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Target protection as a key antibiotic resistance mechanism

Nature reviews. Microbiology, 2020-11, Vol.18 (11), p.637-648

2020

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Tetracycline antibiotics and resistance mechanisms

Biological chemistry, 2014-05, Vol.395 (5), p.559

2014

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Structure of Gcn1 bound to stalled and colliding 80S ribosomes

Proceedings of the National Academy of Sciences - PNAS, 2021-04, Vol.118 (14)

2021

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Translation Elongation Factor EF-P Alleviates Ribosome Stalling at Polyproline Stretches

Science (American Association for the Advancement of Science), 2013-01, Vol.339 (6115), p.82-85

2013

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Bacterial Protein Synthesis as a Target for Antibiotic Inhibition

Cold Spring Harbor perspectives in medicine, 2016-09, Vol.6 (9), p.a025361

2016

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The ABC of Ribosome-Related Antibiotic Resistance

mBio, 2016-05, Vol.7 (3)

Wilson, Daniel N

2016

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Structures of the human and Drosophila 80S ribosome

Nature (London), 2013-05, Vol.497 (7447), p.80-85

2013

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Ribosome-targeting antibiotics and mechanisms of bacterial resistance

Nature reviews. Microbiology, 2014-01, Vol.12 (1), p.35-48

Wilson, Daniel N

2014

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Mechanisms of SecM-Mediated Stalling in the Ribosome

Biophysical journal, 2012-07, Vol.103 (2), p.331-341

2012

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Drug Sensing by the Ribosome Induces Translational Arrest via Active Site Perturbation

Molecular cell, 2014-11, Vol.56 (3), p.446-452

2014

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Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis

Proceedings of the National Academy of Sciences - PNAS, 2013-03, Vol.110 (10), p.3812-3816

2013

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The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis

Nucleic acids research, 2016-07, Vol.44 (13), p.6471

2016

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Structural Basis for Ribosome Rescue in Bacteria

Trends in biochemical sciences (Amsterdam. Regular ed.), 2017-08, Vol.42 (8), p.669-680

2017

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Structure of Escherichia coli heat shock protein Hsp15 in complex with the ribosomal 50S subunit bearing peptidyl-tRNA

Nucleic acids research, 2022-11, Vol.50 (21), p.12515

2022

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The Dolphin Proline-Rich Antimicrobial Peptide Tur1A Inhibits Protein Synthesis by Targeting the Bacterial Ribosome

Cell chemical biology, 2018-05, Vol.25 (5), p.530-539.e7

2018

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Structural basis for TetM-mediated tetracycline resistance

Proceedings of the National Academy of Sciences - PNAS, 2012-10, Vol.109 (42), p.16900-16905

2012

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Structural Basis for Bacterial Ribosome-Associated Quality Control by RqcH and RqcP

Molecular cell, 2021-01, Vol.81 (1), p.115-126.e7

2021

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A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest

Nature communications, 2016-07, Vol.7 (1), p.12026-14, Article 12026

2016

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Structure of the hypusinylated eukaryotic translation factor eIF-5A bound to the ribosome

Nucleic acids research, 2016-02, Vol.44 (4), p.1944

2016

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Structure of the Bacillus subtilis 70S ribosome reveals the basis for species-specific stalling

Nature communications, 2015-04, Vol.6 (1), p.6941-6941, Article 6941

2015

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Visualization of translation termination intermediates trapped by the Apidaecin 137 peptide during RF3-mediated recycling of RF1

Nature communications, 2018-08, Vol.9 (1), p.3053-11, Article 3053

2018

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Distinct XPPX sequence motifs induce ribosome stalling, which is rescued by the translation elongation factor EF-P

Proceedings of the National Academy of Sciences - PNAS, 2013-09, Vol.110 (38), p.15265-15270

2013

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Release factor-dependent ribosome rescue by BrfA in the Gram-positive bacterium Bacillus subtilis

Nature communications, 2019-11, Vol.10 (1), p.5397-14, Article 5397

2019

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Structural Basis for Polyproline-Mediated Ribosome Stalling and Rescue by the Translation Elongation Factor EF-P

Molecular cell, 2017-11, Vol.68 (3), p.515-527.e6

2017

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Structure of the mammalian antimicrobial peptide Bac7(1-16) bound within the exit tunnel of a bacterial ribosome

Nucleic acids research, 2016-03, Vol.44 (5), p.2429

2016

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Target protection as a key antibiotic resistance mechanism

Tetracycline antibiotics and resistance mechanisms

Structure of Gcn1 bound to stalled and colliding 80S ribosomes

Translation Elongation Factor EF-P Alleviates Ribosome Stalling at Polyproline Stretches

Bacterial Protein Synthesis as a Target for Antibiotic Inhibition

The ABC of Ribosome-Related Antibiotic Resistance

Structures of the human and Drosophila 80S ribosome

Ribosome-targeting antibiotics and mechanisms of bacterial resistance

Mechanisms of SecM-Mediated Stalling in the Ribosome

Drug Sensing by the Ribosome Induces Translational Arrest via Active Site Perturbation

Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis

The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis

Structural Basis for Ribosome Rescue in Bacteria

Structure of Escherichia coli heat shock protein Hsp15 in complex with the ribosomal 50S subunit bearing peptidyl-tRNA

The Dolphin Proline-Rich Antimicrobial Peptide Tur1A Inhibits Protein Synthesis by Targeting the Bacterial Ribosome

Structural basis for TetM-mediated tetracycline resistance

Structural Basis for Bacterial Ribosome-Associated Quality Control by RqcH and RqcP

A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest

Structure of the hypusinylated eukaryotic translation factor eIF-5A bound to the ribosome

Structure of the Bacillus subtilis 70S ribosome reveals the basis for species-specific stalling

Visualization of translation termination intermediates trapped by the Apidaecin 137 peptide during RF3-mediated recycling of RF1

Distinct XPPX sequence motifs induce ribosome stalling, which is rescued by the translation elongation factor EF-P

Release factor-dependent ribosome rescue by BrfA in the Gram-positive bacterium Bacillus subtilis

Structural Basis for Polyproline-Mediated Ribosome Stalling and Rescue by the Translation Elongation Factor EF-P

Structure of the mammalian antimicrobial peptide Bac7(1-16) bound within the exit tunnel of a bacterial ribosome

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