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Rhodanine as a scaffold in drug discovery: a critical review of its biological activities and mechanisms of target modulation

Expert opinion on drug discovery, 2012-07, Vol.7 (7), p.549-560

2012

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ATP-Binding Site of Bacterial Enzymes as a Target for Antibacterial Drug Design

Journal of medicinal chemistry, 2011-02, Vol.54 (4), p.915-929

2011

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Novel Potent and Selective Thrombin Inhibitors Based on a Central 1,4-Benzoxazin-3(4H)-one Scaffold

Journal of medicinal chemistry, 2008-05, Vol.51 (9), p.2863-2867

2008

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Dual Inhibitor of MurD and MurE Ligases from Escherichia coli and Staphylococcus aureus

ACS medicinal chemistry letters, 2012-08, Vol.3 (8), p.626-630

2012

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Bazedoxifene-Scaffold-Based Mimetics of Solomonsterols A and B as Novel Pregnane X Receptor Antagonists

Journal of medicinal chemistry, 2014-06, Vol.57 (11), p.4819-4833

2014

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Following the design path of isoform-selective Hsp90 inhibitors: Small differences, great opportunities

Pharmacology & therapeutics (Oxford), 2023-05, Vol.245, p.108396-108396, Article 108396

2023

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Efflux pump inhibitors of clinically relevant multidrug resistant bacteria

Medicinal research reviews, 2019-11, Vol.39 (6), p.2460-2504

2019

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6-Arylpyrido[2,3-d]pyrimidines as novel ATP-competitive inhibitors of bacterial D-alanine:D-alanine ligase

PloS one, 2012-08, Vol.7 (8), p.e39922

2012

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Prospects for developing new antibacterials targeting bacterial type IIA topoisomerases

Current topics in medicinal chemistry, 2014-01, Vol.14 (1), p.130

2014

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Discovery of Benzothiazole Scaffold-Based DNA Gyrase B Inhibitors

Journal of medicinal chemistry, 2016-10, Vol.59 (19), p.8941-8954

2016

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Catalytic performance of Noyori–Ikariya-type ruthenium complex with tethered syn-ULTAM ligand for the asymmetric transfer hydrogenation of ketones

Tetrahedron letters, 2024-03, Vol.138, Article 154984

2024

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Xanthine oxidase inhibitors beyond allopurinol and febuxostat; an overview and selection of potential leads based on in silico calculated physico-chemical properties, predicted pharmacokinetics and toxicity

European journal of medicinal chemistry, 2017-07, Vol.135, p.491-516

2017

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Discovery of 4,5,6,7-Tetrahydrobenzo[1,2‑d]thiazoles as Novel DNA Gyrase Inhibitors Targeting the ATP-Binding Site

Journal of medicinal chemistry, 2015-07, Vol.58 (14), p.5501-5521

2015

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Discovery of Novel 5-Benzylidenerhodanine and 5-Benzylidenethiazolidine-2,4-dione Inhibitors of MurD Ligase

Journal of medicinal chemistry, 2010-09, Vol.53 (18), p.6584-6594

2010

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ATP-competitive DNA gyrase and topoisomerase IV inhibitors as antibacterial agents

Expert opinion on therapeutic patents, 2019-03, Vol.29 (3), p.171-180

2019

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Discovery of Nanomolar Desmuramylpeptide Agonists of the Innate Immune Receptor Nucleotide-Binding Oligomerization Domain-Containing Protein 2 (NOD2) Possessing Immunostimulatory Properties

Journal of medicinal chemistry, 2018-04, Vol.61 (7), p.2707-2724

2018

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Last piece in the puzzle of bisphenols BPA, BPS and BPF metabolism: Kinetics of the in vitro sulfation reaction

Chemosphere (Oxford), 2022-09, Vol.303 (Pt 2), p.135133-135133, Article 135133

2022

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Virtual Screening Assisted Search for Inhibitors of the Translocated Intimin Receptor of Enteropathogenic Escherichia Coli

Chembiochem : a European journal of chemical biology, 2024-01, Vol.25 (2), p.e202300638-n/a

2024

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Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents

European journal of medicinal chemistry, 2019-10, Vol.179, p.576-590

2019

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Structure-Based Design of a New Series of d-Glutamic Acid Based Inhibitors of Bacterial UDP-N-acetylmuramoyl-l-alanine:d-glutamate Ligase (MurD)

Journal of medicinal chemistry, 2011-07, Vol.54 (13), p.4600-4610

2011

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Discovery of Novel Hsp90 C-Terminal Inhibitors Using 3D-Pharmacophores Derived from Molecular Dynamics Simulations

International journal of molecular sciences, 2020-09, Vol.21 (18), p.6898

2020

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New aryl and acylsulfonamides as state-dependent inhibitors of Nav1.3 voltage-gated sodium channel

European journal of medicinal chemistry, 2023-10, Vol.258, p.115530-115530, Article 115530

2023

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Optimisation of pyrazolo[1,5-a]pyrimidin-7(4H)-one derivatives as novel Hsp90 C-terminal domain inhibitors against Ewing sarcoma

Bioorganic chemistry, 2023-02, Vol.131, p.106311-106311, Article 106311

2023

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N‑Phenyl-4,5-dibromopyrrolamides and N‑Phenylindolamides as ATP Competitive DNA Gyrase B Inhibitors: Design, Synthesis, and Evaluation

Journal of medicinal chemistry, 2015-08, Vol.58 (15), p.6179-6194

2015

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Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa

Journal of medicinal chemistry, 2023-01, Vol.66 (2), p.1380-1425

2023

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Rhodanine as a scaffold in drug discovery: a critical review of its biological activities and mechanisms of target modulation

ATP-Binding Site of Bacterial Enzymes as a Target for Antibacterial Drug Design

Novel Potent and Selective Thrombin Inhibitors Based on a Central 1,4-Benzoxazin-3(4H)-one Scaffold

Dual Inhibitor of MurD and MurE Ligases from Escherichia coli and Staphylococcus aureus

Bazedoxifene-Scaffold-Based Mimetics of Solomonsterols A and B as Novel Pregnane X Receptor Antagonists

Following the design path of isoform-selective Hsp90 inhibitors: Small differences, great opportunities

Efflux pump inhibitors of clinically relevant multidrug resistant bacteria

6-Arylpyrido[2,3-d]pyrimidines as novel ATP-competitive inhibitors of bacterial D-alanine:D-alanine ligase

Prospects for developing new antibacterials targeting bacterial type IIA topoisomerases

Discovery of Benzothiazole Scaffold-Based DNA Gyrase B Inhibitors

Catalytic performance of Noyori–Ikariya-type ruthenium complex with tethered syn-ULTAM ligand for the asymmetric transfer hydrogenation of ketones

Xanthine oxidase inhibitors beyond allopurinol and febuxostat; an overview and selection of potential leads based on in silico calculated physico-chemical properties, predicted pharmacokinetics and toxicity

Discovery of 4,5,6,7-Tetrahydrobenzo[1,2‑d]thiazoles as Novel DNA Gyrase Inhibitors Targeting the ATP-Binding Site

Discovery of Novel 5-Benzylidenerhodanine and 5-Benzylidenethiazolidine-2,4-dione Inhibitors of MurD Ligase

ATP-competitive DNA gyrase and topoisomerase IV inhibitors as antibacterial agents

Discovery of Nanomolar Desmuramylpeptide Agonists of the Innate Immune Receptor Nucleotide-Binding Oligomerization Domain-Containing Protein 2 (NOD2) Possessing Immunostimulatory Properties

Last piece in the puzzle of bisphenols BPA, BPS and BPF metabolism: Kinetics of the in vitro sulfation reaction

Virtual Screening Assisted Search for Inhibitors of the Translocated Intimin Receptor of Enteropathogenic Escherichia Coli

Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents

Structure-Based Design of a New Series of d-Glutamic Acid Based Inhibitors of Bacterial UDP-N-acetylmuramoyl-l-alanine:d-glutamate Ligase (MurD)

Discovery of Novel Hsp90 C-Terminal Inhibitors Using 3D-Pharmacophores Derived from Molecular Dynamics Simulations

New aryl and acylsulfonamides as state-dependent inhibitors of Nav1.3 voltage-gated sodium channel

Optimisation of pyrazolo[1,5-a]pyrimidin-7(4H)-one derivatives as novel Hsp90 C-terminal domain inhibitors against Ewing sarcoma

N‑Phenyl-4,5-dibromopyrrolamides and N‑Phenylindolamides as ATP Competitive DNA Gyrase B Inhibitors: Design, Synthesis, and Evaluation

Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa

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