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Targeting TGF-β Mediated SMAD Signaling for the Prevention of Fibrosis

Frontiers in pharmacology, 2017-07, Vol.8, p.461-461

2017

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Elevated expression of activins promotes muscle wasting and cachexia

The FASEB journal, 2014-04, Vol.28 (4), p.1711-1723

2014

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Structural basis for potency differences between GDF8 and GDF11

BMC biology, 2017-03, Vol.15 (1), p.19-19, Article 19

2017

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Engineering the Ovarian Hormones Inhibin A and Inhibin B to Enhance Synthesis and Activity

Endocrinology (Philadelphia), 2020-08, Vol.161 (8), p.1

2020

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Molecular characterization of latent GDF8 reveals mechanisms of activation

Proceedings of the National Academy of Sciences - PNAS, 2018-01, Vol.115 (5), p.E866-E875

2018

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Two Distinct Regions of Latency-associated Peptide Coordinate Stability of the Latent Transforming Growth Factor-β1 Complex

The Journal of biological chemistry, 2010-05, Vol.285 (22), p.17029-17037

2010

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TMEPAI/PMEPA1 Is a Positive Regulator of Skeletal Muscle Mass

Frontiers in physiology, 2020-11, Vol.11, p.560225-560225

2020

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Activin Signaling Regulates Sertoli Cell Differentiation and Function

Endocrinology (Philadelphia), 2012-12, Vol.153 (12), p.6065-6077

2012

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Hormonal Regulation of Sertoli Cell Micro-RNAs at Spermiation

Endocrinology (Philadelphia), 2011-04, Vol.152 (4), p.1670-1683

2011

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Species Differences in the Expression and Activity of Bone Morphogenetic Protein 15

Endocrinology (Philadelphia), 2013-02, Vol.154 (2), p.888-899

2013

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Activation of Latent Human GDF9 by a Single Residue Change (Gly391Arg) in the Mature Domain

Endocrinology (Philadelphia), 2012-03, Vol.153 (3), p.1301-1310

2012

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Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease

Proceedings of the National Academy of Sciences - PNAS, 2017-06, Vol.114 (26), p.E5266-E5275

2017

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Targeting activins and inhibins to treat reproductive disorders and cancer cachexia

Journal of endocrinology, 2023-07, Vol.258 (1)

2023

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Inhibin B Is a More Potent Suppressor of Rat Follicle-Stimulating Hormone Release than Inhibin A in Vitro and in Vivo

Endocrinology (Philadelphia), 2009-10, Vol.150 (10), p.4784-4793

2009

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New insights into the mechanisms of activin action and inhibition

Molecular and cellular endocrinology, 2012-08, Vol.359 (1-2), p.2-12

2012

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Suppression of Inhibin A Biological Activity by Alterations in the Binding Site for Betaglycan

The Journal of biological chemistry, 2008-06, Vol.283 (24), p.16743-16751

2008

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Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia

Cancer research (Chicago, Ill.), 2016-09, Vol.76 (18), p.5372-5382

2016

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Inhibin: To Betaglycan, or Not to Betaglycan

Endocrinology (Philadelphia), 2019-02, Vol.160 (2), p.341-342

2019

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Structure of AMH bound to AMHR2 provides insight into a unique signaling pair in the TGF-β family

Proceedings of the National Academy of Sciences - PNAS, 2021-06, Vol.118 (26)

2021

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A variant of human growth differentiation factor-9 that improves oocyte developmental competence

The Journal of biological chemistry, 2020-06, Vol.295 (23), p.7981-7991

2020

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Characterization of the molecular mechanisms that govern anti‐Müllerian hormone synthesis and activity

The FASEB journal, 2024-01, Vol.38 (1), p.e23377-n/a

2024

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Inhibin Inactivation in Female Mice Leads to Elevated FSH Levels, Ovarian Overstimulation, and Pregnancy Loss

Endocrinology (Philadelphia), 2022-04, Vol.163 (4), p.1

2022

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Activin A–Induced Cachectic Wasting Is Attenuated by Systemic Delivery of Its Cognate Propeptide in Male Mice

Endocrinology (Philadelphia), 2019-10, Vol.160 (10), p.2417-2426

2019

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Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice

Science translational medicine, 2016-07, Vol.8 (348), p.348ra98

2016

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Follistatin Forms a Stable Complex With Inhibin A That Does Not Interfere With Activin A Antagonism

Endocrinology (Philadelphia), 2023-01, Vol.164 (3)

2023

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Targeting TGF-β Mediated SMAD Signaling for the Prevention of Fibrosis

Elevated expression of activins promotes muscle wasting and cachexia

Structural basis for potency differences between GDF8 and GDF11

Engineering the Ovarian Hormones Inhibin A and Inhibin B to Enhance Synthesis and Activity

Molecular characterization of latent GDF8 reveals mechanisms of activation

Two Distinct Regions of Latency-associated Peptide Coordinate Stability of the Latent Transforming Growth Factor-β1 Complex

TMEPAI/PMEPA1 Is a Positive Regulator of Skeletal Muscle Mass

Activin Signaling Regulates Sertoli Cell Differentiation and Function

Hormonal Regulation of Sertoli Cell Micro-RNAs at Spermiation

Species Differences in the Expression and Activity of Bone Morphogenetic Protein 15

Activation of Latent Human GDF9 by a Single Residue Change (Gly391Arg) in the Mature Domain

Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease

Targeting activins and inhibins to treat reproductive disorders and cancer cachexia

Inhibin B Is a More Potent Suppressor of Rat Follicle-Stimulating Hormone Release than Inhibin A in Vitro and in Vivo

New insights into the mechanisms of activin action and inhibition

Suppression of Inhibin A Biological Activity by Alterations in the Binding Site for Betaglycan

Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia

Inhibin: To Betaglycan, or Not to Betaglycan

Structure of AMH bound to AMHR2 provides insight into a unique signaling pair in the TGF-β family

A variant of human growth differentiation factor-9 that improves oocyte developmental competence

Characterization of the molecular mechanisms that govern anti‐Müllerian hormone synthesis and activity

Inhibin Inactivation in Female Mice Leads to Elevated FSH Levels, Ovarian Overstimulation, and Pregnancy Loss

Activin A–Induced Cachectic Wasting Is Attenuated by Systemic Delivery of Its Cognate Propeptide in Male Mice

Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice

Follistatin Forms a Stable Complex With Inhibin A That Does Not Interfere With Activin A Antagonism

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