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The BACE‐1 inhibitor CNP520 for prevention trials in Alzheimer's disease

EMBO molecular medicine, 2018-11, Vol.10 (11), p.n/a

2018

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Discovery of Umibecestat (CNP520): A Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor for the Prevention of Alzheimer's Disease

Journal of medicinal chemistry, 2021-10, Vol.64 (20), p.15262-15279

2021

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Synthesis of the Potent, Selective, and Efficacious β‑Secretase (BACE1) Inhibitor NB-360

Journal of medicinal chemistry, 2021-04, Vol.64 (8), p.4677-4696

2021

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Organoboron compounds in organic synthesis. 1. Asymmetric hydroboration

Journal of the American Chemical Society, , Vol.107 (15), p.4549-4551

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5-aminomethylquinoxaline-2,3-diones. Part II: N-aryl derivatives as novel NMDA/glycine and AMPA antagonists

Bioorganic & medicinal chemistry letters, 1998-01, Vol.8 (1), p.71-74

1998

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A stereoselective synthesis of indole alkaloid intermediates via N-acyliminium cyclizations

Journal of the American Chemical Society, , Vol.103 (15), p.4645-4646

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One-pot synthesis of protected homoallyl amines

Tetrahedron letters, 1997-02, Vol.38 (6), p.997-1000

1997

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Diastereoselective, One-Pot Synthesis of γ-Amino Alcohols from Ketimines

Synlett, 2001, Vol.2001 (7), p.1109-1112

2001

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N-Phosphonoalkyl-5-aminomethylquinoxaline-2,3-diones: In vivo active AMPA and NMDA(glycine) antagonists

Bioorganic & medicinal chemistry letters, 1999-01, Vol.9 (2), p.249-254

1999

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Efficient and stereoselective synthesis of 2,3-dihydroindoles via 1,5-electrocyclization

Journal of the American Chemical Society, 1981-07, Vol.103 (15), p.4643-4645

1981

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5-aminomethylquinoxaline-2,3-diones. Part I: A novel class of AMPA receptor antagonists

Bioorganic & medicinal chemistry letters, 1998-01, Vol.8 (1), p.65-70

1998

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SAR of 2-benzyl-4-aminopiperidines: CGP 49823, an orally and centrally active non-peptide NK1 antagonist

Bioorganic & medicinal chemistry letters, 1996-07, Vol.6 (14), p.1623-1628

1996

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Studies on the active conformation of the NK1 antagonist CGP 49823. Part 2. Fluoro-olefin analogs of tertiary amide rotamers

Bioorganic & medicinal chemistry letters, 1997-02, Vol.7 (3), p.351-354

1997

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Studies on the active conformation of the NK1 antagonist CGP 49823. Part 21. Fluoro-olefin analogs of tertiary amide rotamers

Bioorganic & medicinal chemistry letters, 1997-02, Vol.7 (3), p.351-354

1997

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Studies on the active conformation of NK 1 antagonist CGP 49823. Part 1. Synthesis of conformationally restricted analogs

Bioorganic & medicinal chemistry letters, 1997, Vol.7 (3), p.347-350

1997

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Studies on the active conformation of the NK 1 antagonist CGP 49823. Part 2 1. Fluoro-olefin analogs of tertiary amide rotamers

Bioorganic & medicinal chemistry letters, 1997, Vol.7 (3), p.351-354

1997

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Studies on the active conformation of NK1 antagonist CGP 49823. Part 1. Synthesis of conformationally restricted analogs

Bioorganic & medicinal chemistry letters, 1997-02, Vol.7 (3), p.347-350

1997

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SAR of 2-benzyl-4-aminopiperidines NK1 antagonists. Part 21. synthesis of CGP 49823

Bioorganic & medicinal chemistry letters, 1996-12, Vol.6 (24), p.3029-3034

1996

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Enantioselective 1,5-electrocyclization. Synthesis of optically active indolines

Journal of the Chemical Society. Chemical communications, 1982 (7), p.369

1982

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SAR of 2-benzyl-4-aminopiperidines NK 1 antagonists. Part 2 1. synthesis of CGP 49823

Bioorganic & medicinal chemistry letters, 1996, Vol.6 (24), p.3029-3034

1996

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SAR of 2-benzyl-4-aminopiperidines: CGP 49823, an orally and centrally active non-peptide NK 1 antagonist

Bioorganic & medicinal chemistry letters, 1996, Vol.6 (14), p.1623-1628

1996

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Intramolecular [2+2] cycloadditions of vinylketenes to olefins. Part II. The synthesis of a linear annelated triquinane derivative

Tetrahedron letters, 1988, Vol.29 (4), p.459-462

1988

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ChemInform Abstract: Diastereoselective, One-Pot Synthesis of γ-Amino Alcohols from Ketimines

ChemInform, 2001-10, Vol.32 (42), p.no-no

2001

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Intramolecular [2+2] cycloadditions of ketenes and vinylketenes to olefins - III. The synthesis of angular annulated triquinane derivatives

Tetrahedron letters, 1988, Vol.29 (19), p.2303-2306

1988

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The BACE‐1 inhibitor CNP520 for prevention trials in Alzheimer's disease

Discovery of Umibecestat (CNP520): A Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor for the Prevention of Alzheimer's Disease

Synthesis of the Potent, Selective, and Efficacious β‑Secretase (BACE1) Inhibitor NB-360

Organoboron compounds in organic synthesis. 1. Asymmetric hydroboration

5-aminomethylquinoxaline-2,3-diones. Part II: N-aryl derivatives as novel NMDA/glycine and AMPA antagonists

A stereoselective synthesis of indole alkaloid intermediates via N-acyliminium cyclizations

The BACE ‐1 inhibitor CNP 520 for prevention trials in Alzheimer's disease

One-pot synthesis of protected homoallyl amines

Diastereoselective, One-Pot Synthesis of γ-Amino Alcohols from Ketimines

N-Phosphonoalkyl-5-aminomethylquinoxaline-2,3-diones: In vivo active AMPA and NMDA(glycine) antagonists

Efficient and stereoselective synthesis of 2,3-dihydroindoles via 1,5-electrocyclization

5-aminomethylquinoxaline-2,3-diones. Part I: A novel class of AMPA receptor antagonists

SAR of 2-benzyl-4-aminopiperidines: CGP 49823, an orally and centrally active non-peptide NK1 antagonist

Studies on the active conformation of the NK1 antagonist CGP 49823. Part 2. Fluoro-olefin analogs of tertiary amide rotamers

Studies on the active conformation of the NK1 antagonist CGP 49823. Part 21. Fluoro-olefin analogs of tertiary amide rotamers

Studies on the active conformation of NK 1 antagonist CGP 49823. Part 1. Synthesis of conformationally restricted analogs

Studies on the active conformation of the NK 1 antagonist CGP 49823. Part 2 1. Fluoro-olefin analogs of tertiary amide rotamers

Studies on the active conformation of NK1 antagonist CGP 49823. Part 1. Synthesis of conformationally restricted analogs

SAR of 2-benzyl-4-aminopiperidines NK1 antagonists. Part 21. synthesis of CGP 49823

Enantioselective 1,5-electrocyclization. Synthesis of optically active indolines

SAR of 2-benzyl-4-aminopiperidines NK 1 antagonists. Part 2 1. synthesis of CGP 49823

SAR of 2-benzyl-4-aminopiperidines: CGP 49823, an orally and centrally active non-peptide NK 1 antagonist

Intramolecular [2+2] cycloadditions of vinylketenes to olefins. Part II. The synthesis of a linear annelated triquinane derivative

ChemInform Abstract: Diastereoselective, One-Pot Synthesis of γ-Amino Alcohols from Ketimines

Intramolecular [2+2] cycloadditions of ketenes and vinylketenes to olefins - III. The synthesis of angular annulated triquinane derivatives

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