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Probing the Role of the Covalent Linkage of Ferrocene into a Chloroquine Template

Journal of medicinal chemistry, 2006-07, Vol.49 (15), p.4707-4714

2006

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Nonclassical Phenyl Bioisosteres as Effective Replacements in a Series of Novel Open-Source Antimalarials

Journal of medicinal chemistry, 2020-10, Vol.63 (20), p.11585-11601

2020

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Has Ferrocene Really Delivered Its Role in Accentuating the Bioactivity of Organic Scaffolds?

Journal of medicinal chemistry, 2021-12, Vol.64 (23), p.16865-16921

2021

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Artemisinin-Derived Dimers: Potent Antimalarial and Anticancer Agents

Journal of medicinal chemistry, 2016-08, Vol.59 (16), p.7360-7388

2016

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Accepting the Invitation to Open Innovation in Malaria Drug Discovery: Synthesis, Biological Evaluation, and Investigation on the Structure–Activity Relationships of Benzo[b]thiophene-2-carboxamides as Antimalarial Agents

Journal of medicinal chemistry, 2017-03, Vol.60 (5), p.1959-1970

2017

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Quinoline Drug–Heme Interactions and Implications for Antimalarial Cytostatic versus Cytocidal Activities

Journal of medicinal chemistry, 2013-07, Vol.56 (13), p.5231-5246

2013

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Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action

Journal of medicinal chemistry, 2016-06, Vol.59 (12), p.5587-5603

2016

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Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate

Journal of medicinal chemistry, 2017-07, Vol.60 (13), p.5889-5908

2017

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Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite

Journal of medicinal chemistry, 2018-07, Vol.61 (13), p.5664-5678

2018

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Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria

Journal of medicinal chemistry, 2018-07, Vol.61 (13), p.5692-5703

2018

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Quinoline–Pyrimidine Hybrids: Synthesis, Antiplasmodial Activity, SAR, and Mode of Action Studies

Journal of medicinal chemistry, 2014-01, Vol.57 (2), p.435-448

2014

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Aminoalkoxycarbonyloxymethyl Ether Prodrugs with a pH-Triggered Release Mechanism: A Case Study Improving the Solubility, Bioavailability, and Efficacy of Antimalarial 4(1H)‑Quinolones with Single Dose Cures

Journal of medicinal chemistry, 2021-05, Vol.64 (10), p.6581-6595

2021

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Synthesis and Structure–Activity Relationship of Dual-Stage Antimalarial Pyrazolo[3,4‑b]pyridines

Journal of medicinal chemistry, 2020-10, Vol.63 (20), p.11902-11919

2020

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Subtilisin-like Serine Protease 1 (SUB1) as an Emerging Antimalarial Drug Target: Current Achievements in Inhibitor Discovery

Journal of medicinal chemistry, 2022-10, Vol.65 (19), p.12535-12545

2022

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Discovery, Synthesis, and Optimization of Antimalarial 4(1H)‑Quinolone-3-Diarylethers

Journal of medicinal chemistry, 2014-05, Vol.57 (9), p.3818-3834

2014

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Hit-to-Lead Studies for the Antimalarial Tetrahydroisoquinolone Carboxanilides

Journal of medicinal chemistry, 2016-09, Vol.59 (17), p.7950-7962

2016

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3‑Hydroxy-propanamidines, a New Class of Orally Active Antimalarials Targeting Plasmodium falciparum

Journal of medicinal chemistry, 2021-03, Vol.64 (6), p.3035-3047

2021

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Discovery of Marinoquinolines as Potent and Fast-Acting Plasmodium falciparum Inhibitors with in Vivo Activity

Journal of medicinal chemistry, 2018-07, Vol.61 (13), p.5547-5568

2018

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Lead Optimization of Aryl and Aralkyl Amine-Based Triazolopyrimidine Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity in Mice

Journal of medicinal chemistry, 2011-06, Vol.54 (11), p.3935-3949

2011

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Synthesis, Structure–Activity Relationship, and Antimalarial Efficacy of 6‑Chloro-2-arylvinylquinolines

Journal of medicinal chemistry, 2020-10, Vol.63 (20), p.11756-11785

2020

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Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series

Journal of medicinal chemistry, 2021-05, Vol.64 (9), p.6085-6136

2021

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Comparative Antimalarial Activities and ADME Profiles of Ozonides (1,2,4-trioxolanes) OZ277, OZ439, and Their 1,2-Dioxolane, 1,2,4-Trioxane, and 1,2,4,5-Tetraoxane Isosteres

Journal of medicinal chemistry, 2013-03, Vol.56 (6), p.2547-2555

2013

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Synthesis and Structure–Activity Relationships of the Novel Antimalarials 5‑Pyridinyl-4(1H)‑Pyridones

Journal of medicinal chemistry, 2018-04, Vol.61 (8), p.3422-3435

2018

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Probing the Role of the Covalent Linkage of Ferrocene into a Chloroquine Template

Nonclassical Phenyl Bioisosteres as Effective Replacements in a Series of Novel Open-Source Antimalarials

Has Ferrocene Really Delivered Its Role in Accentuating the Bioactivity of Organic Scaffolds?

Artemisinin-Derived Dimers: Potent Antimalarial and Anticancer Agents

Accepting the Invitation to Open Innovation in Malaria Drug Discovery: Synthesis, Biological Evaluation, and Investigation on the Structure–Activity Relationships of Benzo[b]thiophene-2-carboxamides as Antimalarial Agents

Quinoline Drug–Heme Interactions and Implications for Antimalarial Cytostatic versus Cytocidal Activities

Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action

Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate

Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite

Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy

Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria

Quinoline–Pyrimidine Hybrids: Synthesis, Antiplasmodial Activity, SAR, and Mode of Action Studies

Aminoalkoxycarbonyloxymethyl Ether Prodrugs with a pH-Triggered Release Mechanism: A Case Study Improving the Solubility, Bioavailability, and Efficacy of Antimalarial 4(1H)‑Quinolones with Single Dose Cures

Synthesis and Structure–Activity Relationship of Dual-Stage Antimalarial Pyrazolo[3,4‑b]pyridines

Subtilisin-like Serine Protease 1 (SUB1) as an Emerging Antimalarial Drug Target: Current Achievements in Inhibitor Discovery

Discovery, Synthesis, and Optimization of Antimalarial 4(1H)‑Quinolone-3-Diarylethers

Hit-to-Lead Studies for the Antimalarial Tetrahydroisoquinolone Carboxanilides

3‑Hydroxy-propanamidines, a New Class of Orally Active Antimalarials Targeting Plasmodium falciparum

Discovery of Marinoquinolines as Potent and Fast-Acting Plasmodium falciparum Inhibitors with in Vivo Activity

Antimalarial Pyrido[1,2‑a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model

Lead Optimization of Aryl and Aralkyl Amine-Based Triazolopyrimidine Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity in Mice

Synthesis, Structure–Activity Relationship, and Antimalarial Efficacy of 6‑Chloro-2-arylvinylquinolines

Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series

Comparative Antimalarial Activities and ADME Profiles of Ozonides (1,2,4-trioxolanes) OZ277, OZ439, and Their 1,2-Dioxolane, 1,2,4-Trioxane, and 1,2,4,5-Tetraoxane Isosteres

Synthesis and Structure–Activity Relationships of the Novel Antimalarials 5‑Pyridinyl-4(1H)‑Pyridones

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