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Cell-based high-throughput screening for the evaluation of reactive metabolite formation potential

Toxicology in vitro, 2021-08, Vol.74, p.105159, Article 105159

2021

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Allylcyanation of Alkynes: Regio- and Stereoselective Access to Functionalized Di- or Trisubstituted Acrylonitriles

Journal of the American Chemical Society, 2006-06, Vol.128 (22), p.7116-7117

2006

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Utility of Physicochemical Properties for the Prediction of Toxicological Outcomes: Takeda Perspective

ACS medicinal chemistry letters, 2020-02, Vol.11 (2), p.203-209

2020

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Practical application of 3-substituted-2,6-difluoropyridines in drug discovery: Facile synthesis of novel protein kinase C theta inhibitors

Bioorganic & medicinal chemistry letters, 2017-06, Vol.27 (11), p.2497-2501

2017

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Nickel-Catalyzed Carbocyanation of Alkynes with Allyl Cyanides

Journal of the American Chemical Society, 2009-08, Vol.131 (31), p.10964-10973

2009

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Stannylative Cycloaddition of Enynes Catalyzed by Palladium−Iminophosphine

Journal of the American Chemical Society, 2004-12, Vol.126 (48), p.15650-15651

2004

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Freshly isolated primary human proximal tubule cells as an in vitro model for the detection of renal tubular toxicity

Toxicology (Amsterdam), 2020-09, Vol.442, p.152535, Article 152535

2020

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Small-Scale Panel Comprising Diverse Gene Family Targets To Evaluate Compound Promiscuity

Chemical research in toxicology, 2020-01, Vol.33 (1), p.154-161

2020

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Nickel/AlMe2Cl-catalysed carbocyanation of alkynes using arylacetonitriles

Chemical communications (Cambridge, England), 2009 (26), p.3931

2009

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Discovery of [cis-3-({(5R)‑5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro‑1H‑inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5H)‑yl}carbonyl)cyclobutyl]acetic Acid (TAK-828F) as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist

Journal of medicinal chemistry, 2018-04, Vol.61 (7), p.2973-2988

2018

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New phenotypic cytotoxicity assay for ROS-inducing compounds using rat renal epithelial cells

Toxicology letters, 2020-10, Vol.331, p.227-234

2020

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Design, Synthesis, and Biological Evaluation of Retinoic Acid-Related Orphan Receptor γt (RORγt) Agonist Structure-Based Functionality Switching Approach from In House RORγt Inverse Agonist to RORγt Agonist

Journal of medicinal chemistry, 2019-02, Vol.62 (3), p.1167-1179

2019

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Discovery of orally efficacious RORγt inverse agonists. Part 2: Design, synthesis, and biological evaluation of novel tetrahydroisoquinoline derivatives

Bioorganic & medicinal chemistry, 2018-01, Vol.26 (2), p.470-482

2018

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Assessment of a 3D neural spheroid model to detect pharmaceutical-induced neurotoxicity

ALTEX, alternatives to animal experimentation, 2022-01, Vol.39 (4), p.560

2022

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Design, synthesis, and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitors – Part 3

Bioorganic & medicinal chemistry, 2016-08, Vol.24 (16), p.3716-3726

2016

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Design, synthesis, and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitors—Part 2

Bioorganic & medicinal chemistry, 2016-07, Vol.24 (14), p.3207-3217

2016

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Design, synthesis and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitor

Bioorganic & medicinal chemistry, 2015-08, Vol.23 (15), p.5000-5014

2015

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Nickel/AlMe(2)Cl-catalysed carbocyanation of alkynes using arylacetonitriles

Chemical communications (Cambridge, England), 2009-07 (26), p.3931-3933

2009

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ChemInform Abstract: Nickel/Lewis Acid-Catalyzed Carbocyanation of Alkynes Using Acetonitrile and Substituted Acetonitriles

ChemInform, 2010-10, Vol.41 (42), p.no-no

2010

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ChemInform Abstract: Nickel-Catalyzed Carbocyanation of Alkynes with Allyl Cyanides

ChemInform, 2009-12, Vol.40 (52), p.no-no

2009

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ChemInform Abstract: Nickel-Catalyzed Carbocyanation of Alkynes with Allyl Cyanides

ChemInform, 2009-12, Vol.40 (52), p.no-no

2009

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ChemInform Abstract: Nickel/AlMe2Cl-Catalyzed Carbocyanation of Alkynes Using Arylacetonitriles

ChemInform, 2009-11, Vol.40 (46), p.no-no

2009

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ChemInform Abstract: Nickel/AlMe 2 Cl‐Catalyzed Carbocyanation of Alkynes Using Arylacetonitriles

ChemInform, 2009-11, Vol.40 (46)

2009

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Allylcyanation of Alkynes: Regio- and Stereoselective Access to Functionalized Di- or Trisubstituted Acrylonitriles

ChemInform, 2006-10, Vol.37 (41), p.no-no

2006

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Stannylative Cycloaddition of Enynes Catalyzed by Palladium-Iminophosphine

ChemInform, 2005-04, Vol.36 (17), p.no-no

2005

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Cell-based high-throughput screening for the evaluation of reactive metabolite formation potential

Allylcyanation of Alkynes: Regio- and Stereoselective Access to Functionalized Di- or Trisubstituted Acrylonitriles

Utility of Physicochemical Properties for the Prediction of Toxicological Outcomes: Takeda Perspective

Practical application of 3-substituted-2,6-difluoropyridines in drug discovery: Facile synthesis of novel protein kinase C theta inhibitors

Nickel-Catalyzed Carbocyanation of Alkynes with Allyl Cyanides

Stannylative Cycloaddition of Enynes Catalyzed by Palladium−Iminophosphine

Freshly isolated primary human proximal tubule cells as an in vitro model for the detection of renal tubular toxicity

Small-Scale Panel Comprising Diverse Gene Family Targets To Evaluate Compound Promiscuity

Nickel/AlMe2Cl-catalysed carbocyanation of alkynes using arylacetonitriles

New phenotypic cytotoxicity assay for ROS-inducing compounds using rat renal epithelial cells

Design, Synthesis, and Biological Evaluation of Retinoic Acid-Related Orphan Receptor γt (RORγt) Agonist Structure-Based Functionality Switching Approach from In House RORγt Inverse Agonist to RORγt Agonist

Discovery of orally efficacious RORγt inverse agonists. Part 2: Design, synthesis, and biological evaluation of novel tetrahydroisoquinoline derivatives

Assessment of a 3D neural spheroid model to detect pharmaceutical-induced neurotoxicity

Design, synthesis, and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitors – Part 3

Design, synthesis, and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitors—Part 2

Design, synthesis and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitor

Nickel/AlMe(2)Cl-catalysed carbocyanation of alkynes using arylacetonitriles

ChemInform Abstract: Nickel/Lewis Acid-Catalyzed Carbocyanation of Alkynes Using Acetonitrile and Substituted Acetonitriles

ChemInform Abstract: Nickel-Catalyzed Carbocyanation of Alkynes with Allyl Cyanides

ChemInform Abstract: Nickel-Catalyzed Carbocyanation of Alkynes with Allyl Cyanides

ChemInform Abstract: Nickel/AlMe2Cl-Catalyzed Carbocyanation of Alkynes Using Arylacetonitriles

ChemInform Abstract: Nickel/AlMe 2 Cl‐Catalyzed Carbocyanation of Alkynes Using Arylacetonitriles

Allylcyanation of Alkynes: Regio- and Stereoselective Access to Functionalized Di- or Trisubstituted Acrylonitriles

Stannylative Cycloaddition of Enynes Catalyzed by Palladium-Iminophosphine

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