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X-ray structure breakthroughs in the GPCR transmembrane region

Biochemical pharmacology, 2009-07, Vol.78 (1), p.11-20

2009

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Use of the X-ray structure of the β2-adrenergic receptor for drug discovery. Part 2: Identification of active compounds

Bioorganic & medicinal chemistry letters, 2008-10, Vol.18 (20), p.5391-5395

2008

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7TM X-ray structures for class C GPCRs as new drug-discovery tools. 1. mGluR5

Bioorganic & medicinal chemistry letters, 2016-01, Vol.26 (2), p.484-494

2016

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The role of experimental and computational structural approaches in 7TM drug discovery

Expert opinion on drug discovery, 2015-10, Vol.10 (10), p.1071-1084

2015

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Use of the X-ray structure of the Beta2-adrenergic receptor for drug discovery

Bioorganic & medicinal chemistry, 2008-03, Vol.18 (5), p.1598-1602

2008

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Identification and Characterization of Small‐Molecule Ras Modulators and their Impact in Cancer Drug Discovery

The FASEB journal, 2020-04, Vol.34 (S1), p.1-1

2020

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Design and biological characterization of a series of dual mechanism ERK1/2 inhibitors with a Triazolopyridinone core

Chemical biology & drug design, 2023-04, Vol.101 (4), p.837-847

2023

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Structural and Conformational Requirements for High-Affinity Binding to the SH2 Domain of Grb2

Journal of medicinal chemistry, 1999-03, Vol.42 (6), p.971-980

1999

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Exploration of structure-based drug design opportunities for mGluRs

Neuropharmacology, 2011, Vol.60 (1), p.93-101

2011

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Antagonists for Constitutively Active Mutant Estrogen Receptors: Insights into the Roles of Antiestrogen-Core and Side-Chain

ACS chemical biology, 2018-12, Vol.13 (12), p.3374-3384

2018

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Tricyclic Thiazolopyrazole Derivatives as Metabotropic Glutamate Receptor 4 Positive Allosteric Modulators

Journal of medicinal chemistry, 2011-07, Vol.54 (14), p.5070-5081

2011

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Use of the X-ray structure of the beta sub(2)-adrenergic receptor for drug discovery. Part 2: Identification of active compounds

Bioorganic & medicinal chemistry, 2008-10, Vol.18 (20), p.5391-5395

2008

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Design and Synthesis of Potent and Selective Inhibitors of Integrin VLA-4

Bioorganic & medicinal chemistry letters, 2001-11, Vol.11 (22), p.2955-2958

2001

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4-(1-Phenyl-1H-pyrazol-4-yl)quinolines as novel, selective and brain penetrant metabotropic glutamate receptor 4 positive allosteric modulators

Bioorganic & medicinal chemistry letters, 2012-05, Vol.22 (9), p.3235-3239

2012

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Use of the X-ray structure of the β 2-adrenergic receptor for drug discovery. Part 2: Identification of active compounds

Bioorganic & medicinal chemistry letters, 2008, Vol.18 (20), p.5391-5395

2008

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cis-1-Oxo-heterocyclyl-4-amido cyclohexane derivatives as NPY5 receptor antagonists

Bioorganic & medicinal chemistry letters, 2014-03, Vol.24 (6), p.1458-1461

2014

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Depletion of methionine aminopeptidase 2 does not alter cell response to fumagillin or bengamides

Cancer research (Chicago, Ill.), 2004-05, Vol.64 (9), p.2984-2987

2004

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1,4-Diazepane-2,5-diones as novel inhibitors of LFA-1

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (4), p.1217-1220

2005

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Homology Modeling of the Serotonin Transporter: Insights into the Primary Escitalopram-binding Site

ChemMedChem, 2007-06, Vol.2 (6), p.815-826

2007

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Use of the X-ray structure of the beta2-adrenergic receptor for drug discovery. Part 2: Identification of active compounds

Bioorganic & medicinal chemistry letters, 2008-10, Vol.18 (20), p.5391-5395

2008

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Development of an aequorin luminescence calcium assay for high-throughput screening using a plate reader, the LumiLux

Assay and drug development technologies, 2008-12, Vol.6 (6), p.787

2008

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1,4-Diazepane-2-ones as novel inhibitors of LFA-1

Bioorganic & medicinal chemistry letters, 2003-02, Vol.13 (3), p.499-502

2003

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Recognition of cholinergic agonists by the muscarinic receptor. 1. Acetylcholine and other agonists with the NCCOCC backbone

Journal of medicinal chemistry, 1983-06, Vol.26 (6), p.817-823

1983

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Energetics of valence isomerization in seven-membered rings. Cycloheptatriene-norcaradiene and related rearrangements

Journal of the American Chemical Society, , Vol.106 (25), p.7696-7700

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Theoretical studies of borepin and cycloheptatriene

Journal of the American Chemical Society, 1982-07, Vol.104 (14), p.3785-3788

1982

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X-ray structure breakthroughs in the GPCR transmembrane region

Use of the X-ray structure of the β2-adrenergic receptor for drug discovery. Part 2: Identification of active compounds

7TM X-ray structures for class C GPCRs as new drug-discovery tools. 1. mGluR5

The role of experimental and computational structural approaches in 7TM drug discovery

Use of the X-ray structure of the Beta2-adrenergic receptor for drug discovery

Identification and Characterization of Small‐Molecule Ras Modulators and their Impact in Cancer Drug Discovery

Design and biological characterization of a series of dual mechanism ERK1/2 inhibitors with a Triazolopyridinone core

Structural and Conformational Requirements for High-Affinity Binding to the SH2 Domain of Grb2

Exploration of structure-based drug design opportunities for mGluRs

Antagonists for Constitutively Active Mutant Estrogen Receptors: Insights into the Roles of Antiestrogen-Core and Side-Chain

Tricyclic Thiazolopyrazole Derivatives as Metabotropic Glutamate Receptor 4 Positive Allosteric Modulators

Use of the X-ray structure of the beta sub(2)-adrenergic receptor for drug discovery. Part 2: Identification of active compounds

Design and Synthesis of Potent and Selective Inhibitors of Integrin VLA-4

4-(1-Phenyl-1H-pyrazol-4-yl)quinolines as novel, selective and brain penetrant metabotropic glutamate receptor 4 positive allosteric modulators

Use of the X-ray structure of the β 2-adrenergic receptor for drug discovery. Part 2: Identification of active compounds

cis-1-Oxo-heterocyclyl-4-amido cyclohexane derivatives as NPY5 receptor antagonists

Depletion of methionine aminopeptidase 2 does not alter cell response to fumagillin or bengamides

1,4-Diazepane-2,5-diones as novel inhibitors of LFA-1

Homology Modeling of the Serotonin Transporter: Insights into the Primary Escitalopram-binding Site

Use of the X-ray structure of the beta2-adrenergic receptor for drug discovery. Part 2: Identification of active compounds

Development of an aequorin luminescence calcium assay for high-throughput screening using a plate reader, the LumiLux

1,4-Diazepane-2-ones as novel inhibitors of LFA-1

Recognition of cholinergic agonists by the muscarinic receptor. 1. Acetylcholine and other agonists with the NCCOCC backbone

Energetics of valence isomerization in seven-membered rings. Cycloheptatriene-norcaradiene and related rearrangements

Theoretical studies of borepin and cycloheptatriene

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