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The role of TGF-β/SMAD4 signaling in cancer

International journal of biological sciences, 2018-01, Vol.14 (2), p.111-123

2018

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A reinforcing HNF4-SMAD4 feed-forward module stabilizes enterocyte identity

Nature genetics, 2019-05, Vol.51 (5), p.777-785

2019

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Micropeptide CIP2A‐BP encoded by LINC00665 inhibits triple‐negative breast cancer progression

The EMBO journal, 2020-01, Vol.39 (1), p.e102190-n/a

2020

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SMAD4 Gene Mutation Renders Pancreatic Cancer Resistance to Radiotherapy through Promotion of Autophagy

Clinical cancer research, 2018-07, Vol.24 (13), p.3176-3185

2018

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Genistein downregulates onco-miR-1260b and upregulates sFRP1 and Smad4 via demethylation and histone modification in prostate cancer cells

British journal of cancer, 2014-03, Vol.110 (6), p.1645-1654

2014

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Febrile Temperature Critically Controls the Differentiation and Pathogenicity of T Helper 17 Cells

Immunity (Cambridge, Mass.), 2020-02, Vol.52 (2), p.328-341.e5

2020

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Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways

Nature communications, 2021-11, Vol.12 (1), p.6374-6374, Article 6374

2021

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Smad4 Deficiency in Smooth Muscle Cells Initiates the Formation of Aortic Aneurysm

Circulation research, 2016-02, Vol.118 (3), p.388-399

2016

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Curcumin and emodin down-regulate TGF-β signaling pathway in human cervical cancer cells

PloS one, 2015-03, Vol.10 (3), p.e0120045

2015

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MultiNotch MS3 Enables Accurate, Sensitive, and Multiplexed Detection of Differential Expression across Cancer Cell Line Proteomes

Analytical chemistry (Washington), 2014-07, Vol.86 (14), p.7150-7158

2014

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Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

Blood, 2008-08, Vol.112 (4), p.1503-1509

2008

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Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors

Nature communications, 2017-12, Vol.8 (1), p.2070-15, Article 2070

2017

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SMAD4 Prevents Flow Induced Arteriovenous Malformations by Inhibiting Casein Kinase 2

Circulation (New York, N.Y.), 2018-11, Vol.138 (21), p.2379-2394

2018

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SMAD4―dependent barrier constrains prostate cancer growth and metastatic progression

Nature (London), 2011-02, Vol.470 (7333), p.269-273

2011

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O-GlcNAc stabilizes SMAD4 by inhibiting GSK-3β-mediated proteasomal degradation

Scientific reports, 2020-11, Vol.10 (1), p.19908-19908, Article 19908

2020

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PRMT5 methylating SMAD4 activates TGF-β signaling and promotes colorectal cancer metastasis

Oncogene, 2023-05, Vol.42 (19), p.1572-1584

2023

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BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation

Development (Cambridge), 2009-04, Vol.136 (7), p.1093-1104

2009

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Hypomorph mutation-directed small-molecule protein-protein interaction inducers to restore mutant SMAD4-suppressed TGF-β signaling

Cell chemical biology, 2021-05, Vol.28 (5), p.636-647.e5

2021

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SMAD4 impedes the conversion of NK cells into ILC1-like cells by curtailing non-canonical TGF-β signaling

Nature immunology, 2017-09, Vol.18 (9), p.995

2017

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A pan-cancer atlas of somatic mutations in miRNA biogenesis genes

Nucleic acids research, 2021-01, Vol.49 (2), p.601

2021

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Loss of SMAD4 protein expression in gastrointestinal and extra‐gastrointestinal carcinomas

Histopathology, 2019-10, Vol.75 (4), p.546-551

2019

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Lantern-shaped flexible RNA origami for Smad4 mRNA delivery and growth suppression of colorectal cancer

Nature communications, 2023-03, Vol.14 (1), p.1307-1307, Article 1307

2023

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A Reciprocal Role of the Smad4‐Taz Axis in Osteogenesis and Adipogenesis of Mesenchymal Stem Cells

Stem cells (Dayton, Ohio), 2019-03, Vol.37 (3), p.368-381

2019

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BMP signaling controls muscle mass

Nature genetics, 2013-11, Vol.45 (11), p.1309-1318

2013

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The role of TGF-β/SMAD4 signaling in cancer

A reinforcing HNF4-SMAD4 feed-forward module stabilizes enterocyte identity

Micropeptide CIP2A‐BP encoded by LINC00665 inhibits triple‐negative breast cancer progression

SMAD4 Gene Mutation Renders Pancreatic Cancer Resistance to Radiotherapy through Promotion of Autophagy

Genistein downregulates onco-miR-1260b and upregulates sFRP1 and Smad4 via demethylation and histone modification in prostate cancer cells

Febrile Temperature Critically Controls the Differentiation and Pathogenicity of T Helper 17 Cells

Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways

Digital next-generation sequencing identifies low-abundance mutations in pancreatic juice samples collected from the duodenum of patients with pancreatic cancer and intraductal papillary mucinous neoplasms

Smad4 Deficiency in Smooth Muscle Cells Initiates the Formation of Aortic Aneurysm

Curcumin and emodin down-regulate TGF-β signaling pathway in human cervical cancer cells

MultiNotch MS3 Enables Accurate, Sensitive, and Multiplexed Detection of Differential Expression across Cancer Cell Line Proteomes

Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors

SMAD4 Prevents Flow Induced Arteriovenous Malformations by Inhibiting Casein Kinase 2

SMAD4―dependent barrier constrains prostate cancer growth and metastatic progression

O-GlcNAc stabilizes SMAD4 by inhibiting GSK-3β-mediated proteasomal degradation

PRMT5 methylating SMAD4 activates TGF-β signaling and promotes colorectal cancer metastasis

BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation

Hypomorph mutation-directed small-molecule protein-protein interaction inducers to restore mutant SMAD4-suppressed TGF-β signaling

SMAD4 impedes the conversion of NK cells into ILC1-like cells by curtailing non-canonical TGF-β signaling

A pan-cancer atlas of somatic mutations in miRNA biogenesis genes

Loss of SMAD4 protein expression in gastrointestinal and extra‐gastrointestinal carcinomas

Lantern-shaped flexible RNA origami for Smad4 mRNA delivery and growth suppression of colorectal cancer

A Reciprocal Role of the Smad4‐Taz Axis in Osteogenesis and Adipogenesis of Mesenchymal Stem Cells

BMP signaling controls muscle mass

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