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Pharmacological Inhibition of MALT1 Protease Leads to a Progressive IPEX-Like Pathology

Frontiers in immunology, 2020-04, Vol.11, p.745

2020

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Structural States of Hdm2 and HdmX: X‐ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes

ChemMedChem, 2019-07, Vol.14 (14), p.1305-1314

2019

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Identification of Human Kinases Involved in Hepatitis C Virus Replication by Small Interference RNA Library Screening

The Journal of biological chemistry, 2008-01, Vol.283 (1), p.29-36

2008

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Design and preparation of 2-benzamido-pyrimidines as inhibitors of IKK

Bioorganic & medicinal chemistry letters, 2006, Vol.16 (1), p.108-112

2006

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The Role of Interstitial Macrophages in Nephropathy of Type 2 Diabetic db/db Mice

The American journal of pathology, 2007-04, Vol.170 (4), p.1267-1276

2007

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A novel Pd-catalyzed cyclization reaction of ureas for the synthesis of dihydroquinazolinone p38 kinase inhibitors

Bioorganic & medicinal chemistry letters, 2004, Vol.14 (2), p.357-360

2004

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Low-molecular-weight MK2 inhibitors: a tough nut to crack

Future medicinal chemistry, 2009-10, Vol.1 (7), p.1243

2009

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Discovery of a novel class of highly potent inhibitors of the p53–MDM2 interaction by structure-based design starting from a conformational argument

Bioorganic & medicinal chemistry letters, 2016-10, Vol.26 (19), p.4837-4841

2016

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Discovery and Optimization of Novel SUCNR1 Inhibitors: Design of Zwitterionic Derivatives with a Salt Bridge for the Improvement of Oral Exposure

Journal of medicinal chemistry, 2020-09, Vol.63 (17), p.9856-9875

2020

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Pharmacological inhibition of IKKβ dampens NLRP3 inflammasome activation after priming in the human myeloid cell line THP-1

Biochemical and biophysical research communications, 2021-03, Vol.545, p.177-182

2021

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A general palladium-catalysed synthesis of aromatic and heteroaromatic thioethers

Tetrahedron, 2001-04, Vol.57 (15), p.3069-3073

2001

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Optimization of the In Vivo Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood

Journal of medicinal chemistry, 2020-12, Vol.63 (23), p.14594-14608

2020

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Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing

Journal of medicinal chemistry, 2020-12, Vol.63 (23), p.14576-14593

2020

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In vitro and in vivo characterization of a novel, highly potent p53-MDM2 inhibitor

Bioorganic & medicinal chemistry letters, 2018-11, Vol.28 (20), p.3404-3408

2018

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The T‐cell fingerprint of MALT1 paracaspase revealed by selective inhibition

Immunology and cell biology, 2018-01, Vol.96 (1), p.81-99

2018

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N-aryl-piperidine-4-carboxamides as a novel class of potent inhibitors of MALT1 proteolytic activity

Bioorganic & medicinal chemistry letters, 2018-07, Vol.28 (12), p.2153-2158

2018

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Modulating ADME Properties by Fluorination: MK2 Inhibitors with Improved Oral Exposure

ACS medicinal chemistry letters, 2018-04, Vol.9 (4), p.392-396

2018

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Abstract 1879: Pyrazolopyrimidines as novel selective allosteric MALT1 inhibitors with in vivo activity in ABC-DLBCL

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.1879-1879

2018

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Front Cover: Structural States of Hdm2 and HdmX: X‐ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes (ChemMedChem 14/2019)

ChemMedChem, 2019-07, Vol.14 (14), p.1304-1304

2019

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Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy

Bioorganic & medicinal chemistry letters, 2010-02, Vol.20 (3), p.1293-1297

2010

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Pyrrolo-pyrimidones : A novel class of MK2 inhibitors with potent cellular activity

Bioorganic & medicinal chemistry, 2008-12, Vol.18 (23), p.6142-6146

2008

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The T‐cell fingerprint of MALT 1 paracaspase revealed by selective inhibition

Immunology and cell biology, 2018-01, Vol.96 (1), p.81-99

2018

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In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part II

Bioorganic & medicinal chemistry letters, 2010-08, Vol.20 (15), p.4719-4723

2010

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Stabilizing Inactive Conformations of MALT1 as an Effective Approach to Inhibit Its Protease Activity

Advanced therapeutics, 2020-09, Vol.3 (9), p.n/a

2020

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Pharmacological Inhibition of MALT1 Protease Leads to a Progressive IPEX-Like Pathology

Structural States of Hdm2 and HdmX: X‐ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes

Identification of Human Kinases Involved in Hepatitis C Virus Replication by Small Interference RNA Library Screening

Design and preparation of 2-benzamido-pyrimidines as inhibitors of IKK

The Role of Interstitial Macrophages in Nephropathy of Type 2 Diabetic db/db Mice

A novel Pd-catalyzed cyclization reaction of ureas for the synthesis of dihydroquinazolinone p38 kinase inhibitors

Low-molecular-weight MK2 inhibitors: a tough nut to crack

Discovery of a novel class of highly potent inhibitors of the p53–MDM2 interaction by structure-based design starting from a conformational argument

Discovery and Optimization of Novel SUCNR1 Inhibitors: Design of Zwitterionic Derivatives with a Salt Bridge for the Improvement of Oral Exposure

Pharmacological inhibition of IKKβ dampens NLRP3 inflammasome activation after priming in the human myeloid cell line THP-1

A general palladium-catalysed synthesis of aromatic and heteroaromatic thioethers

Optimization of the In Vivo Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood

Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing

In vitro and in vivo characterization of a novel, highly potent p53-MDM2 inhibitor

The T‐cell fingerprint of MALT1 paracaspase revealed by selective inhibition

N-aryl-piperidine-4-carboxamides as a novel class of potent inhibitors of MALT1 proteolytic activity

Modulating ADME Properties by Fluorination: MK2 Inhibitors with Improved Oral Exposure

Requirement of Mucosa‐Associated Lymphoid Tissue Lymphoma Translocation Protein 1 Protease Activity for Fcγ Receptor–Induced Arthritis, but Not Fcγ Receptor–Mediated Platelet Elimination, in Mice

Abstract 1879: Pyrazolopyrimidines as novel selective allosteric MALT1 inhibitors with in vivo activity in ABC-DLBCL

Front Cover: Structural States of Hdm2 and HdmX: X‐ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes (ChemMedChem 14/2019)

Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy

Pyrrolo-pyrimidones : A novel class of MK2 inhibitors with potent cellular activity

The T‐cell fingerprint of MALT 1 paracaspase revealed by selective inhibition

In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part II

Stabilizing Inactive Conformations of MALT1 as an Effective Approach to Inhibit Its Protease Activity

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