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Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase

Cancer research (Chicago, Ill.), 2004-06, Vol.64 (11), p.3958-3965

2004

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Optimization of 6,7-Disubstituted-4-(arylamino)quinoline-3-carbonitriles as Orally Active, Irreversible Inhibitors of Human Epidermal Growth Factor Receptor-2 Kinase Activity

Journal of medicinal chemistry, 2005-02, Vol.48 (4), p.1107-1131

2005

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Gemtuzumab Ozogamicin, A Potent and Selective Anti-CD33 Antibody−Calicheamicin Conjugate for Treatment of Acute Myeloid Leukemia

Bioconjugate chemistry, 2002-01, Vol.13 (1), p.47-58

2002

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Palladium-catalyzed arylation of N, N-dialkylhydrazines and the subsequent conversion to anilines

Tetrahedron letters, 2007-11, Vol.48 (48), p.8409-8412

2007

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4-(Phenylaminomethylene)isoquinoline-1,3(2H,4H)-diones as Potent and Selective Inhibitors of the Cyclin-Dependent Kinase 4 (CDK4)

Journal of medicinal chemistry, 2008-06, Vol.51 (12), p.3507-3525

2008

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Discovery and optimization of 2-(4-substituted-pyrrolo[2,3- b]pyridin-3-yl)methylene-4-hydroxybenzofuran-3(2 H)-ones as potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR)

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (7), p.2321-2325

2010

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4-Substituted-7-azaindoles bearing a ureidobenzofuranone moiety as potent and selective, ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR)

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (7), p.2259-2263

2010

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Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment

Bioorganic & medicinal chemistry letters, 2008-06, Vol.18 (12), p.3641-3645

2008

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Pyrazolo[1,5- a]pyrimidin-7-yl phenyl amides as novel anti-proliferative agents: parallel synthesis for lead optimization of amide region

Bioorganic & medicinal chemistry letters, 2005-03, Vol.15 (6), p.1591-1594

2005

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Syntheses and EGFR and HER-2 kinase inhibitory activities of 4-anilinoquinoline-3-carbonitriles: Analogues of three important 4-anilinoquinazolines currently undergoing clinical evaluation as therapeutic antitumor agents

Bioorganic & medicinal chemistry letters, 2002-10, Vol.12 (20), p.2893-2897

2002

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Discovery of 4-(Benzylaminomethylene)isoquinoline-1,3-(2H,4H)-diones and 4-[(Pyridylmethyl)aminomethylene]isoquinoline-1,3-(2H,4H)-diones as Potent and Selective Inhibitors of the Cyclin-Dependent Kinase 4

Journal of medicinal chemistry, 2009-04, Vol.52 (8), p.2289-2310

2009

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Determination of the loading values for high levels of drugs and sugars conjugated to proteins by matrix-assisted ultraviolet laser desorption/ionization mass spectrometry

Biological Mass Spectrometry, 1993-07, Vol.22 (7), p.369-376

1993

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6-Substituted-4-(3-bromophenylamino)quinazolines as Putative Irreversible Inhibitors of the Epidermal Growth Factor Receptor (EGFR) and Human Epidermal Growth Factor Receptor (HER-2) Tyrosine Kinases with Enhanced Antitumor Activity

Journal of medicinal chemistry, 2001-08, Vol.44 (17), p.2719-2734

2001

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ChemInform Abstract: Palladium-Catalyzed Arylation of N,N-Dialkylhydrazines and the Subsequent Conversion to Anilines

ChemInform, 2008-03, Vol.39 (11), p.no-no

2008

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THE UTILIZATION OF MOLECULAR OXYGEN DURING THE BIOSYNTHESIS OF MADURAMICIN

The Journal of Antibiotics, 1987/01/25, Vol.40(1), pp.94-99

1987

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4-Anilino-6,7-dialkoxyquinoline-3-carbonitrile Inhibitors of Epidermal Growth Factor Receptor Kinase and Their Bioisosteric Relationship to the 4-Anilino-6,7-dialkoxyquinazoline Inhibitors

Journal of medicinal chemistry, 2000-08, Vol.43 (17), p.3244-3256

2000

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Procedure for diethoxymethylation of ketones

Journal of organic chemistry, 1981-06, Vol.46 (12), p.2557-2561

1981

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A novel synthesis of α-N-methyl-14C-DL-asparagine by generation of methylamine-14C insitu

Journal of labelled compounds & radiopharmaceuticals, 1981-06, Vol.18 (6), p.921-923

Tsou, Hwei-Ru

1981

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Pyrazolo[1,5-a]pyrimidin-7-yl Phenyl Amides as Novel Antiproliferative Agents: Parallel Synthesis for Lead Optimization of Amide Region

ChemInform, 2005-07, Vol.36 (29), p.no-no

2005

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Natural abundance two-dimensional double-quantum 13C NMR spectroscopy of maduramicin, a polyether ionophore antibiotic and coccidiostat

Journal of antibiotics, 1984, Vol.37 (11), p.1495-1500

1984

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ChemInform Abstract: 6-Substituted-4-(3-bromophenylamino)quinazolines as Putative Irreversible Inhibitors of the Epidermal Growth Factor Receptor (EGFR) and Human Epidermal Growth Factor Receptor (HER-2) Tyrosine Kinases with Enhanced Antitumor Activity

ChemInform, 2001-12, Vol.32 (49), p.no-no

2001

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Studies on the role of protein synthesis and of sodium on the regulation of ornithine decarboxylase activity

Biochimica et biophysica acta, 1982-08, Vol.717 (2), p.305-315

1982

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Syntheses and EGFR and HER-2 Kinase Inhibitory Activities of 4-Anilinoquinoline-3-carbonitriles: Analogues of Three Important 4-Anilinoquinazolines Currently Undergoing Clinical Evaluation as Therapeutic Antitumor Agents

ChemInform, 2003-03, Vol.34 (9), p.no-no

2003

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BIOSYNTHESIS OF THE ANTIBIOTIC MADURAMICIN: ORIGIN OF THE CARBON AND OXYGEN ATOMS AS WELL AS THE 13C NMR ASSIGNMENTS

The Journal of Antibiotics, 1984, Vol.37(12), pp.1651-1663

1984

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Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase

Optimization of 6,7-Disubstituted-4-(arylamino)quinoline-3-carbonitriles as Orally Active, Irreversible Inhibitors of Human Epidermal Growth Factor Receptor-2 Kinase Activity

Gemtuzumab Ozogamicin, A Potent and Selective Anti-CD33 Antibody−Calicheamicin Conjugate for Treatment of Acute Myeloid Leukemia

Synthesis and Structure−Activity Relationships of 6,7-Disubstituted 4-Anilinoquinoline-3-carbonitriles. The Design of an Orally Active, Irreversible Inhibitor of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor (EGFR) and the Human Epidermal Growth Factor Receptor-2 (HER-2)

Palladium-catalyzed arylation of N, N-dialkylhydrazines and the subsequent conversion to anilines

4-(Phenylaminomethylene)isoquinoline-1,3(2H,4H)-diones as Potent and Selective Inhibitors of the Cyclin-Dependent Kinase 4 (CDK4)

Discovery and optimization of 2-(4-substituted-pyrrolo[2,3- b]pyridin-3-yl)methylene-4-hydroxybenzofuran-3(2 H)-ones as potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR)

4-Substituted-7-azaindoles bearing a ureidobenzofuranone moiety as potent and selective, ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR)

Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment

Pyrazolo[1,5- a]pyrimidin-7-yl phenyl amides as novel anti-proliferative agents: parallel synthesis for lead optimization of amide region

Syntheses and EGFR and HER-2 kinase inhibitory activities of 4-anilinoquinoline-3-carbonitriles: Analogues of three important 4-anilinoquinazolines currently undergoing clinical evaluation as therapeutic antitumor agents

Discovery of 4-(Benzylaminomethylene)isoquinoline-1,3-(2H,4H)-diones and 4-[(Pyridylmethyl)aminomethylene]isoquinoline-1,3-(2H,4H)-diones as Potent and Selective Inhibitors of the Cyclin-Dependent Kinase 4

Determination of the loading values for high levels of drugs and sugars conjugated to proteins by matrix-assisted ultraviolet laser desorption/ionization mass spectrometry

6-Substituted-4-(3-bromophenylamino)quinazolines as Putative Irreversible Inhibitors of the Epidermal Growth Factor Receptor (EGFR) and Human Epidermal Growth Factor Receptor (HER-2) Tyrosine Kinases with Enhanced Antitumor Activity

ChemInform Abstract: Palladium-Catalyzed Arylation of N,N-Dialkylhydrazines and the Subsequent Conversion to Anilines

THE UTILIZATION OF MOLECULAR OXYGEN DURING THE BIOSYNTHESIS OF MADURAMICIN

4-Anilino-6,7-dialkoxyquinoline-3-carbonitrile Inhibitors of Epidermal Growth Factor Receptor Kinase and Their Bioisosteric Relationship to the 4-Anilino-6,7-dialkoxyquinazoline Inhibitors

Procedure for diethoxymethylation of ketones

A novel synthesis of α-N-methyl-14C-DL-asparagine by generation of methylamine-14C insitu

Pyrazolo[1,5-a]pyrimidin-7-yl Phenyl Amides as Novel Antiproliferative Agents: Parallel Synthesis for Lead Optimization of Amide Region

Natural abundance two-dimensional double-quantum 13C NMR spectroscopy of maduramicin, a polyether ionophore antibiotic and coccidiostat

ChemInform Abstract: 6-Substituted-4-(3-bromophenylamino)quinazolines as Putative Irreversible Inhibitors of the Epidermal Growth Factor Receptor (EGFR) and Human Epidermal Growth Factor Receptor (HER-2) Tyrosine Kinases with Enhanced Antitumor Activity

Studies on the role of protein synthesis and of sodium on the regulation of ornithine decarboxylase activity

Syntheses and EGFR and HER-2 Kinase Inhibitory Activities of 4-Anilinoquinoline-3-carbonitriles: Analogues of Three Important 4-Anilinoquinazolines Currently Undergoing Clinical Evaluation as Therapeutic Antitumor Agents

BIOSYNTHESIS OF THE ANTIBIOTIC MADURAMICIN: ORIGIN OF THE CARBON AND OXYGEN ATOMS AS WELL AS THE 13C NMR ASSIGNMENTS

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