kawashima, Junko
• Saigusa, Daisuke
• Inoue, Jin
• Takayama, Jun
• Okamura, Yasunobu
• Aoki, Yuichi
• Shirota, Matsuyuki
• Otsuki, Akihito
• Katsuoka, Fumiki
• Shimizu, Atsushi
• Tamiya, Gen
• Koshiba, Seizo
• Sasaki, Makoto
• Yamamoto, Masayuki
• Kinoshita, Kengo

Titel

jMorp updates in 2020: large enhancement of multi-omics data resources on the general Japanese population

Ist Teil von

• Nucleic acids research, 2021-01, Vol.49 (D1), p.D536

Ort / Verlag

England

Erscheinungsjahr

2021

Link zum Volltext

Beschreibungen/Notizen

• In the Tohoku Medical Megabank project, genome and omics analyses of participants in two cohort studies were performed. A part of the data is available at the Japanese Multi Omics Reference Panel (jMorp; https://jmorp.megabank.tohoku.ac.jp) as a web-based database, as reported in our previous manuscript published in Nucleic Acid Research in 2018. At that time, jMorp mainly consisted of metabolome data; however, now genome, methylome, and transcriptome data have been integrated in addition to the enhancement of the number of samples for the metabolome data. For genomic data, jMorp provides a Japanese reference sequence obtained using de novo assembly of sequences from three Japanese individuals and allele frequencies obtained using whole-genome sequencing of 8,380 Japanese individuals. In addition, the omics data include methylome and transcriptome data from ∼300 samples and distribution of concentrations of more than 755 metabolites obtained using high-throughput nuclear magnetic resonance and high-sensitivity mass spectrometry. In summary, jMorp now provides four different kinds of omics data (genome, methylome, transcriptome, and metabolome), with a user-friendly web interface. This will be a useful scientific data resource on the general population for the discovery of disease biomarkers and personalized disease prevention and early diagnosis.