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Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

Biochemical journal, 2008-01, Vol.409 (2), p.581-589

2008

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Inhibition of Human Chk1 Causes Increased Initiation of DNA Replication, Phosphorylation of ATR Targets, and DNA Breakage

Molecular and Cellular Biology, 2005-05, Vol.25 (9), p.3553-3562

2005

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Expression patterns of nicotinamide phosphoribosyltransferase and nicotinic acid phosphoribosyltransferase in human malignant lymphomas

APMIS : acta pathologica, microbiologica et immunologica Scandinavica, 2011-04, Vol.119 (4-5), p.296-303

2011

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Anticancer agent CHS-828 inhibits cellular synthesis of NAD

Biochemical and biophysical research communications, 2008-03, Vol.367 (4), p.799-804

2008

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Quantitative Proteomic Analysis of Post-translational Modifications of Human Histones

Molecular & cellular proteomics, 2006-07, Vol.5 (7), p.1314-1325

2006

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Evaluation of the topoisomerase II-inactive bisdioxopiperazine ICRF-161 as a protectant against doxorubicin-induced cardiomyopathy

Toxicology (Amsterdam), 2009-01, Vol.255 (1), p.72-79

2009

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Activity of PXD101, a histone deacetylase inhibitor, in preclinical ovarian cancer studies

Molecular cancer therapeutics, 2006-08, Vol.5 (8), p.2086-2095

2006

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Imaging of treatment response to the combination of carboplatin and paclitaxel in human ovarian cancer xenograft tumors in mice using FDG and FLT PET

PloS one, 2013-12, Vol.8 (12), p.e85126-e85126

2013

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Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase

BMC cancer, 2010-12, Vol.10 (1), p.677-677, Article 677

2010

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Synthesis and Antitumor Effect in Vitro and in Vivo of Substituted 1,3-Dihydroindole-2-ones

Journal of medicinal chemistry, 2010-10, Vol.53 (19), p.7140-7145

2010

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ATM Activation in Normal Human Tissues and Testicular Cancer

Cell cycle (Georgetown, Tex.), 2005-06, Vol.4 (6), p.838-845

2005

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[18F]FLT and [18F]FDG PET for non-invasive treatment monitoring of the nicotinamide phosphoribosyltransferase inhibitor APO866 in human xenografts

PloS one, 2013-01, Vol.8 (1), p.e53410

2013

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Retinoblastoma pathway defects show differential ability to activate the constitutive DNA damage response in human tumorigenesis

Cancer research (Chicago, Ill.), 2006-11, Vol.66 (21), p.10258-10263

2006

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Early detection of response to experimental chemotherapeutic Top216 with [18F]FLT and [18F]FDG PET in human ovary cancer xenografts in mice

PloS one, 2010-09, Vol.5 (9), p.e12965

2010

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Human Xip1 (C2orf13) Is a Novel Regulator of Cellular Responses to DNA Strand Breaks

The Journal of biological chemistry, 2007-07, Vol.282 (27), p.19638-19643

2007

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MMP-9 Is Differentially Expressed in Primary Human Colorectal Adenocarcinomas and Their Metastases

Molecular cancer research, 2006-05, Vol.4 (5), p.293-302

2006

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Differential effects of class I isoform histone deacetylase depletion and enzymatic inhibition by belinostat or valproic acid in HeLa cells

Molecular cancer, 2008-09, Vol.7 (1), p.70-70

2008

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[18F]FLT PET for non-invasive assessment of tumor sensitivity to chemotherapy: studies with experimental chemotherapy TP202377 in human cancer xenografts in mice

PloS one, 2012-11, Vol.7 (11), p.e50618

2012

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The histone deacetylase inhibitor PXD101 synergises with 5-fluorouracil to inhibit colon cancer cell growth in vitro and in vivo

Cancer chemotherapy and pharmacology, 2007-07, Vol.60 (2), p.275-283

2007

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Treatment of Anthracycline Extravasation with Dexrazoxane

Clinical cancer research, 2000-09, Vol.6 (9), p.3680-3686

2000

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Dexrazoxane Protects against Myelosuppression from the DNA Cleavage–Enhancing Drugs Etoposide and Daunorubicin but not Doxorubicin

Clinical cancer research, 2005-05, Vol.11 (10), p.3915-3924

2005

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Up-Regulation of ALG-2 in Hepatomas and Lung Cancer Tissue

The American journal of pathology, 2003-07, Vol.163 (1), p.81-89

2003

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A Novel Mechanism of Cell Killing by Anti-topoisomerase II Bisdioxopiperazines

The Journal of biological chemistry, 2000-01, Vol.275 (3), p.2137-2146

2000

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

Nature, 2005-04, Vol.434 (7035), p.864-870

2005

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Stability of the Topoisomerase II Closed Clamp Conformation May Influence DNA-stimulated ATP Hydrolysis

The Journal of biological chemistry, 2005-03, Vol.280 (12), p.11920-11929

2005

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Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

Inhibition of Human Chk1 Causes Increased Initiation of DNA Replication, Phosphorylation of ATR Targets, and DNA Breakage

Expression patterns of nicotinamide phosphoribosyltransferase and nicotinic acid phosphoribosyltransferase in human malignant lymphomas

Anticancer agent CHS-828 inhibits cellular synthesis of NAD

Quantitative Proteomic Analysis of Post-translational Modifications of Human Histones

Evaluation of the topoisomerase II-inactive bisdioxopiperazine ICRF-161 as a protectant against doxorubicin-induced cardiomyopathy

Activity of PXD101, a histone deacetylase inhibitor, in preclinical ovarian cancer studies

Imaging of treatment response to the combination of carboplatin and paclitaxel in human ovarian cancer xenograft tumors in mice using FDG and FLT PET

Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase

Synthesis and Antitumor Effect in Vitro and in Vivo of Substituted 1,3-Dihydroindole-2-ones

ATM Activation in Normal Human Tissues and Testicular Cancer

[18F]FLT and [18F]FDG PET for non-invasive treatment monitoring of the nicotinamide phosphoribosyltransferase inhibitor APO866 in human xenografts

Retinoblastoma pathway defects show differential ability to activate the constitutive DNA damage response in human tumorigenesis

Early detection of response to experimental chemotherapeutic Top216 with [18F]FLT and [18F]FDG PET in human ovary cancer xenografts in mice

Human Xip1 (C2orf13) Is a Novel Regulator of Cellular Responses to DNA Strand Breaks

MMP-9 Is Differentially Expressed in Primary Human Colorectal Adenocarcinomas and Their Metastases

Differential effects of class I isoform histone deacetylase depletion and enzymatic inhibition by belinostat or valproic acid in HeLa cells

[18F]FLT PET for non-invasive assessment of tumor sensitivity to chemotherapy: studies with experimental chemotherapy TP202377 in human cancer xenografts in mice

The histone deacetylase inhibitor PXD101 synergises with 5-fluorouracil to inhibit colon cancer cell growth in vitro and in vivo

Treatment of Anthracycline Extravasation with Dexrazoxane

Dexrazoxane Protects against Myelosuppression from the DNA Cleavage–Enhancing Drugs Etoposide and Daunorubicin but not Doxorubicin

Up-Regulation of ALG-2 in Hepatomas and Lung Cancer Tissue

A Novel Mechanism of Cell Killing by Anti-topoisomerase II Bisdioxopiperazines

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

Stability of the Topoisomerase II Closed Clamp Conformation May Influence DNA-stimulated ATP Hydrolysis

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