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Activation of the epithelial sodium channel (ENaC) by serine proteases

Annual review of physiology, 2009-01, Vol.71 (1), p.361-379

2009

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Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways

Proceedings of the National Academy of Sciences - PNAS, 2013-10, Vol.110 (40), p.15973-15978

2013

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Inhibition of Protease-Epithelial Sodium Channel Signaling Improves Mucociliary Function in Cystic Fibrosis Airways

American journal of respiratory and critical care medicine, 2016-09, Vol.194 (6), p.701-710

2016

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SPLUNC1 Regulates Airway Surface Liquid Volume by Protecting ENaC from Proteolytic Cleavage

Proceedings of the National Academy of Sciences - PNAS, 2009-07, Vol.106 (27), p.11412-11417

2009

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Neutrophil elastase activates near-silent epithelial Na+ channels and increases airway epithelial Na+ transport

American journal of physiology. Lung cellular and molecular physiology, 2005-05, Vol.288 (5), p.L813-L819

2005

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Mapping allosteric linkage to channel gating by extracellular domains in the human epithelial sodium channel

The Journal of biological chemistry, 2018-03, Vol.293 (10), p.3675-3684

2018

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Cav3.2 calcium channel interactions with the epithelial sodium channel ENaC

Molecular brain, 2019-02, Vol.12 (1), p.12-12, Article 12

2019

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Nonantibiotic macrolides prevent human neutrophil elastase-induced mucus stasis and airway surface liquid volume depletion

American journal of physiology. Lung cellular and molecular physiology, 2013-06, Vol.304 (11), p.L746-L756

2013

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Regional differences in rat conjunctival ion transport activities

American Journal of Physiology: Cell Physiology, 2012-10, Vol.303 (7), p.C767-C780

2012

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A Novel Neutrophil Elastase Inhibitor Prevents Elastase Activation and Surface Cleavage of the Epithelial Sodium Channel Expressed in Xenopus laevis Oocytes

The Journal of biological chemistry, 2007-01, Vol.282 (1), p.58-64

2007

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Status of fluid and electrolyte absorption in cystic fibrosis

Cold Spring Harbor perspectives in medicine, 2013-01, Vol.3 (1), p.a009555-a009555

2013

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Phosphodiesterase 4D Forms a cAMP Diffusion Barrier at the Apical Membrane of the Airway Epithelium

The Journal of biological chemistry, 2005-03, Vol.280 (9), p.7997-8003

2005

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CFTR as a cAMP-Dependent Regulator of Sodium Channels

Science (American Association for the Advancement of Science), 1995-08, Vol.269 (5225), p.847-850

1995

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SPLUNC1 expression reduces surface levels of the epithelial sodium channel (ENaC) in Xenopus laevis oocytes

Channels (Austin, Tex.), 2010-07, Vol.4 (4), p.255-259

2010

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The Cystic Fibrosis Transmembrane Conductance Regulator Impedes Proteolytic Stimulation of the Epithelial Na+ Channel

The Journal of biological chemistry, 2010-10, Vol.285 (42), p.32227-32232

2010

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The Cystic Fibrosis Transmembrane Conductance Regulator Is Regulated by a Direct Interaction with the Protein Phosphatase 2A

The Journal of biological chemistry, 2005-12, Vol.280 (50), p.41512-41520

2005

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Cathepsin B contributes to Na+ hyperabsorption in cystic fibrosis airway epithelial cultures

The Journal of physiology, 2014-12, Vol.592 (23), p.5251-5268

2014

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The N terminus of α-ENaC mediates ENaC cleavage and activation by furin

The Journal of general physiology, 2018-08, Vol.150 (8), p.1179-1187

2018

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Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures

American journal of physiology. Lung cellular and molecular physiology, 2013-12, Vol.305 (12), p.L990-L1001

2013

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Regulation of the epithelial Na+ channel and airway surface liquid volume by serine proteases

Pflügers Archiv, 2010-06, Vol.460 (1), p.1-17

2010

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Activation of the epithelial sodium channel by the metalloprotease meprin β subunit

Channels (Austin, Tex.), 2011-01, Vol.5 (1), p.14-22

2011

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Gain-of-Function Mutation W493R in the Epithelial Sodium Channel Allosterically Reconfigures Intersubunit Coupling

The Journal of biological chemistry, 2016-02, Vol.291 (8), p.3682-3692

2016

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Serine protease activation of near-silent epithelial Na+ channels

American Journal of Physiology: Cell Physiology, 2004-01, Vol.286 (1), p.C190-C194

2004

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Preferential Assembly of Epithelial Sodium Channel (ENaC) Subunits in Xenopus Oocytes: ROLE OF FURIN-MEDIATED ENDOGENOUS PROTEOLYSIS

The Journal of biological chemistry, 2008-03, Vol.283 (12), p.7455-7463

2008

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The N-terminal Domain Allosterically Regulates Cleavage and Activation of the Epithelial Sodium Channel

The Journal of biological chemistry, 2014-08, Vol.289 (33), p.23029-23042

2014

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Activation of the epithelial sodium channel (ENaC) by serine proteases

Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways

Inhibition of Protease-Epithelial Sodium Channel Signaling Improves Mucociliary Function in Cystic Fibrosis Airways

SPLUNC1 Regulates Airway Surface Liquid Volume by Protecting ENaC from Proteolytic Cleavage

Neutrophil elastase activates near-silent epithelial Na+ channels and increases airway epithelial Na+ transport

Mapping allosteric linkage to channel gating by extracellular domains in the human epithelial sodium channel

Cav3.2 calcium channel interactions with the epithelial sodium channel ENaC

Nonantibiotic macrolides prevent human neutrophil elastase-induced mucus stasis and airway surface liquid volume depletion

Regional differences in rat conjunctival ion transport activities

A Novel Neutrophil Elastase Inhibitor Prevents Elastase Activation and Surface Cleavage of the Epithelial Sodium Channel Expressed in Xenopus laevis Oocytes

Status of fluid and electrolyte absorption in cystic fibrosis

Phosphodiesterase 4D Forms a cAMP Diffusion Barrier at the Apical Membrane of the Airway Epithelium

CFTR as a cAMP-Dependent Regulator of Sodium Channels

SPLUNC1 expression reduces surface levels of the epithelial sodium channel (ENaC) in Xenopus laevis oocytes

The Cystic Fibrosis Transmembrane Conductance Regulator Impedes Proteolytic Stimulation of the Epithelial Na+ Channel

The Cystic Fibrosis Transmembrane Conductance Regulator Is Regulated by a Direct Interaction with the Protein Phosphatase 2A

Cathepsin B contributes to Na+ hyperabsorption in cystic fibrosis airway epithelial cultures

The N terminus of α-ENaC mediates ENaC cleavage and activation by furin

Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures

Regulation of the epithelial Na+ channel and airway surface liquid volume by serine proteases

Activation of the epithelial sodium channel by the metalloprotease meprin β subunit

Gain-of-Function Mutation W493R in the Epithelial Sodium Channel Allosterically Reconfigures Intersubunit Coupling

Serine protease activation of near-silent epithelial Na+ channels

Preferential Assembly of Epithelial Sodium Channel (ENaC) Subunits in Xenopus Oocytes: ROLE OF FURIN-MEDIATED ENDOGENOUS PROTEOLYSIS

The N-terminal Domain Allosterically Regulates Cleavage and Activation of the Epithelial Sodium Channel

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