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Evaluation of a 5-HT2B receptor agonist in a murine model of amyotrophic lateral sclerosis

Scientific reports, 2021-12, Vol.11 (1), p.23582-23582, Article 23582

2021

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EGFR signaling and pharmacology in oncology revealed with innovative BRET-based biosensors

Communications biology, 2024-03, Vol.7 (1), p.250-250

2024

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Methylation of imidazoline related compounds leads to loss of α2-adrenoceptor affinity. Synthesis and biological evaluation of selective I1 imidazoline receptor ligands

Bioorganic & medicinal chemistry, 2012-08, Vol.20 (15), p.4710-4715

2012

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Abstract LB123: A high value pharmacological platform dedicated to the real time study of stimulatory immune checkpoint signaling pathways

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.LB123-LB123

2021

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Abstract LB-004: Signaling signature profiling of cancer-associated RTK mutants

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.LB-004-LB-004

2019

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Abstract LB187: EGFR signaling and pharmacology in oncology revealed with an innovative RTK biosensor technology

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.LB187-LB187

2021

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Abstract 6304: Decrypting EGFR signaling with BRET biosensors: A novel approach to study RTK mutations and the effects of inhibitors

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.6304-6304

2020

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Abstract 934: “GPCR-ome” modulation upon PD1 / PDL1 axis blockade

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.934-934

2020

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Amino-Pyrrolidine Tricarboxylic Acids Give New Insight into Group III Metabotropic Glutamate Receptor Activation Mechanism

Molecular pharmacology, 2007-03, Vol.71 (3), p.704-712

2007

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Abstract 6697: DT095895, a selective EP4 receptor antagonist with monotherapy efficacy in syngeneic mouse model(s) and best-in-class properties

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.6697-6697

2020

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Profiling the Signaling Repertoire of One Hundred Therapeutically‐Relevant Human GPCRs

The FASEB journal, 2020-04, Vol.34 (S1), p.1-1

2020

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Discovery, Structure–Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4

Journal of medicinal chemistry, 2017-10, Vol.60 (20), p.8515-8537

2017

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Use of Novel ebBRET Biosensors for Comprehensive Signaling Profiling of One Hundred Therapeutically Relevant Human GPCRs

The FASEB journal, 2021-05, Vol.35 (S1), p.n/a, Article fasebj.2021.35.S1.01694

2021

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LNP 906, the first high‐affinity photoaffinity ligand selective for I1 imidazoline receptors

British journal of pharmacology, 2004-06, Vol.142 (3), p.609-617

2004

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Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present)

Expert opinion on therapeutic patents, 2015-01, Vol.25 (1), p.69-90

2015

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Chemical Switch of a Metabotropic Glutamate Receptor 2 Silent Allosteric Modulator into Dual Metabotropic Glutamate Receptor 2/3 Negative/Positive Allosteric Modulators

Journal of medicinal chemistry, 2010-12, Vol.53 (24), p.8775-8779

2010

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Synthesis and Biological Evaluation of 2‑Aryliminopyrrolidines as Selective Ligands for I1 Imidazoline Receptors: Discovery of New Sympatho-Inhibitory Hypotensive Agents with Potential Beneficial Effects in Metabolic Syndrome

Journal of medicinal chemistry, 2015-01, Vol.58 (2), p.878-887

2015

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817 DT095895, a selective EP4 receptor antagonist with monotherapy efficacy in syngeneic mouse model(s) and best-in-class properties

Journal for immunotherapy of cancer, 2020-11, Vol.8 (Suppl 3), p.A865-A865

2020

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Synthesis and Biological Evaluation of 2-Aryliminopyrrolidines as Selective Ligands for I 1 Imidazoline Receptors: Discovery of New Sympatho-Inhibitory Hypotensive Agents with Potential Beneficial Effects in Metabolic Syndrome

Journal of medicinal chemistry, 2015-01, Vol.58 (2), p.878-887

2015

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Evaluation of a 5-HT 2B receptor agonist in a murine model of amyotrophic lateral sclerosis

Scientific reports, 2021-12, Vol.11 (1), p.23582

2021

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Technology combination to address GPCR allosteric modulator drug-discovery pitfalls

Drug discovery today. Technologies, 2013, Vol.10 (2), p.e261-e267

2013

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Abstract 2946: Depleting hCCR8 mAb Therapy #1: Characterization of a broad collection of anti-hCCR8 mAbs

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.2946-2946

2023

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Abstract 4961: Novel biased PAR2 inhibitors with best-in-class properties reduce resistance to both chemotherapy and immunotherapy in oncology models

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.4961-4961

2023

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Evaluation of a 5-HT2B receptor agonist in a murine model of amyotrophic lateral sclerosis

Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs

EGFR signaling and pharmacology in oncology revealed with innovative BRET-based biosensors

Methylation of imidazoline related compounds leads to loss of α2-adrenoceptor affinity. Synthesis and biological evaluation of selective I1 imidazoline receptor ligands

Abstract LB123: A high value pharmacological platform dedicated to the real time study of stimulatory immune checkpoint signaling pathways

Abstract LB-004: Signaling signature profiling of cancer-associated RTK mutants

Abstract LB187: EGFR signaling and pharmacology in oncology revealed with an innovative RTK biosensor technology

Abstract 6304: Decrypting EGFR signaling with BRET biosensors: A novel approach to study RTK mutations and the effects of inhibitors

Abstract 934: “GPCR-ome” modulation upon PD1 / PDL1 axis blockade

Amino-Pyrrolidine Tricarboxylic Acids Give New Insight into Group III Metabotropic Glutamate Receptor Activation Mechanism

Abstract 6697: DT095895, a selective EP4 receptor antagonist with monotherapy efficacy in syngeneic mouse model(s) and best-in-class properties

Profiling the Signaling Repertoire of One Hundred Therapeutically‐Relevant Human GPCRs

Discovery, Structure–Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4

Use of Novel ebBRET Biosensors for Comprehensive Signaling Profiling of One Hundred Therapeutically Relevant Human GPCRs

LNP 906, the first high‐affinity photoaffinity ligand selective for I1 imidazoline receptors

Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present)

Chemical Switch of a Metabotropic Glutamate Receptor 2 Silent Allosteric Modulator into Dual Metabotropic Glutamate Receptor 2/3 Negative/Positive Allosteric Modulators

Synthesis and Biological Evaluation of 2‑Aryliminopyrrolidines as Selective Ligands for I1 Imidazoline Receptors: Discovery of New Sympatho-Inhibitory Hypotensive Agents with Potential Beneficial Effects in Metabolic Syndrome

817 DT095895, a selective EP4 receptor antagonist with monotherapy efficacy in syngeneic mouse model(s) and best-in-class properties

Synthesis and Biological Evaluation of 2-Aryliminopyrrolidines as Selective Ligands for I 1 Imidazoline Receptors: Discovery of New Sympatho-Inhibitory Hypotensive Agents with Potential Beneficial Effects in Metabolic Syndrome

Effector membrane translocation biosensors reveal G protein and [beta]arrestin coupling profiles of 100 therapeutically relevant GPCRs

Evaluation of a 5-HT 2B receptor agonist in a murine model of amyotrophic lateral sclerosis

Technology combination to address GPCR allosteric modulator drug-discovery pitfalls

Abstract 2946: Depleting hCCR8 mAb Therapy #1: Characterization of a broad collection of anti-hCCR8 mAbs

Abstract 4961: Novel biased PAR2 inhibitors with best-in-class properties reduce resistance to both chemotherapy and immunotherapy in oncology models

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