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The Solid Mechanics of Cancer and Strategies for Improved Therapy

Journal of biomechanical engineering, 2017-02, Vol.139 (2)

Stylianopoulos, Triantafyllos

2017

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EPR-effect: utilizing size-dependent nanoparticle delivery to solid tumors

Therapeutic delivery, 2013-04, Vol.4 (4), p.421

Stylianopoulos, Triantafyllos

2013

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Cell Adhesion and Matrix Stiffness: Coordinating Cancer Cell Invasion and Metastasis

Frontiers in oncology, 2018-05, Vol.8, p.145-145

2018

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Defining the Role of Solid Stress and Matrix Stiffness in Cancer Cell Proliferation and Metastasis

Frontiers in oncology, 2018-03, Vol.8, p.55-55

2018

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Combining two strategies to improve perfusion and drug delivery in solid tumors

Proceedings of the National Academy of Sciences - PNAS, 2013-11, Vol.110 (46), p.18632-18637

2013

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Accumulation of mechanical forces in tumors is related to hyaluronan content and tissue stiffness

PloS one, 2018-03, Vol.13 (3), p.e0193801-e0193801

2018

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Design considerations for nanotherapeutics in oncology

Nanomedicine, 2015-11, Vol.11 (8), p.1893-1907

2015

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The role of mechanical forces in tumor growth and therapy

Annual review of biomedical engineering, 2014-07, Vol.16 (1), p.321-346

2014

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Solid Stress Facilitates Fibroblasts Activation to Promote Pancreatic Cancer Cell Migration

Annals of biomedical engineering, 2018-05, Vol.46 (5), p.657-669

2018

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Role of vascular normalization in benefit from metronomic chemotherapy

Proceedings of the National Academy of Sciences - PNAS, 2017-02, Vol.114 (8), p.1994-1999

2017

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Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside

Trends in cancer, 2018-04, Vol.4 (4), p.292

2018

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The Role of Tumor Microenvironment in Cancer Metastasis: Molecular Mechanisms and Therapeutic Opportunities

Cancers, 2021-04, Vol.13 (9), p.2053

2021

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Solid stress-induced migration is mediated by GDF15 through Akt pathway activation in pancreatic cancer cells

Scientific reports, 2019-01, Vol.9 (1), p.978, Article 978

2019

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Combining microenvironment normalization strategies to improve cancer immunotherapy

Proceedings of the National Academy of Sciences - PNAS, 2020-02, Vol.117 (7), p.3728-3737

2020

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Coevolution of Solid Stress and Interstitial Fluid Pressure in Tumors During Progression: Implications for Vascular Collapse

Cancer research (Chicago, Ill.), 2013-07, Vol.73 (13), p.3833-3841

2013

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Hyaluronan-Derived Swelling of Solid Tumors, the Contribution of Collagen and Cancer Cells, and Implications for Cancer Therapy

Neoplasia (New York, N.Y.), 2016-12, Vol.18 (12), p.732-741

2016

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Multistage nanoparticle delivery system for deep penetration into tumor tissue

Proceedings of the National Academy of Sciences - PNAS, 2011-02, Vol.108 (6), p.2426-2431

2011

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Mathematical modeling of intratumoral immunotherapy yields strategies to improve the treatment outcomes

PLoS computational biology, 2023-12, Vol.19 (12), p.e1011740-e1011740

2023

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Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma

Proceedings of the National Academy of Sciences - PNAS, 2019-02, Vol.116 (6), p.2210-2219

2019

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Delivery of Molecular and Nanoscale Medicine to Tumors: Transport Barriers and Strategies

Annual review of chemical and biomolecular engineering, 2011-07, Vol.2 (1), p.281-298

2011

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ILK silencing inhibits migration and invasion of more invasive glioblastoma cells by downregulating ROCK1 and Fascin-1

Molecular and cellular biochemistry, 2020-08, Vol.471 (1-2), p.143-153

2020

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Comparing machine learning algorithms for predicting ICU admission and mortality in COVID-19

NPJ digital medicine, 2021-05, Vol.4 (1), p.87-87, Article 87

2021

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Decompressive craniectomy of post-traumatic brain injury: an in silico modelling approach for intracranial hypertension management

Scientific reports, 2020-10, Vol.10 (1), p.18673-18673, Article 18673

2020

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Toward innovative approaches for exploring the mechanically regulated tumor-immune microenvironment

APL Bioengineering, 2024-03, Vol.8 (1), p.011501-011501-18

2024

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Sonic-hedgehog pathway inhibition normalizes desmoplastic tumor microenvironment to improve chemo- and nanotherapy

Journal of controlled release, 2017-09, Vol.261, p.105-112

2017

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The Solid Mechanics of Cancer and Strategies for Improved Therapy

EPR-effect: utilizing size-dependent nanoparticle delivery to solid tumors

Cell Adhesion and Matrix Stiffness: Coordinating Cancer Cell Invasion and Metastasis

Defining the Role of Solid Stress and Matrix Stiffness in Cancer Cell Proliferation and Metastasis

Combining two strategies to improve perfusion and drug delivery in solid tumors

Accumulation of mechanical forces in tumors is related to hyaluronan content and tissue stiffness

Design considerations for nanotherapeutics in oncology

The role of mechanical forces in tumor growth and therapy

Solid Stress Facilitates Fibroblasts Activation to Promote Pancreatic Cancer Cell Migration

Role of vascular normalization in benefit from metronomic chemotherapy

Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside

The Role of Tumor Microenvironment in Cancer Metastasis: Molecular Mechanisms and Therapeutic Opportunities

Solid stress-induced migration is mediated by GDF15 through Akt pathway activation in pancreatic cancer cells

Combining microenvironment normalization strategies to improve cancer immunotherapy

Coevolution of Solid Stress and Interstitial Fluid Pressure in Tumors During Progression: Implications for Vascular Collapse

Hyaluronan-Derived Swelling of Solid Tumors, the Contribution of Collagen and Cancer Cells, and Implications for Cancer Therapy

Multistage nanoparticle delivery system for deep penetration into tumor tissue

Mathematical modeling of intratumoral immunotherapy yields strategies to improve the treatment outcomes

Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma

Delivery of Molecular and Nanoscale Medicine to Tumors: Transport Barriers and Strategies

ILK silencing inhibits migration and invasion of more invasive glioblastoma cells by downregulating ROCK1 and Fascin-1

Comparing machine learning algorithms for predicting ICU admission and mortality in COVID-19

Decompressive craniectomy of post-traumatic brain injury: an in silico modelling approach for intracranial hypertension management

Toward innovative approaches for exploring the mechanically regulated tumor-immune microenvironment

Sonic-hedgehog pathway inhibition normalizes desmoplastic tumor microenvironment to improve chemo- and nanotherapy

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