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The Intestinal Absorption of a Prodrug of the mGlu2/3 Receptor Agonist LY354740 is Mediated by PEPT1: In Situ Rat Intestinal Perfusion Studies

Journal of pharmaceutical sciences, 2010-03, Vol.99 (3), p.1574-1581

2010

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An integrated PK‐PD model for cortisol and the 17‐hydroxyprogesterone and androstenedione biomarkers in children with congenital adrenal hyperplasia

British journal of clinical pharmacology, 2021-03, Vol.87 (3), p.1098-1110

2021

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Transepithelial transport of the group II metabotropic glutamate 2/3 receptor agonist (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY354740) and its prodrug (1S,2S,5R,6S)-2-[(2'S)-(2'-amino)propionyl]aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY544344)

Drug metabolism and disposition, 2009-01, Vol.37 (1), p.211

2009

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Interrelationships Among Cortisol, 17-Hydroxyprogesterone, and Androstenendione Exposures in the Management of Children With Congenital Adrenal Hyperplasia

Journal of investigative medicine, 2015-01, Vol.63 (1), p.35-41

2015

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Comparison of cortisol exposures and pharmacodynamic adrenal steroid responses to hydrocortisone suspension vs. commercial tablets

Journal of clinical pharmacology, 2015-04, Vol.55 (4), p.452-457

2015

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In vivo-formed versus preformed metabolite kinetics of trans-resveratrol-3-sulfate and trans-resveratrol-3-glucuronide

Drug metabolism and disposition, 2012-10, Vol.40 (10), p.1993

2012

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Metabolism of opioids is altered in liver microsomes of sickle cell transgenic mice

Drug metabolism and disposition, 2004-01, Vol.32 (1), p.98

2004

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CK2 targeted RNAi therapeutic delivered via malignant cell-directed tenfibgen nanocapsule: dose and molecular mechanisms of response in xenograft prostate tumors

Oncotarget, 2016-09, Vol.7 (38), p.61789-61805

2016

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Phenanthrene metabolism in smokers: use of a two-step diagnostic plot approach to identify subjects with extensive metabolic activation

The Journal of pharmacology and experimental therapeutics, 2012-09, Vol.342 (3), p.750

2012

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Intestinal metabolism: the role of enzyme localization in phenol metabolite kinetics

Drug metabolism and disposition, 2002-05, Vol.30 (5), p.586

2002

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Formation and distribution of NNK metabolites in an isolated perfused rat lung

Drug metabolism and disposition, 2010-05, Vol.38 (5), p.752

2010

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Pharmacokinetics of Amino Acid Phosphoramidate Monoesters of Zidovudine in Rats

Antimicrobial Agents and Chemotherapy, 2002-05, Vol.46 (5), p.1357-1363

2002

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Effects of reduced cigarette smoking on the uptake of a tobacco-specific lung carcinogen

JNCI : Journal of the National Cancer Institute, 2004-01, Vol.96 (2), p.107-115

2004

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Quantitation of urinary metabolites of a tobacco-specific lung carcinogen after smoking cessation

Cancer research (Chicago, Ill.), 1999-02, Vol.59 (3), p.590-596

1999

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Quantitation of metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone after cessation of smokeless tobacco use

Cancer research (Chicago, Ill.), 2002, Vol.62 (1), p.129-134

2002

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Stereoselective metabolism and tissue retention in rats of the individual enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), metabolites of the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

Carcinogenesis (New York), 2004-07, Vol.25 (7), p.1237-1242

2004

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Metabolism and pharmacokinetics of N'-nitrosonornicotine in the patas monkey

Drug metabolism and disposition, 2002-10, Vol.30 (10), p.1115

2002

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Disposition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in bile duct-cannulated rats: Stereoselective metabolism and tissue distribution

Carcinogenesis (New York), 2002-01, Vol.23 (1), p.171-179

2002

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Disposition and oral bioavailability in rats of an antiviral and antitumor amino acid phosphoramidate prodrug of AZT-monophosphate

Pharmaceutical research, 2003-03, Vol.20 (3), p.448-451

2003

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First-pass disposition of (-)-6-aminocarbovir in rats: II. Inhibition of intestinal first-pass metabolism

Drug metabolism and disposition, 2000-06, Vol.28 (6), p.672

2000

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Methotrexate accumulates to similar levels in animals transplanted with normal versus drug-resistant transgenic marrow

Cancer research (Chicago, Ill.), 2001-02, Vol.61 (4), p.1522-1526

2001

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The intestinal uptake of phenol from micellar systems does not conform to the aqueous transfer model

Pharmaceutical research, 2000-07, Vol.17 (7), p.839-843

2000

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Use of the deconvolution principle in the estimation of absorption and pre-systemic intestinal elimination of drugs

Drug metabolism and disposition, 1997-11, Vol.25 (11), p.1260

1997

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The absorption of retinoic acids from the gastrointestinal tract is dependent upon chemical structure

Cancer chemotherapy and pharmacology, 2001, Vol.47 (1), p.27-33

2001

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Abstract 1696: Metabolism of (S)- NNAL and (R)- NNAL in the isolated perfused rat lung system

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.1696-1696

2010

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The Intestinal Absorption of a Prodrug of the mGlu2/3 Receptor Agonist LY354740 is Mediated by PEPT1: In Situ Rat Intestinal Perfusion Studies

An integrated PK‐PD model for cortisol and the 17‐hydroxyprogesterone and androstenedione biomarkers in children with congenital adrenal hyperplasia

Transepithelial transport of the group II metabotropic glutamate 2/3 receptor agonist (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY354740) and its prodrug (1S,2S,5R,6S)-2-[(2'S)-(2'-amino)propionyl]aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY544344)

Interrelationships Among Cortisol, 17-Hydroxyprogesterone, and Androstenendione Exposures in the Management of Children With Congenital Adrenal Hyperplasia

Comparison of cortisol exposures and pharmacodynamic adrenal steroid responses to hydrocortisone suspension vs. commercial tablets

In vivo-formed versus preformed metabolite kinetics of trans-resveratrol-3-sulfate and trans-resveratrol-3-glucuronide

Metabolism of opioids is altered in liver microsomes of sickle cell transgenic mice

CK2 targeted RNAi therapeutic delivered via malignant cell-directed tenfibgen nanocapsule: dose and molecular mechanisms of response in xenograft prostate tumors

Phenanthrene metabolism in smokers: use of a two-step diagnostic plot approach to identify subjects with extensive metabolic activation

Intestinal metabolism: the role of enzyme localization in phenol metabolite kinetics

Formation and distribution of NNK metabolites in an isolated perfused rat lung

Pharmacokinetics of Amino Acid Phosphoramidate Monoesters of Zidovudine in Rats

Effects of reduced cigarette smoking on the uptake of a tobacco-specific lung carcinogen

Quantitation of urinary metabolites of a tobacco-specific lung carcinogen after smoking cessation

Quantitation of metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone after cessation of smokeless tobacco use

Stereoselective metabolism and tissue retention in rats of the individual enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), metabolites of the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

Metabolism and pharmacokinetics of N'-nitrosonornicotine in the patas monkey

Disposition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in bile duct-cannulated rats: Stereoselective metabolism and tissue distribution

Disposition and oral bioavailability in rats of an antiviral and antitumor amino acid phosphoramidate prodrug of AZT-monophosphate

First-pass disposition of (-)-6-aminocarbovir in rats: II. Inhibition of intestinal first-pass metabolism

Methotrexate accumulates to similar levels in animals transplanted with normal versus drug-resistant transgenic marrow

The intestinal uptake of phenol from micellar systems does not conform to the aqueous transfer model

Use of the deconvolution principle in the estimation of absorption and pre-systemic intestinal elimination of drugs

The absorption of retinoic acids from the gastrointestinal tract is dependent upon chemical structure

Abstract 1696: Metabolism of (S)- NNAL and (R)- NNAL in the isolated perfused rat lung system

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