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Mechanisms Generating Cancer Genome Complexity: Back to the Future

Cancers, 2020-12, Vol.12 (12), p.3783

Toledo, Franck

2020

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The Guardian of the Genome Revisited: p53 Downregulates Genes Required for Telomere Maintenance, DNA Repair, and Centromere Structure

Cancers, 2018-05, Vol.10 (5), p.135

2018

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Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

Nature reviews. Cancer, 2006-12, Vol.6 (12), p.909-923

2006

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p53 in the Molecular Circuitry of Bone Marrow Failure Syndromes

International journal of molecular sciences, 2023-10, Vol.24 (19), p.14940

2023

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A systematic approach identifies p53-DREAM pathway target genes associated with blood or brain abnormalities

Disease models & mechanisms, 2023-10, Vol.16 (10)

2023

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p53 downregulates the Fanconi anaemia DNA repair pathway

Nature communications, 2016-04, Vol.7 (1), p.11091-11091, Article 11091

2016

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Targeting MDM4 Splicing in Cancers

Genes, 2017-02, Vol.8 (2), p.82

2017

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Essential role for centromeric factors following p53 loss and oncogenic transformation

Genes & development, 2017-03, Vol.31 (5), p.463-480

2017

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Mutant Mice Lacking the p53 C-Terminal Domain Model Telomere Syndromes

Cell reports (Cambridge), 2013-06, Vol.3 (6), p.2046-2058

2013

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The C-Terminal Lysines Fine-Tune P53 Stress Responses in a Mouse Model but Are Not Required for Stability Control or Transactivation

Proceedings of the National Academy of Sciences - PNAS, 2005-07, Vol.102 (29), p.10188-10193

2005

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p53: A two-faced regulator of telomere metabolism? (comment on DOI 10.1002/bies.201600078)

BioEssays, 2016-10, Vol.38 (10), p.938-938

Toledo, Franck

2016

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Fuzzy tandem repeats containing p53 response elements may define species-specific p53 target genes

PLoS genetics, 2012-06, Vol.8 (6), p.e1002731-e1002731

2012

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Expression of Fragile Sites Triggers Intrachromosomal Mammalian Gene Amplification and Sets Boundaries to Early Amplicons

Cell, 1997-04, Vol.89 (2), p.215-225

1997

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Mouse Mutants Reveal that Putative Protein Interaction Sites in the p53 Proline-Rich Domain Are Dispensable for Tumor Suppression

Molecular and Cellular Biology, 2007-02, Vol.27 (4), p.1425-1432

2007

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MDM2 and MDM4: p53 regulators as targets in anticancer therapy

The international journal of biochemistry & cell biology, 2007-01, Vol.39 (7-8), p.1476-1482

2007

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Mdm4: don't judge an isoform by its mRNA levels

Aging (Albany, NY.), 2015-10, Vol.7 (10), p.744-745

2015

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Cancer Three birds with one stone

Nature (London), 2009-07, Vol.460 (7254), p.466-467

2009

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Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4

Cell death and differentiation, 2006-06, Vol.13 (6), p.927-934

2006

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Three birds with one stone

Nature (London), 2009-07, Vol.460 (7254), p.466-467

2009

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Three birds with one stone: the core domain of the p53 protein has been found to affect microRNA processing--its third known antitumour activity. Most cancerous p53 mutations affect this domain and may abolish all tumour-suppressor functions

Nature (London), 2009-07, Vol.460 (7254), p.466

2009

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Replication Initiation In Mammalian Cells: Changing Preferences

Cell cycle (Georgetown, Tex.), 2004-01, Vol.3 (1), p.18-20

2004

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Dangerous liaisons: p53, dyskeratosis congenita and Fanconi anemia

M.S. Médecine sciences, 2017-01, Vol.33 (1), p.95

2017

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A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network

Cancer cell, 2006-04, Vol.9 (4), p.273-285

2006

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Mdm4 loss in mice expressing a p53 hypomorph alters tumor spectrum without improving survival

Oncogene, 2014-03, Vol.33 (10), p.1336-1339

2014

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Germline mutation of MDM4 , a major p53 regulator, in a familial syndrome of defective telomere maintenance

Science advances, 2020-04, Vol.6 (15), p.eaay3511

2020

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Mechanisms Generating Cancer Genome Complexity: Back to the Future

The Guardian of the Genome Revisited: p53 Downregulates Genes Required for Telomere Maintenance, DNA Repair, and Centromere Structure

Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

p53 in the Molecular Circuitry of Bone Marrow Failure Syndromes

A systematic approach identifies p53-DREAM pathway target genes associated with blood or brain abnormalities

p53 downregulates the Fanconi anaemia DNA repair pathway

Targeting MDM4 Splicing in Cancers

Essential role for centromeric factors following p53 loss and oncogenic transformation

Mutant Mice Lacking the p53 C-Terminal Domain Model Telomere Syndromes

The C-Terminal Lysines Fine-Tune P53 Stress Responses in a Mouse Model but Are Not Required for Stability Control or Transactivation

p53: A two-faced regulator of telomere metabolism? (comment on DOI 10.1002/bies.201600078)

Fuzzy tandem repeats containing p53 response elements may define species-specific p53 target genes

Expression of Fragile Sites Triggers Intrachromosomal Mammalian Gene Amplification and Sets Boundaries to Early Amplicons

Mouse Mutants Reveal that Putative Protein Interaction Sites in the p53 Proline-Rich Domain Are Dispensable for Tumor Suppression

MDM2 and MDM4: p53 regulators as targets in anticancer therapy

Mdm4: don't judge an isoform by its mRNA levels

Cancer Three birds with one stone

Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4

Three birds with one stone

Three birds with one stone: the core domain of the p53 protein has been found to affect microRNA processing--its third known antitumour activity. Most cancerous p53 mutations affect this domain and may abolish all tumour-suppressor functions

Replication Initiation In Mammalian Cells: Changing Preferences

Dangerous liaisons: p53, dyskeratosis congenita and Fanconi anemia

A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network

Mdm4 loss in mice expressing a p53 hypomorph alters tumor spectrum without improving survival

Germline mutation of MDM4 , a major p53 regulator, in a familial syndrome of defective telomere maintenance

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