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Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis

Nature medicine, 2019-04, Vol.25 (4), p.690-700

2019

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Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases

Journal of medicinal chemistry, 2015-09, Vol.58 (18), p.7195-7216

2015

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Mycobacterial nicotinate mononucleotide adenylyltransferase: structure, mechanism, and implications for drug discovery

The Journal of biological chemistry, 2015-03, Vol.290 (12), p.7693-7706

2015

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2-N-Arylthiazole inhibitors of Mycobacterium tuberculosis

Bioorganic & medicinal chemistry letters, 2017-09, Vol.27 (17), p.3987-3991

2017

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A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors

Bioorganic & medicinal chemistry letters, 2010, Vol.20 (1), p.153-156

2010

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Janus Kinase 2 Inhibitors. Synthesis and Characterization of a Novel Polycyclic Azaindole

Journal of medicinal chemistry, 2009-12, Vol.52 (24), p.7938-7941

2009

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The Crystal Structure of an Unusual Processivity Factor, Herpes Simplex Virus UL42, Bound to the C Terminus of Its Cognate Polymerase

Molecular cell, 2000-02, Vol.5 (2), p.267-278

2000

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2-Aminopyrazolo[1,5- a]pyrimidines as potent and selective inhibitors of JAK2

Bioorganic & medicinal chemistry letters, 2009-12, Vol.19 (23), p.6529-6533

2009

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A Point Mutation within Conserved Region VI of Herpes Simplex Virus Type 1 DNA Polymerase Confers Altered Drug Sensitivity and Enhances Replication Fidelity

Journal of Virology, 2004-01, Vol.78 (2), p.650-657

2004

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Three-Dimensional Structure of Poliovirus Receptor Bound to Poliovirus

Proceedings of the National Academy of Sciences - PNAS, 2000-01, Vol.97 (1), p.73-78

2000

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Structural basis of the oligomerization of hepatitis delta antigen

Structure (London), 1998-07, Vol.6 (7), p.821-830

1998

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Correlation between chemotype-dependent binding conformations of HSP90α/β and isoform selectivity-Implications for the structure-based design of HSP90α/β selective inhibitors for treating neurodegenerative diseases

Bioorganic & medicinal chemistry letters, 2014-01, Vol.24 (1), p.204-208

2014

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Identification of Novel HSP90α/β Isoform Selective Inhibitors Using Structure-Based Drug Design. Demonstration of Potential Utility in Treating CNS Disorders such as Huntington’s Disease

Journal of medicinal chemistry, 2014-04, Vol.57 (8), p.3382-3400

2014

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Discovery and Optimization of Pyrazole Amides as Inhibitors of ELOVL1

Journal of medicinal chemistry, 2021-12, Vol.64 (24), p.17753-17776

2021

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Mtb PKNA/PKNB Dual Inhibition Provides Selectivity Advantages for Inhibitor Design To Minimize Host Kinase Interactions

ACS medicinal chemistry letters, 2017-12, Vol.8 (12), p.1224-1229

2017

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Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors

Bioorganic & medicinal chemistry letters, 2015-03, Vol.25 (6), p.1338-1342

2015

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The Enzymological Basis for Resistance of Herpesvirus DNA Polymerase Mutants to Acyclovir: Relationship to the Structure of α -like DNA Polymerases

Proceedings of the National Academy of Sciences - PNAS, 1999-01, Vol.96 (2), p.447-452

1999

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Mycobacterial Nicotinate Mononucleotide Adenylyltransferase

The Journal of biological chemistry, 2015-03, Vol.290 (12), p.7693-7706

2015

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Initiation of Hepatitis Delta Virus Genome Replication

Journal of Virology, 1998-06, Vol.72 (6), p.4783-4788

1998

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Interactions between Hepatitis Delta Virus Proteins

Journal of Virology, 2000-06, Vol.74 (12), p.5509-5515

2000

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Correlation between chemotype-dependent binding conformations of HSP90I-/I2 and isoform selectivityaImplications for the structure-based design of HSP90I-/I2 selective inhibitors for treating neurodegenerative diseases

Bioorganic & medicinal chemistry letters, 2014-01, Vol.24 (1), p.204-208

2014

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Corrigendum to “A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors” [Bioorg. Med. Chem. Lett. 20 (2010) 153]

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (8), p.2684-2684

2010

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A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors T.W. would like to dedicate this Letter to his PhD mentor, Professor Zhengming Li of Nankai University, Tianjin, China, in honor of his more than 50 years of teaching and research in organic chemistry

Bioorganic & medicinal chemistry letters, 2010-01, Vol.20 (1), p.153-156

2010

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Computational design of D-peptide inhibitors of hepatitis delta antigen dimerization

Journal of computer-aided molecular design, 2000-11, Vol.14 (8), p.705-718

2000

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ChemInform Abstract: A Novel Chemotype of Kinase Inhibitors: Discovery of 3,4-Ring Fused 7-Azaindoles and Deazapurines as Potent JAK2 Inhibitors

ChemInform, 2010-05, Vol.41 (21), p.no-no

2010

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Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis

Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases

Mycobacterial nicotinate mononucleotide adenylyltransferase: structure, mechanism, and implications for drug discovery

2-N-Arylthiazole inhibitors of Mycobacterium tuberculosis

A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors

Janus Kinase 2 Inhibitors. Synthesis and Characterization of a Novel Polycyclic Azaindole

The Crystal Structure of an Unusual Processivity Factor, Herpes Simplex Virus UL42, Bound to the C Terminus of Its Cognate Polymerase

2-Aminopyrazolo[1,5- a]pyrimidines as potent and selective inhibitors of JAK2

A Point Mutation within Conserved Region VI of Herpes Simplex Virus Type 1 DNA Polymerase Confers Altered Drug Sensitivity and Enhances Replication Fidelity

Three-Dimensional Structure of Poliovirus Receptor Bound to Poliovirus

Structural basis of the oligomerization of hepatitis delta antigen

Correlation between chemotype-dependent binding conformations of HSP90α/β and isoform selectivity-Implications for the structure-based design of HSP90α/β selective inhibitors for treating neurodegenerative diseases

Identification of Novel HSP90α/β Isoform Selective Inhibitors Using Structure-Based Drug Design. Demonstration of Potential Utility in Treating CNS Disorders such as Huntington’s Disease

Discovery and Optimization of Pyrazole Amides as Inhibitors of ELOVL1

Mtb PKNA/PKNB Dual Inhibition Provides Selectivity Advantages for Inhibitor Design To Minimize Host Kinase Interactions

Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors

The Enzymological Basis for Resistance of Herpesvirus DNA Polymerase Mutants to Acyclovir: Relationship to the Structure of α -like DNA Polymerases

Mycobacterial Nicotinate Mononucleotide Adenylyltransferase

Initiation of Hepatitis Delta Virus Genome Replication

Interactions between Hepatitis Delta Virus Proteins

Correlation between chemotype-dependent binding conformations of HSP90I-/I2 and isoform selectivityaImplications for the structure-based design of HSP90I-/I2 selective inhibitors for treating neurodegenerative diseases

Corrigendum to “A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors” [Bioorg. Med. Chem. Lett. 20 (2010) 153]

Computational design of D-peptide inhibitors of hepatitis delta antigen dimerization

ChemInform Abstract: A Novel Chemotype of Kinase Inhibitors: Discovery of 3,4-Ring Fused 7-Azaindoles and Deazapurines as Potent JAK2 Inhibitors

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