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Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)-Based Proteomics of Drug-Metabolizing Enzymes and Transporters

Molecules (Basel, Switzerland), 2020-06, Vol.25 (11), p.2718

2020

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Transplacental methadone exposure and risk of Neonatal Opioid Withdrawal Syndrome

Pharmacotherapy, 2024-01, Vol.44 (1), p.22-27

2024

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Genome-wide pQTL analysis of protein expression regulatory networks in the human liver

BMC biology, 2020-08, Vol.18 (1), p.97-97, Article 97

2020

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Identification of regulatory variants of carboxylesterase 1 (CES1): A proof‐of‐concept study for the application of the Allele‐Specific Protein Expression (ASPE) assay in identifying cis‐acting regulatory genetic polymorphisms

Proteomics (Weinheim), 2023-01, Vol.23 (1), p.e2200176-n/a

2023

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FRACPRED‐2D‐PRM: A Fraction Prediction Algorithm‐Assisted 2D Liquid Chromatography‐Based Parallel Reaction Monitoring‐Mass Spectrometry Approach for Measuring Low‐Abundance Proteins in Human Plasma

Proteomics (Weinheim), 2020-12, Vol.20 (24), p.e2000175-n/a

2020

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Functional Study of Carboxylesterase 1 Protein Isoforms

Proteomics (Weinheim), 2019-02, Vol.19 (4), p.e1800288-n/a

2019

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Comparison of protein expression between human livers and the hepatic cell lines HepG2, Hep3B, and Huh7 using SWATH and MRM-HR proteomics: Focusing on drug-metabolizing enzymes

Drug metabolism and pharmacokinetics, 2018-04, Vol.33 (2), p.133-140

2018

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Dabigatran etexilate activation is affected by the CES1 genetic polymorphism G143E (rs71647871) and gender

Biochemical pharmacology, 2016-11, Vol.119, p.76-84

2016

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Plasma Carboxylesterase 1 Predicts Methylphenidate Exposure: A Proof‐of‐Concept Study Using Plasma Protein Biomarker for Hepatic Drug Metabolism

Clinical pharmacology and therapeutics, 2022-04, Vol.111 (4), p.878-885

2022

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Carboxylesterase 1 and Precision Pharmacotherapy: Pharmacogenetics and Nongenetic Regulators

Drug metabolism and disposition, 2020-03, Vol.48 (3), p.230-244

2020

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Tissue‐ and cell‐expression of druggable host proteins provide insights into repurposing drugs for COVID‐19

Clinical and translational science, 2022-12, Vol.15 (12), p.2796-2811

2022

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Targeted absolute quantitative proteomics with SILAC internal standards and unlabeled full-length protein calibrators (TAQSI)

Rapid communications in mass spectrometry, 2016-03, Vol.30 (5), p.553-561

2016

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Absolute Quantitation of Drug-Metabolizing Cytochrome P450 Enzymes and Accessory Proteins in Dog Liver Microsomes Using Label-Free Standard-Free Analysis Reveals Interbreed Variability

Drug metabolism and disposition, 2019-11, Vol.47 (11), p.1314-1324

2019

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Determining Allele-Specific Protein Expression (ASPE) Using a Novel Quantitative Concatamer Based Proteomics Method

Journal of proteome research, 2018-10, Vol.17 (10), p.3606-3612

2018

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A Comprehensive Functional Assessment of Carboxylesterase 1 Nonsynonymous Polymorphisms

Drug metabolism and disposition, 2017-11, Vol.45 (11), p.1149-1155

2017

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Effect of CES1 genetic variation on enalapril steady‐state pharmacokinetics and pharmacodynamics in healthy subjects

British journal of clinical pharmacology, 2021-12, Vol.87 (12), p.4691-4700

2021

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Association of Oseltamivir Activation with Gender and Carboxylesterase 1 Genetic Polymorphisms

Basic & clinical pharmacology & toxicology, 2016-12, Vol.119 (6), p.555-561

2016

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An assessment of pharmacokinetics and antioxidant activity of free silymarin flavonolignans in healthy volunteers: a dose escalation study

Drug metabolism and disposition, 2013-09, Vol.41 (9), p.1679

2013

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Carboxylesterase 1-Mediated Drug–Drug Interactions between Clopidogrel and Simvastatin

Biological and Pharmaceutical Bulletin, 2015/02/01, Vol.38(2), pp.292-297

2015

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Activation of Tenofovir Alafenamide and Sofosbuvir in the Human Lung and Its Implications in the Development of Nucleoside/Nucleotide Prodrugs for Treating SARS-CoV-2 Pulmonary Infection

Pharmaceutics, 2021-10, Vol.13 (10), p.1656

2021

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Impact of carboxylesterase 1 genetic polymorphism on trandolapril activation in human liver and the pharmacokinetics and pharmacodynamics in healthy volunteers

Clinical and translational science, 2021-07, Vol.14 (4), p.1380-1389

2021

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Activation of the antiviral prodrug oseltamivir is impaired by two newly identified carboxylesterase 1 variants

Drug metabolism and disposition, 2009-02, Vol.37 (2), p.264

2009

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Influence of peptide transporter 2 (PEPT2) on the distribution of cefadroxil in mouse brain: A microdialysis study

Biochemical pharmacology, 2017-05, Vol.131, p.89-97

2017

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Depolarization and repolarization parameters on ECG predict recurrence after atrial fibrillation ablation in patients with hypertrophic cardiomyopathy

Journal of cardiovascular electrophysiology, 2019-11, Vol.30 (11), p.2405-2413

2019

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Two CES1 Gene Mutations Lead to Dysfunctional Carboxylesterase 1 Activity in Man: Clinical Significance and Molecular Basis

American journal of human genetics, 2008-06, Vol.82 (6), p.1241-1248

2008

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Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)-Based Proteomics of Drug-Metabolizing Enzymes and Transporters

Transplacental methadone exposure and risk of Neonatal Opioid Withdrawal Syndrome

Genome-wide pQTL analysis of protein expression regulatory networks in the human liver

Identification of regulatory variants of carboxylesterase 1 (CES1): A proof‐of‐concept study for the application of the Allele‐Specific Protein Expression (ASPE) assay in identifying cis‐acting regulatory genetic polymorphisms

FRACPRED‐2D‐PRM: A Fraction Prediction Algorithm‐Assisted 2D Liquid Chromatography‐Based Parallel Reaction Monitoring‐Mass Spectrometry Approach for Measuring Low‐Abundance Proteins in Human Plasma

Functional Study of Carboxylesterase 1 Protein Isoforms

Comparison of protein expression between human livers and the hepatic cell lines HepG2, Hep3B, and Huh7 using SWATH and MRM-HR proteomics: Focusing on drug-metabolizing enzymes

Dabigatran etexilate activation is affected by the CES1 genetic polymorphism G143E (rs71647871) and gender

Plasma Carboxylesterase 1 Predicts Methylphenidate Exposure: A Proof‐of‐Concept Study Using Plasma Protein Biomarker for Hepatic Drug Metabolism

Carboxylesterase 1 and Precision Pharmacotherapy: Pharmacogenetics and Nongenetic Regulators

Tissue‐ and cell‐expression of druggable host proteins provide insights into repurposing drugs for COVID‐19

Targeted absolute quantitative proteomics with SILAC internal standards and unlabeled full-length protein calibrators (TAQSI)

Absolute Quantitation of Drug-Metabolizing Cytochrome P450 Enzymes and Accessory Proteins in Dog Liver Microsomes Using Label-Free Standard-Free Analysis Reveals Interbreed Variability

Determining Allele-Specific Protein Expression (ASPE) Using a Novel Quantitative Concatamer Based Proteomics Method

A Comprehensive Functional Assessment of Carboxylesterase 1 Nonsynonymous Polymorphisms

Effect of CES1 genetic variation on enalapril steady‐state pharmacokinetics and pharmacodynamics in healthy subjects

Association of Oseltamivir Activation with Gender and Carboxylesterase 1 Genetic Polymorphisms

An assessment of pharmacokinetics and antioxidant activity of free silymarin flavonolignans in healthy volunteers: a dose escalation study

Carboxylesterase 1-Mediated Drug–Drug Interactions between Clopidogrel and Simvastatin

Activation of Tenofovir Alafenamide and Sofosbuvir in the Human Lung and Its Implications in the Development of Nucleoside/Nucleotide Prodrugs for Treating SARS-CoV-2 Pulmonary Infection

Impact of carboxylesterase 1 genetic polymorphism on trandolapril activation in human liver and the pharmacokinetics and pharmacodynamics in healthy volunteers

Activation of the antiviral prodrug oseltamivir is impaired by two newly identified carboxylesterase 1 variants

Influence of peptide transporter 2 (PEPT2) on the distribution of cefadroxil in mouse brain: A microdialysis study

Depolarization and repolarization parameters on ECG predict recurrence after atrial fibrillation ablation in patients with hypertrophic cardiomyopathy

Two CES1 Gene Mutations Lead to Dysfunctional Carboxylesterase 1 Activity in Man: Clinical Significance and Molecular Basis

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