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Picking the point of inhibition: a comparative review of PI3K/AKT/mTOR pathway inhibitors

Molecular cancer therapeutics, 2014-05, Vol.13 (5), p.1021-1031

2014

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Classes of phosphoinositide 3-kinases at a glance

Journal of cell science, 2014-03, Vol.127 (Pt 5), p.923-928

2014

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PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer

Molecular cancer, 2023-08, Vol.22 (1), p.1-138, Article 138

2023

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Small molecule inhibitors of phosphoinositide 3-kinase (PI3K) delta and gamma

Current topics in medicinal chemistry, 2009-05, Vol.9 (8), p.738

2009

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Abstract 1414 Investigating FOXO4 target genes in GBM

The Journal of biological chemistry, 2024-03, Vol.300 (3)

2024

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PI3K inhibition in breast cancer: Identifying and overcoming different flavors of resistance

Critical reviews in oncology/hematology, 2021-06, Vol.162, p.103334-103334, Article 103334

2021

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PI3Kδ Pathway Dysregulation and Unique Features of Its Inhibition by Leniolisib in Activated PI3Kδ Syndrome and Beyond

The journal of allergy and clinical immunology in practice (Cambridge, MA), 2024-01, Vol.12 (1), p.69-78

2024

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Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis

Molecular cell, 2021-02, Vol.81 (4), p.708-723.e5

2021

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Structural Determinants of Isoform Selectivity in PI3K Inhibitors

Biomolecules (Basel, Switzerland), 2019-02, Vol.9 (3), p.82

2019

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Combating TKI resistance in CML by inhibiting the PI3K/Akt/mTOR pathway in combination with TKIs: a review

Medical oncology (Northwood, London, England), 2021-01, Vol.38 (1), p.10-10, Article 10

2021

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Notch3 as a novel therapeutic target for the treatment of ADPKD by regulating cell proliferation and renal cyst development

Biochemical pharmacology, 2024-06, Vol.224, p.116200-116200, Article 116200

2024

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PI3K/AKT signaling pathway and cancer: an updated review

Annals of medicine (Helsinki), 2014-09, Vol.46 (6), p.372-383

2014

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Somatic Loss-of-Function PIK3R1 and Activating Non-hotspot PIK3CA Mutations Associated with Capillary Malformation with Dilated Veins (CMDV)

Journal of investigative dermatology, 2024-02

2024

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Silencing of COL1A2, COL6A3, and THBS2 inhibits gastric cancer cell proliferation, migration, and invasion while promoting apoptosis through the PI3k‐Akt signaling pathway

Journal of cellular biochemistry, 2018-06, Vol.119 (6), p.4420-4434

2018

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Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy

Journal of lipid research, 2020-05, Vol.61 (5), p.611-635

2020

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PI3K inhibitors as new cancer therapeutics: implications for clinical trial design

OncoTargets and therapy, 2016-01, Vol.9 (Issue 1), p.203-210

2016

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Efficacy of PI3K inhibitors in advanced breast cancer

Annals of oncology, 2019-12, Vol.30 (Suppl_10), p.x12-x20

2019

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Regulatory role of RBM39 in acute myeloid leukemia: Mediation through the PI3K/AKT pathway

Biochimica et biophysica acta. Molecular cell research, 2024-01, Vol.1871 (1), p.119607-119607, Article 119607

2024

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Therapeutic modulation of the phosphatidylinositol 3-kinases (PI3K) pathway in cerebral ischemic injury

Brain research, 2021-06, Vol.1761, p.147399-147399, Article 147399

2021

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Glimepiride ameliorates renal toxicity induced by cadmium in mice: Modulation of Jun N terminal kinase (JNK)/nuclear factor kappa B (NF-κB) and phosphatidylinositol 3-kinases (PI3K)/protein kinase (AKT) pathways

Life sciences (1973), 2022-12, Vol.311, p.121184-121184, Article 121184

2022

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VPS34-IN1 induces apoptosis of ER+ breast cancer cells via activating PERK/ATF4/CHOP pathway

Biochemical pharmacology, 2023-08, Vol.214, p.115634-115634, Article 115634

2023

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Discovery of novel quinazolinone derivatives as high potent and selective PI3Kδ and PI3Kδ/γ inhibitors

European journal of medicinal chemistry, 2018-05, Vol.151, p.9-17

2018

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115 Off-label treatment with the selective PI3Kδ inhibitor leniolisib in 2 pediatric patients with activated phosphoinositide 3-kinase delta syndrome 2 (APDS2)

Clinical immunology (Orlando, Fla.), 2024-05, Vol.262

2024

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198 Activated PI3Kδ Syndrome (APDS) associated with G6PD deficiency and reaction to BCG

Clinical immunology (Orlando, Fla.), 2024-05, Vol.262

2024

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PI3K Inhibitors in Breast Cancer Therapy

Current oncology reports, 2019-12, Vol.21 (12), p.110-9, Article 110

2019

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Picking the point of inhibition: a comparative review of PI3K/AKT/mTOR pathway inhibitors

Classes of phosphoinositide 3-kinases at a glance

PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer

Small molecule inhibitors of phosphoinositide 3-kinase (PI3K) delta and gamma

Abstract 1414 Investigating FOXO4 target genes in GBM

PI3K inhibition in breast cancer: Identifying and overcoming different flavors of resistance

PI3Kδ Pathway Dysregulation and Unique Features of Its Inhibition by Leniolisib in Activated PI3Kδ Syndrome and Beyond

Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis

Structural Determinants of Isoform Selectivity in PI3K Inhibitors

Combating TKI resistance in CML by inhibiting the PI3K/Akt/mTOR pathway in combination with TKIs: a review

Notch3 as a novel therapeutic target for the treatment of ADPKD by regulating cell proliferation and renal cyst development

PI3K/AKT signaling pathway and cancer: an updated review

Somatic Loss-of-Function PIK3R1 and Activating Non-hotspot PIK3CA Mutations Associated with Capillary Malformation with Dilated Veins (CMDV)

Silencing of COL1A2, COL6A3, and THBS2 inhibits gastric cancer cell proliferation, migration, and invasion while promoting apoptosis through the PI3k‐Akt signaling pathway

Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy

PI3K inhibitors as new cancer therapeutics: implications for clinical trial design

Efficacy of PI3K inhibitors in advanced breast cancer

Regulatory role of RBM39 in acute myeloid leukemia: Mediation through the PI3K/AKT pathway

Therapeutic modulation of the phosphatidylinositol 3-kinases (PI3K) pathway in cerebral ischemic injury

Glimepiride ameliorates renal toxicity induced by cadmium in mice: Modulation of Jun N terminal kinase (JNK)/nuclear factor kappa B (NF-κB) and phosphatidylinositol 3-kinases (PI3K)/protein kinase (AKT) pathways

VPS34-IN1 induces apoptosis of ER+ breast cancer cells via activating PERK/ATF4/CHOP pathway

Discovery of novel quinazolinone derivatives as high potent and selective PI3Kδ and PI3Kδ/γ inhibitors

115 Off-label treatment with the selective PI3Kδ inhibitor leniolisib in 2 pediatric patients with activated phosphoinositide 3-kinase delta syndrome 2 (APDS2)

198 Activated PI3Kδ Syndrome (APDS) associated with G6PD deficiency and reaction to BCG

PI3K Inhibitors in Breast Cancer Therapy

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