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Gut Microbiota as a Trigger for Metabolic Inflammation in Obesity and Type 2 Diabetes

Frontiers in immunology, 2020-10, Vol.11, p.571731-571731

2020

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The Flavanol (−)-Epigallocatechin 3-Gallate Inhibits Amyloid Formation by Islet Amyloid Polypeptide, Disaggregates Amyloid Fibrils, and Protects Cultured Cells against IAPP-Induced Toxicity

Biochemistry (Easton), 2010-09, Vol.49 (37), p.8127-8133

2010

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Improving glycaemic control in type 2 diabetes: Stimulate insulin secretion or provide beta‐cell rest?

Diabetes, obesity & metabolism, 2017-09, Vol.19 (9), p.1205-1213

2017

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Elevated islet prohormone ratios as indicators of insulin dependency in auto‐islet transplant recipients

American journal of transplantation, 2022-08, Vol.22 (8), p.1992-2005

2022

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Islet prohormone processing in health and disease

Diabetes, obesity & metabolism, 2018-09, Vol.20 (S2), p.64-76

2018

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Top-Down Proteomics of Mouse Islets With Beta Cell CPE Deletion Reveals Molecular Details in Prohormone Processing

Endocrinology (Philadelphia), 2023-11, Vol.164 (12)

2023

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IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction

The Journal of immunology (1950), 2011-09, Vol.187 (5), p.2755-2765

2011

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Interactions between islets and regulatory immune cells in health and type 1 diabetes

Diabetologia, 2021-11, Vol.64 (11), p.2378-2388

2021

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Loss of Cyp8b1 improves glucose homeostasis by increasing GLP-1

Diabetes (New York, N.Y.), 2015-04, Vol.64 (4), p.1168-1179

2015

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Maternal folic acid supplementation with vitamin B 12 deficiency during pregnancy and lactation affects the metabolic health of adult female offspring but is dependent on offspring diet

The FASEB journal, 2018-09, Vol.32 (9), p.5039-5050

2018

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AAV GCG-EGFP, a new tool to identify glucagon-secreting α-cells

Scientific reports, 2019-07, Vol.9 (1), p.10829-11, Article 10829

2019

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Tregs with an MHC class II peptide-specific chimeric antigen receptor prevent autoimmune diabetes in mice

The Journal of clinical investigation, 2023-09, Vol.133 (18), p.1

2023

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Metabolic stress, IAPP and islet amyloid

Diabetes, obesity & metabolism, 2012-10, Vol.14 (s3), p.68-77

2012

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miR-33a Modulates ABCA1 Expression, Cholesterol Accumulation, and Insulin Secretion in Pancreatic Islets

Diabetes (New York, N.Y.), 2012-03, Vol.61 (3), p.653-658

2012

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Thioredoxin-interacting Protein Promotes Islet Amyloid Polypeptide Expression through miR-124a and FoxA2

The Journal of biological chemistry, 2014-04, Vol.289 (17), p.11807-11815

2014

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IL-1 mediates amyloid-associated islet dysfunction and inflammation in human islet amyloid polypeptide transgenic mice

Diabetologia, 2015-03, Vol.58 (3), p.575-585

2015

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A human antibody against pathologic IAPP aggregates protects beta cells in type 2 diabetes models

Nature communications, 2023-10, Vol.14 (1), p.6294-6294, Article 6294

2023

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Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules

Diabetes (New York, N.Y.), 2011-12, Vol.60 (12), p.3186-3196

2011

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PAM haploinsufficiency does not accelerate the development of diet- and human IAPP-induced diabetes in mice

Diabetologia, 2020-03, Vol.63 (3), p.561-576

2020

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A Call for Improved Reporting of Human Islet Characteristics in Research Articles

Diabetes (New York, N.Y.), 2019-02, Vol.68 (2), p.239-240

2019

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Cellular mechanisms of CCL22-mediated attenuation of autoimmune diabetes

The Journal of immunology (1950), 2015-04, Vol.194 (7), p.3054-3064

2015

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Islet remodeling in female mice with spontaneous autoimmune and streptozotocin-induced diabetes

PloS one, 2014-08, Vol.9 (8), p.e102843-e102843

2014

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B7-H4 Treatment of T Cells Inhibits ERK, JNK, p38, and AKT Activation

PloS one, 2012-01, Vol.7 (1), p.e28232

2012

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Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets

The Journal of clinical investigation, 2011-08, Vol.121 (8), p.3024-3028

2011

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Gut Microbiota as a Trigger for Metabolic Inflammation in Obesity and Type 2 Diabetes

The Flavanol (−)-Epigallocatechin 3-Gallate Inhibits Amyloid Formation by Islet Amyloid Polypeptide, Disaggregates Amyloid Fibrils, and Protects Cultured Cells against IAPP-Induced Toxicity

Improving glycaemic control in type 2 diabetes: Stimulate insulin secretion or provide beta‐cell rest?

Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics

Elevated islet prohormone ratios as indicators of insulin dependency in auto‐islet transplant recipients

Islet prohormone processing in health and disease

Top-Down Proteomics of Mouse Islets With Beta Cell CPE Deletion Reveals Molecular Details in Prohormone Processing

IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction

Interactions between islets and regulatory immune cells in health and type 1 diabetes

Loss of Cyp8b1 improves glucose homeostasis by increasing GLP-1

Maternal folic acid supplementation with vitamin B 12 deficiency during pregnancy and lactation affects the metabolic health of adult female offspring but is dependent on offspring diet

AAV GCG-EGFP, a new tool to identify glucagon-secreting α-cells

Tregs with an MHC class II peptide-specific chimeric antigen receptor prevent autoimmune diabetes in mice

Metabolic stress, IAPP and islet amyloid

miR-33a Modulates ABCA1 Expression, Cholesterol Accumulation, and Insulin Secretion in Pancreatic Islets

Thioredoxin-interacting Protein Promotes Islet Amyloid Polypeptide Expression through miR-124a and FoxA2

IL-1 mediates amyloid-associated islet dysfunction and inflammation in human islet amyloid polypeptide transgenic mice

A human antibody against pathologic IAPP aggregates protects beta cells in type 2 diabetes models

Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules

PAM haploinsufficiency does not accelerate the development of diet- and human IAPP-induced diabetes in mice

A Call for Improved Reporting of Human Islet Characteristics in Research Articles

Cellular mechanisms of CCL22-mediated attenuation of autoimmune diabetes

Islet remodeling in female mice with spontaneous autoimmune and streptozotocin-induced diabetes

B7-H4 Treatment of T Cells Inhibits ERK, JNK, p38, and AKT Activation

Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets

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