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Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

Nature communications, 2015-12, Vol.6 (1), p.10166-10166, Article 10166

2015

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Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus

Nature (London), 2015-06, Vol.522 (7556), p.359-362

2015

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Molecular tuning of farnesoid X receptor partial agonism

Nature communications, 2019-07, Vol.10 (1), p.2915-14, Article 2915

2019

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D3R Grand Challenge 2: blind prediction of protein–ligand poses, affinity rankings, and relative binding free energies

Journal of computer-aided molecular design, 2018-01, Vol.32 (1), p.1-20

2018

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Targeting Nuclear Receptors with PROTAC degraders

Molecular and cellular endocrinology, 2019-08, Vol.493, p.110452-110452, Article 110452

2019

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The Bile Acid Receptor FXR Is a Modulator of Intestinal Innate Immunity

The Journal of immunology (1950), 2009-11, Vol.183 (10), p.6251-6261

2009

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FXR-dependent Rubicon induction impairs autophagy in models of human cholestasis

Journal of hepatology, 2020-06, Vol.72 (6), p.1122-1131

2020

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Performance of HADDOCK and a simple contact-based protein–ligand binding affinity predictor in the D3R Grand Challenge 2

Journal of computer-aided molecular design, 2018-01, Vol.32 (1), p.175-185

2018

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Overview of nomenclature of nuclear receptors

Pharmacological reviews, 2006-12, Vol.58 (4), p.685

2006

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Structure-function analysis of barley NLR immune receptor MLA10 reveals its cell compartment specific activity in cell death and disease resistance

PLoS pathogens, 2012-06, Vol.8 (6), p.e1002752-e1002752

2012

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Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia

Nature medicine, 2007-06, Vol.13 (6), p.730-735

2007

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Dual activation of the bile acid nuclear receptor FXR and G-protein-coupled receptor TGR5 protects mice against atherosclerosis

PloS one, 2014-09, Vol.9 (9), p.e108270-e108270

2014

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Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1

Proceedings of the National Academy of Sciences - PNAS, 2013-01, Vol.110 (4), p.1303-1308

2013

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Structural Basis for Small Molecule NDB (N-Benzyl-N-(3-(tert-butyl)-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino) Benzamide) as a Selective Antagonist of Farnesoid X Receptor α (FXRα) in Stabilizing the Homodimerization of the Receptor

The Journal of biological chemistry, 2015-08, Vol.290 (32), p.19888-19899

2015

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A nuclear―receptor―dependent phosphatidylcholine pathway with antidiabetic effects

Nature (London), 2011-06, Vol.474 (7352), p.506-510

2011

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Arthropod nuclear receptors and their role in molting

The FEBS journal, 2009-11, Vol.276 (21), p.6128-6157

2009

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The nuclear receptor LXR is a glucose sensor

Nature, 2007-01, Vol.445 (7124), p.219-223

2007

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Regulation of Antibacterial Defense in the Small Intestine by the Nuclear Bile Acid Receptor

Proceedings of the National Academy of Sciences - PNAS, 2006-03, Vol.103 (10), p.3920-3925

2006

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Farnesoid X receptor agonist GW4064 ameliorates lipopolysaccharide-induced ileocolitis through TLR4/MyD88 pathway related mitochondrial dysfunction in mice

Biochemical and biophysical research communications, 2017-08, Vol.490 (3), p.841-848

2017

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REV-ERB and ROR nuclear receptors as drug targets

Nature reviews. Drug discovery, 2014-03, Vol.13 (3), p.197-216

2014

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Phenobarbital Meets Phosphorylation of Nuclear Receptors

Drug metabolism and disposition, 2017-05, Vol.45 (5), p.532-539

Negishi, Masahiko

2017

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Incorporating chemical sub-structures and protein evolutionary information for inferring drug-target interactions

Scientific reports, 2020-04, Vol.10 (1), p.6641, Article 6641

2020

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CRM1 Promotes Capsid Disassembly and Nuclear Envelope Translocation of Adenovirus Independently of Its Export Function

Journal of virology, 2022-02, Vol.96 (3), p.e0127321

2022

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Deciphering the nuclear bile acid receptor FXR paradigm

Nuclear receptor signaling, 2010-11, Vol.8 (1), p.e005-e005

2010

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Farnesoid X receptor deficiency in mice leads to increased intestinal epithelial cell proliferation and tumor development

The Journal of pharmacology and experimental therapeutics, 2009-02, Vol.328 (2), p.469

2009

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Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus

Molecular tuning of farnesoid X receptor partial agonism

D3R Grand Challenge 2: blind prediction of protein–ligand poses, affinity rankings, and relative binding free energies

Targeting Nuclear Receptors with PROTAC degraders

The Bile Acid Receptor FXR Is a Modulator of Intestinal Innate Immunity

FXR-dependent Rubicon induction impairs autophagy in models of human cholestasis

Performance of HADDOCK and a simple contact-based protein–ligand binding affinity predictor in the D3R Grand Challenge 2

Overview of nomenclature of nuclear receptors

Structure-function analysis of barley NLR immune receptor MLA10 reveals its cell compartment specific activity in cell death and disease resistance

Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia

Dual activation of the bile acid nuclear receptor FXR and G-protein-coupled receptor TGR5 protects mice against atherosclerosis

Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1

Structural Basis for Small Molecule NDB (N-Benzyl-N-(3-(tert-butyl)-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino) Benzamide) as a Selective Antagonist of Farnesoid X Receptor α (FXRα) in Stabilizing the Homodimerization of the Receptor

A nuclear―receptor―dependent phosphatidylcholine pathway with antidiabetic effects

Arthropod nuclear receptors and their role in molting

The nuclear receptor LXR is a glucose sensor

Regulation of Antibacterial Defense in the Small Intestine by the Nuclear Bile Acid Receptor

Farnesoid X receptor agonist GW4064 ameliorates lipopolysaccharide-induced ileocolitis through TLR4/MyD88 pathway related mitochondrial dysfunction in mice

REV-ERB and ROR nuclear receptors as drug targets

Phenobarbital Meets Phosphorylation of Nuclear Receptors

Incorporating chemical sub-structures and protein evolutionary information for inferring drug-target interactions

CRM1 Promotes Capsid Disassembly and Nuclear Envelope Translocation of Adenovirus Independently of Its Export Function

Deciphering the nuclear bile acid receptor FXR paradigm

Farnesoid X receptor deficiency in mice leads to increased intestinal epithelial cell proliferation and tumor development

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