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Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations

Nature reviews. Genetics, 2018-05, Vol.19 (5), p.269

2018

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Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage

PLoS genetics, 2013-09, Vol.9 (9), p.e1003794

2013

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The influence of subclonal resistance mutations on targeted cancer therapy

Nature reviews. Clinical oncology, 2016-06, Vol.13 (6), p.335-347

2016

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Detection of ultra-rare mutations by next-generation sequencing

Proceedings of the National Academy of Sciences - PNAS, 2012-09, Vol.109 (36), p.14508-14513

2012

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Next‐Generation Genotoxicology: Using Modern Sequencing Technologies to Assess Somatic Mutagenesis and Cancer Risk

Environmental and molecular mutagenesis, 2020-01, Vol.61 (1), p.135-151

2020

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Direct quantification of in vivo mutagenesis and carcinogenesis using duplex sequencing

Proceedings of the National Academy of Sciences - PNAS, 2020-12, Vol.117 (52), p.33414-33425

2020

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Mutational heterogeneity in human cancers: origin and consequences

Annual review of pathology, 2010-01, Vol.5 (1), p.51-75

2010

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Duplex sequencing identifies genomic features that determine susceptibility to benzo(a)pyrene-induced in vivo mutations

BMC genomics, 2022-07, Vol.23 (1), p.542-15, Article 542

2022

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Detecting ultralow-frequency mutations by Duplex Sequencing

Nature protocols, 2014-11, Vol.9 (11), p.2586-2606

2014

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Extensive subclonal mutational diversity in human colorectal cancer and its significance

Proceedings of the National Academy of Sciences - PNAS, 2019-12, Vol.116 (52), p.26863-26872

2019

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Precancer in ulcerative colitis: the role of the field effect and its clinical implications

Carcinogenesis (New York), 2018-01, Vol.39 (1), p.11-20

2018

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Decreased mitochondrial DNA mutagenesis in human colorectal cancer

PLoS genetics, 2012-06, Vol.8 (6), p.e1002689

2012

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Ultra-Sensitive TP53 Sequencing for Cancer Detection Reveals Progressive Clonal Selection in Normal Tissue over a Century of Human Lifespan

Cell reports (Cambridge), 2019-07, Vol.28 (1), p.132-144.e3

2019

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Optimization of DNA polymerase mutation rates during bacterial evolution

Proceedings of the National Academy of Sciences - PNAS, 2010-01, Vol.107 (3), p.1154-1159

2010

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Targeted genome fragmentation with CRISPR/Cas9 enables fast and efficient enrichment of small genomic regions and ultra-accurate sequencing with low DNA input (CRISPR-DS)

Genome research, 2018-10, Vol.28 (10), p.1589

2018

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Quantification of measurable residual disease using duplex sequencing in adults with acute myeloid leukemia

Haematologica (Roma), 2024-02, Vol.109 (2), p.401-410

2024

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Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing

Nature reviews. Drug discovery, 2023-03, Vol.22 (3), p.165-166

2023

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Duplex sequencing provides detailed characterization of mutation frequencies and spectra in the bone marrow of MutaMouse males exposed to procarbazine hydrochloride

Archives of toxicology, 2023-08, Vol.97 (8), p.2245-2259

2023

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Hypermutable DNA chronicles the evolution of human colon cancer

Proceedings of the National Academy of Sciences - PNAS, 2014-05, Vol.111 (18), p.E1889-E1898

2014

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Next Generation Sequencing Workshop at the Royal Society of Medicine (London, May 2022): how genomics is on the path to modernizing genetic toxicology

Mutagenesis, 2023-08, Vol.38 (4), p.192-200

2023

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Error-corrected duplex sequencing enables direct detection and quantification of mutations in human TK6 cells with strong inter-laboratory consistency

Mutation research. Genetic toxicology and environmental mutagenesis, 2023-07, Vol.889, p.503649-503649, Article 503649

2023

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PolyG-DS: An ultrasensitive polyguanine tract-profiling method to detect clonal expansions and trace cell lineage

Proceedings of the National Academy of Sciences - PNAS, 2021-08, Vol.118 (31), p.1

2021

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Error-corrected next generation sequencing – Promises and challenges for genotoxicity and cancer risk assessment

Mutation research. Reviews in mutation research, 2023-07, Vol.792, p.108466-108466, Article 108466

2023

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Adopting duplex sequencing technology for genetic toxicity testing: A proof-of-concept mutagenesis experiment with N-ethyl-N-nitrosourea (ENU)-exposed rats

Mutation research. Genetic toxicology and environmental mutagenesis, 2023-10, Vol.891, p.503669-503669, Article 503669

2023

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Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing DNA damage with the CometChip and mutagenesis by Duplex Sequencing

Environmental and molecular mutagenesis, 2021-06, Vol.62 (5), p.306-318

2021

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Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations

Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage

The influence of subclonal resistance mutations on targeted cancer therapy

Detection of ultra-rare mutations by next-generation sequencing

Next‐Generation Genotoxicology: Using Modern Sequencing Technologies to Assess Somatic Mutagenesis and Cancer Risk

Direct quantification of in vivo mutagenesis and carcinogenesis using duplex sequencing

Mutational heterogeneity in human cancers: origin and consequences

Duplex sequencing identifies genomic features that determine susceptibility to benzo(a)pyrene-induced in vivo mutations

Detecting ultralow-frequency mutations by Duplex Sequencing

Extensive subclonal mutational diversity in human colorectal cancer and its significance

Precancer in ulcerative colitis: the role of the field effect and its clinical implications

Decreased mitochondrial DNA mutagenesis in human colorectal cancer

Ultra-Sensitive TP53 Sequencing for Cancer Detection Reveals Progressive Clonal Selection in Normal Tissue over a Century of Human Lifespan

Optimization of DNA polymerase mutation rates during bacterial evolution

Targeted genome fragmentation with CRISPR/Cas9 enables fast and efficient enrichment of small genomic regions and ultra-accurate sequencing with low DNA input (CRISPR-DS)

Quantification of measurable residual disease using duplex sequencing in adults with acute myeloid leukemia

Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing

Duplex sequencing provides detailed characterization of mutation frequencies and spectra in the bone marrow of MutaMouse males exposed to procarbazine hydrochloride

Hypermutable DNA chronicles the evolution of human colon cancer

Next Generation Sequencing Workshop at the Royal Society of Medicine (London, May 2022): how genomics is on the path to modernizing genetic toxicology

Error-corrected duplex sequencing enables direct detection and quantification of mutations in human TK6 cells with strong inter-laboratory consistency

PolyG-DS: An ultrasensitive polyguanine tract-profiling method to detect clonal expansions and trace cell lineage

Error-corrected next generation sequencing – Promises and challenges for genotoxicity and cancer risk assessment

Adopting duplex sequencing technology for genetic toxicity testing: A proof-of-concept mutagenesis experiment with N-ethyl-N-nitrosourea (ENU)-exposed rats

Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing DNA damage with the CometChip and mutagenesis by Duplex Sequencing

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