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First administration of the Fc-attenuated anti-β amyloid antibody GSK933776 to patients with mild Alzheimer's disease: a randomized, placebo-controlled study

PloS one, 2015, Vol.10 (3), p.e0098153-e0098153

2015

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Challenges and opportunities for in vivo PROTAC delivery

Future medicinal chemistry, 2022-01, Vol.14 (3), p.119

2022

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First Administration of the Fc-Attenuated Anti- beta Amyloid Antibody GSK933776 to Patients with Mild Alzheimer's Disease: A Randomized, Placebo-Controlled Study: e0098153

PloS one, 2015-03, Vol.10 (3)

2015

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Discovery and Characterisation of Highly Cooperative FAK‐Degrading PROTACs

Angewandte Chemie (International ed.), 2021-10, Vol.60 (43), p.23327-23334

International ed. in English, 2021

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Pharmacokinetic and pharmacodynamic profiling of a P2X7 receptor allosteric modulator GSK1482160 in healthy human subjects

British journal of clinical pharmacology, 2013-01, Vol.75 (1), p.197-207

2013

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Metal dependence and branched RNA cocrystal structures of the RNA lariat debranching enzyme Dbr1

Proceedings of the National Academy of Sciences - PNAS, 2016-12, Vol.113 (51), p.14727-14732

2016

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Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2

Communications biology, 2020-03, Vol.3 (1), p.140, Article 140

2020

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Ultrasound Q&A Review for the Boards

Dawkins, Adrian

1, 2019

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Venous Thromboembolism in Critically Ill Medical Patients Receiving Chemoprophylaxis: A Focus on Obesity and Other Risk Factors

Clinical and applied thrombosis/hemostasis, 2016-04, Vol.22 (3), p.265-273

2016

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Rapid bioavailability and disposition protocol: A novel higher throughput approach to assess pharmacokinetics and steady-state tissue disstribution using fewer animals

Drug metabolism and pharmacokinetics, 2017-01, Vol.32 (1), p.S69-S69

2017

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Discovery and Characterisation of Highly Cooperative FAK‐Degrading PROTACs

Angewandte Chemie, 2021-10, Vol.133 (43), p.23515-23522

2021

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Benzodiazepine binding site occupancy by the novel GABAA receptor subtype-selective drug 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in rats, primates, and humans

The Journal of pharmacology and experimental therapeutics, 2010-01, Vol.332 (1), p.17

2010

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Rodent pharmacokinetics and receptor occupancy of the GABAA receptor subtype selective benzodiazepine site ligand L-838417

Biopharmaceutics & drug disposition, 2005-01, Vol.26 (1), p.13-20

2005

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A Model for Idiopathic Intracranial Hypertension and Associated Pathological ICP Wave-Forms

IEEE transactions on biomedical engineering, 2008-02, Vol.55 (2), p.388-398

2008

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A modeling study of idiopathic intracranial hypertension: etiology and diagnosis

Neurological research (New York), 2007-12, Vol.29 (8), p.777-786

2007

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A whole-body mathematical model for intracranial pressure dynamics

Journal of mathematical biology, 2003-04, Vol.46 (4), p.347-383

2003

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Idiopathic intracranial hypertension and transverse sinus stenosis: a modelling study

Mathematical medicine and biology, 2007-03, Vol.24 (1), p.85-109

2007

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An Evaluation of a Low-Density DNA Microarray Using Cytochrome P450 Inducers

Chemical research in toxicology, 2003-09, Vol.16 (9), p.1070-1077

2003

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Targeted protein degradation in vivo with Proteolysis Targeting Chimeras: Current status and future considerations

Drug discovery today. Technologies, 2019-04, Vol.31, p.69-80

2019

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Optimization of a Series of RIPK2 PROTACs

Journal of medicinal chemistry, 2021-09, Vol.64 (17), p.12978-13003

2021

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Contribution of specific binding to the central benzodiazepine site to the brain concentrations of two novel benzodiazepine site ligands

Biopharmaceutics & drug disposition, 2007-09, Vol.28 (6), p.275-282

2007

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Rapid Bioavailability and Disposition protocol: A novel higher throughput approach to assess pharmacokinetics and steady-state brain distribution with reduced animal usage

European journal of pharmaceutical sciences, 2018-09, Vol.122, p.13-21

2018

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GSK137, a potent small-molecule BCL6 inhibitor with in vivo activity, suppresses antibody responses in mice

The Journal of biological chemistry, 2021-08, Vol.297 (2), p.100928-100928, Article 100928

2021

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Identification and Optimization of Novel Small c‑Abl Kinase Activators Using Fragment and HTS Methodologies

Journal of medicinal chemistry, 2019-02, Vol.62 (4), p.2154-2171

2019

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First administration of the Fc-attenuated anti-β amyloid antibody GSK933776 to patients with mild Alzheimer's disease: a randomized, placebo-controlled study

Challenges and opportunities for in vivo PROTAC delivery

First Administration of the Fc-Attenuated Anti-[beta] Amyloid Antibody GSK933776 to Patients with Mild Alzheimer's Disease: A Randomized, Placebo-Controlled Study

First Administration of the Fc-Attenuated Anti- beta Amyloid Antibody GSK933776 to Patients with Mild Alzheimer's Disease: A Randomized, Placebo-Controlled Study: e0098153

Discovery and Characterisation of Highly Cooperative FAK‐Degrading PROTACs

Pharmacokinetic and pharmacodynamic profiling of a P2X7 receptor allosteric modulator GSK1482160 in healthy human subjects

Metal dependence and branched RNA cocrystal structures of the RNA lariat debranching enzyme Dbr1

Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2

Ultrasound Q&A Review for the Boards

Venous Thromboembolism in Critically Ill Medical Patients Receiving Chemoprophylaxis: A Focus on Obesity and Other Risk Factors

Rapid bioavailability and disposition protocol: A novel higher throughput approach to assess pharmacokinetics and steady-state tissue disstribution using fewer animals

Discovery and Characterisation of Highly Cooperative FAK‐Degrading PROTACs

Benzodiazepine binding site occupancy by the novel GABAA receptor subtype-selective drug 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in rats, primates, and humans

Rodent pharmacokinetics and receptor occupancy of the GABAA receptor subtype selective benzodiazepine site ligand L-838417

A Model for Idiopathic Intracranial Hypertension and Associated Pathological ICP Wave-Forms

A modeling study of idiopathic intracranial hypertension: etiology and diagnosis

A whole-body mathematical model for intracranial pressure dynamics

Idiopathic intracranial hypertension and transverse sinus stenosis: a modelling study

An Evaluation of a Low-Density DNA Microarray Using Cytochrome P450 Inducers

Targeted protein degradation in vivo with Proteolysis Targeting Chimeras: Current status and future considerations

Optimization of a Series of RIPK2 PROTACs

Contribution of specific binding to the central benzodiazepine site to the brain concentrations of two novel benzodiazepine site ligands

Rapid Bioavailability and Disposition protocol: A novel higher throughput approach to assess pharmacokinetics and steady-state brain distribution with reduced animal usage

GSK137, a potent small-molecule BCL6 inhibitor with in vivo activity, suppresses antibody responses in mice

Identification and Optimization of Novel Small c‑Abl Kinase Activators Using Fragment and HTS Methodologies

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