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Drugging an undruggable pocket on KRAS

Proceedings of the National Academy of Sciences - PNAS, 2019-08, Vol.116 (32), p.15823-15829

2019

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Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor

Journal of medicinal chemistry, 2016-05, Vol.59 (10), p.4462-4475

2016

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One Question, Multiple Answers: Biochemical and Biophysical Screening Methods Retrieve Deviating Fragment Hit Lists

ChemMedChem, 2015-09, Vol.10 (9), p.1511-1521

2015

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Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis

Proceedings of the National Academy of Sciences - PNAS, 2020-12, Vol.117 (52), p.33272-33281

2020

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Folding and Association of an Extremely Stable Dimeric Protein from Sulfolobus islandicus

Journal of molecular biology, 2004-02, Vol.336 (1), p.227-240

2004

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Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain

Journal of medicinal chemistry, 2021-11, Vol.64 (21), p.15629-15638

2021

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Structural Basis for Interaction of the Tandem Zinc Finger Domains of Human Muscleblind with Cognate RNA from Human Cardiac Troponin T

Biochemistry (Easton), 2017-08, Vol.56 (32), p.4154-4168

2017

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One Target—Two Different Binding Modes: Structural Insights into Gevokizumab and Canakinumab Interactions to Interleukin-1β

Journal of molecular biology, 2013-01, Vol.425 (1), p.94-111

2013

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A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I

Proceedings of the National Academy of Sciences - PNAS, 2020-12, Vol.117 (50), p.31838-31849

2020

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A hybrid screening approach for very small fragments - X-ray and Computational Screening on FKBP51

Journal of medicinal chemistry, 2020-06, Vol.63 (11), p.5856-5864

2020

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Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (STEP, PTPN5) by a Fragment-like Molecule

Journal of medicinal chemistry, 2019-01, Vol.62 (1), p.306-316

2019

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REPLY TO TRAN ET AL: Dimeric KRAS protein–protein interaction stabilizers

Proceedings of the National Academy of Sciences - PNAS, 2020-02, Vol.117 (7), p.3365-3367

2020

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Cooperativity of a Protein Folding Reaction Probed at Multiple Chain Positions by Real-Time 2D NMR Spectroscopy

Biochemistry (Easton), 2000-07, Vol.39 (27), p.7910-7919

2000

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Protein folding studied by real-time NMR spectroscopy

Methods (San Diego, Calif.), 2004-09, Vol.34 (1), p.65-74

2004

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NMR Spectroscopic Characterization of Millisecond Protein Folding by Transverse Relaxation Dispersion Measurements

Journal of the American Chemical Society, 2005-09, Vol.127 (38), p.13207-13212

2005

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MALDI-TOF-Based Affinity Selection Mass Spectrometry for Automated Screening of Protein–Ligand Interactions at High Throughput

SLAS discovery, 2021-01, Vol.26 (1), p.44-57

2021

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Common mode of DNA binding to cold shock domains. Crystal structure of hexathymidine bound to the domain-swapped form of a major cold shock protein from Bacillus caldolyticus

The FEBS journal, 2007-03, Vol.274 (5), p.1265-1279

2007

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T-rich DNA Single Strands Bind to a Preformed Site on the Bacterial Cold Shock Protein Bs-CspB

Journal of molecular biology, 2006-07, Vol.360 (3), p.702-714

2006

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Single‐stranded DNA binding of the cold‐shock protein CspB from Bacillus subtilis: NMR mapping and mutational characterization

Protein science, 2003-01, Vol.12 (1), p.112-123

2003

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Folding mechanism of an ankyrin repeat protein: scaffold and active site formation of human CDK inhibitor p19(INK4d)

Journal of molecular biology, 2007-10, Vol.373 (1), p.219-231

2007

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Molecular structure of human GM-CSF in complex with a disease-associated anti-human GM-CSF autoantibody and its potential biological implications

Biochemical journal, 2012-10, Vol.447 (2), p.205-215

2012

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Structure-Based Stability Analysis of an Extremely Stable Dimeric DNA Binding Protein from Sulfolobus islandicus

Biochemistry (Easton), 2009-10, Vol.48 (42), p.10030-10037

2009

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Drugging an undruggable pocket on KRAS

Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor

One Question, Multiple Answers: Biochemical and Biophysical Screening Methods Retrieve Deviating Fragment Hit Lists

Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis

Folding and Association of an Extremely Stable Dimeric Protein from Sulfolobus islandicus

Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain

Structural Basis for Interaction of the Tandem Zinc Finger Domains of Human Muscleblind with Cognate RNA from Human Cardiac Troponin T

One Target—Two Different Binding Modes: Structural Insights into Gevokizumab and Canakinumab Interactions to Interleukin-1β

A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I

A hybrid screening approach for very small fragments - X-ray and Computational Screening on FKBP51

Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (STEP, PTPN5) by a Fragment-like Molecule

Getting a Grip on the Undrugged: Targeting β‐Catenin with Fragment‐Based Methods

REPLY TO TRAN ET AL: Dimeric KRAS protein–protein interaction stabilizers

Cooperativity of a Protein Folding Reaction Probed at Multiple Chain Positions by Real-Time 2D NMR Spectroscopy

Front Cover: Getting a Grip on the Undrugged: Targeting β‐Catenin with Fragment‐Based Methods (9/2021)

Getting a Grip on the Undrugged: Targeting [beta]-Catenin with Fragment-Based Methods

Protein folding studied by real-time NMR spectroscopy

NMR Spectroscopic Characterization of Millisecond Protein Folding by Transverse Relaxation Dispersion Measurements

MALDI-TOF-Based Affinity Selection Mass Spectrometry for Automated Screening of Protein–Ligand Interactions at High Throughput

Common mode of DNA binding to cold shock domains. Crystal structure of hexathymidine bound to the domain-swapped form of a major cold shock protein from Bacillus caldolyticus

T-rich DNA Single Strands Bind to a Preformed Site on the Bacterial Cold Shock Protein Bs-CspB

Single‐stranded DNA binding of the cold‐shock protein CspB from Bacillus subtilis: NMR mapping and mutational characterization

Folding mechanism of an ankyrin repeat protein: scaffold and active site formation of human CDK inhibitor p19(INK4d)

Molecular structure of human GM-CSF in complex with a disease-associated anti-human GM-CSF autoantibody and its potential biological implications

Structure-Based Stability Analysis of an Extremely Stable Dimeric DNA Binding Protein from Sulfolobus islandicus

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