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Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design

Annual review of biochemistry, 2018-06, Vol.87, p.451

2018

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Revisiting the structures of several antibiotics bound to the bacterial ribosome

Proceedings of the National Academy of Sciences - PNAS, 2010-10, Vol.107 (40), p.17158-17163

2010

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Polyspecific pyrrolysyl-tRNA synthetases from directed evolution

Proceedings of the National Academy of Sciences - PNAS, 2014-11, Vol.111 (47), p.16724-16729

2014

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Structural Basis for the Rescue of Stalled Ribosomes: Structure of YaeJ Bound to the Ribosome

Science (American Association for the Advancement of Science), 2012-03, Vol.335 (6074), p.1370-1372

2012

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Crystal structure of elongation factor 4 bound to a clockwise ratcheted ribosome

Science (American Association for the Advancement of Science), 2014-08, Vol.345 (6197), p.684-687

2014

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Structure of apo-CAP reveals that large conformational changes are necessary for DNA binding

Proceedings of the National Academy of Sciences - PNAS, 2009-09, Vol.106 (39), p.16604-16609

2009

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The Structural Basis of Ribosome Activity in Peptide Bond Synthesis

Science (American Association for the Advancement of Science), 2000-08, Vol.289 (5481), p.920-930

2000

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Structure of pyrrolysyl-tRNA synthetase, an archaeal enzyme for genetic code innovation

Proceedings of the National Academy of Sciences - PNAS, 2007-07, Vol.104 (27), p.11268-11273

2007

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Structure of a Transcribing T7 RNA Polymerase in Transition from Initiation to Elongation

Science (American Association for the Advancement of Science), 2008-10, Vol.322 (5901), p.553-557

2008

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Structural Basis for the Transition from Initiation to Elongation Transcription in T7 RNA Polymerase

Science (American Association for the Advancement of Science), 2002-11, Vol.298 (5597), p.1387-1395

2002

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RNA, the first macromolecular catalyst: the ribosome is a ribozyme

Trends in biochemical sciences (Amsterdam. Regular ed.), 2003-08, Vol.28 (8), p.411-418

2003

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Structural Insights into Peptide Bond Formation

Proceedings of the National Academy of Sciences - PNAS, 2002-09, Vol.99 (18), p.11670-11675

2002

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Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation

iScience, 2020-09, Vol.23 (9), p.101445-101445, Article 101445

2020

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Formation of the First Peptide Bond: The Structure of EF-P Bound to the 70S Ribosome

Science (American Association for the Advancement of Science), 2009-08, Vol.325 (5943), p.966-970

2009

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Structure of Hexameric DnaB Helicase and Its Complex with a Domain of DnaG Primase

Science (American Association for the Advancement of Science), 2007-10, Vol.318 (5849), p.459-463

2007

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A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits

Nature structural & molecular biology, 2002-03, Vol.9 (3), p.225-230

2002

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Crystal structure of the DENR-MCT-1 complex revealed zinc-binding site essential for heterodimer formation

Proceedings of the National Academy of Sciences - PNAS, 2019-01, Vol.116 (2), p.528-533

2019

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Cross-crystal averaging reveals that the structure of the peptidyl-transferase center is the same in the 70S ribosome and the 50S subunit

Proceedings of the National Academy of Sciences - PNAS, 2008-01, Vol.105 (2), p.500-505

2008

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On the structural basis of peptide-bond formation and antibiotic resistance from atomic structures of the large ribosomal subunit

FEBS letters, 2005-02, Vol.579 (4), p.955-958

Steitz, Thomas A.

2005

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Visualizing polynucleotide polymerase machines at work

The EMBO journal, 2006-08, Vol.25 (15), p.3458-3468

Steitz, Thomas A

2006

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Structural Insight into Nascent Polypeptide Chain-Mediated Translational Stalling

Science (American Association for the Advancement of Science), 2009-12, Vol.326 (5958), p.1412-1415

2009

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DNA polymerases: structural diversity and common mechanisms

The Journal of biological chemistry, 1999-06, Vol.274 (25), p.17395-17398

Steitz, T A

1999

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Structure of HIV-1 Reverse Transcriptase Bound to an Inhibitor Active against Mutant Reverse Transcriptases Resistant to Other Nonnucleoside Inhibitors

Proceedings of the National Academy of Sciences - PNAS, 2004-07, Vol.101 (29), p.10548-10553

2004

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Crystal Structure of a CAP-DNA Complex: The DNA is Bent by 90

Science (American Association for the Advancement of Science), 1991-08, Vol.253 (5023), p.1001-1007

1991

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Structure of the recA protein-ADP complex

Nature (London), 1992-01, Vol.355 (6358), p.374-376

1992

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Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design

Revisiting the structures of several antibiotics bound to the bacterial ribosome

Polyspecific pyrrolysyl-tRNA synthetases from directed evolution

Structural Basis for the Rescue of Stalled Ribosomes: Structure of YaeJ Bound to the Ribosome

Crystal structure of elongation factor 4 bound to a clockwise ratcheted ribosome

Structure of apo-CAP reveals that large conformational changes are necessary for DNA binding

The Structural Basis of Ribosome Activity in Peptide Bond Synthesis

Structure of pyrrolysyl-tRNA synthetase, an archaeal enzyme for genetic code innovation

Structure of a Transcribing T7 RNA Polymerase in Transition from Initiation to Elongation

Structural Basis for the Transition from Initiation to Elongation Transcription in T7 RNA Polymerase

RNA, the first macromolecular catalyst: the ribosome is a ribozyme

Structural Insights into Peptide Bond Formation

Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation

Formation of the First Peptide Bond: The Structure of EF-P Bound to the 70S Ribosome

Structure of Hexameric DnaB Helicase and Its Complex with a Domain of DnaG Primase

A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits

Crystal structure of the DENR-MCT-1 complex revealed zinc-binding site essential for heterodimer formation

Cross-crystal averaging reveals that the structure of the peptidyl-transferase center is the same in the 70S ribosome and the 50S subunit

On the structural basis of peptide-bond formation and antibiotic resistance from atomic structures of the large ribosomal subunit

Visualizing polynucleotide polymerase machines at work

Structural Insight into Nascent Polypeptide Chain-Mediated Translational Stalling

DNA polymerases: structural diversity and common mechanisms

Structure of HIV-1 Reverse Transcriptase Bound to an Inhibitor Active against Mutant Reverse Transcriptases Resistant to Other Nonnucleoside Inhibitors

Crystal Structure of a CAP-DNA Complex: The DNA is Bent by 90

Structure of the recA protein-ADP complex

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