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Insulin Secretion Depends on Intra-islet Glucagon Signaling

Cell reports (Cambridge), 2018-10, Vol.25 (5), p.1127-1134.e2

2018

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N‐terminally and C‐terminally truncated forms of glucose‐dependent insulinotropic polypeptide are high‐affinity competitive antagonists of the human GIP receptor

British journal of pharmacology, 2016-03, Vol.173 (5), p.826-838

2016

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Protein engineering of the chemokine CCL20 prevents psoriasiform dermatitis in an IL-23–dependent murine model

Proceedings of the National Academy of Sciences - PNAS, 2017-11, Vol.114 (47), p.12460-12465

2017

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Species‐specific action of (Pro3)GIP – a full agonist at human GIP receptors, but a partial agonist and competitive antagonist at rat and mouse GIP receptors

British journal of pharmacology, 2016-01, Vol.173 (1), p.27-38

2016

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Therapeutic targeting of HCMV-encoded chemokine receptor US28: Progress and challenges

Frontiers in immunology, 2023-02, Vol.14, p.1135280-1135280

2023

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Distinct expression and ligand‐binding profiles of two constitutively active GPR17 splice variants

British journal of pharmacology, 2010-03, Vol.159 (5), p.1092-1105

2010

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Targeting the latent cytomegalovirus reservoir with an antiviral fusion toxin protein

Nature communications, 2017-02, Vol.8 (1), p.14321-14321, Article 14321

2017

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Ligand binding and micro-switches in 7TM receptor structures

Trends in pharmacological sciences (Regular ed.), 2009-05, Vol.30 (5), p.249-259

2009

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Biased and g protein-independent signaling of chemokine receptors

Frontiers in immunology, 2014, Vol.5, p.277-277

2014

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Determination of the binding mode for the cyclopentapeptide CXCR4 antagonist FC131 using a dual approach of ligand modifications and receptor mutagenesis

British journal of pharmacology, 2014-12, Vol.171 (23), p.5313-5329

2014

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Loss of Adgra3 causes obstructive azoospermia with high penetrance in male mice

The FASEB journal, 2023-02, Vol.37 (2), p.e22781-n/a

2023

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Structural basis for the constitutive activity and immunomodulatory properties of the Epstein-Barr virus-encoded G protein-coupled receptor BILF1

Immunity (Cambridge, Mass.), 2021-07, Vol.54 (7), p.1405-1416.e7

2021

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Molecular mechanism of 7TM receptor activation : A global toggle switch model

Annual review of pharmacology and toxicology, 2006-01, Vol.46 (1), p.481-519

2006

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The non-ELR CXC chemokine encoded by human cytomegalovirus UL146 genotype 5 contains a C-terminal β-hairpin and induces neutrophil migration as a selective CXCR2 agonist

PLoS pathogens, 2022-03, Vol.18 (3), p.e1010355-e1010355

2022

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GIP(3–30)NH2 is a potent competitive antagonist of the GIP receptor and effectively inhibits GIP-mediated insulin, glucagon, and somatostatin release

Biochemical pharmacology, 2017-05, Vol.131, p.78-88

2017

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Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas

Molecular metabolism (Germany), 2018-05, Vol.11, p.84-95

2018

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Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist

JCI insight, 2020-09, Vol.5 (17)

2020

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The importance of glucose‐dependent insulinotropic polypeptide receptor activation for the effects of tirzepatide

Diabetes, obesity & metabolism, 2023-11, Vol.25 (11), p.3079-3092

2023

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An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles

Nature communications, 2020-08, Vol.11 (1), p.4033-4033, Article 4033

2020

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“Glyco-sulfo barcodes” regulate chemokine receptor function

Cellular and molecular life sciences : CMLS, 2023-02, Vol.80 (2), p.55-55, Article 55

2023

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Advances in incretin-based therapeutics for obesity

Nature reviews. Endocrinology, 2024-02, Vol.20 (2), p.67-68

Rosenkilde, Mette M

2024

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Cell transformation mediated by the Epstein-Barr virus G protein-coupled receptor BILF1 is dependent on constitutive signaling

Oncogene, 2010-08, Vol.29 (31), p.4388-4398

2010

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Effects of active commuting and leisure-time exercise on fat loss in women and men with overweight and obesity: a randomized controlled trial

International Journal of Obesity, 2018-03, Vol.42 (3), p.469-478

2018

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The minor binding pocket: a major player in 7TM receptor activation

Trends in pharmacological sciences (Regular ed.), 2010-12, Vol.31 (12), p.567-574

2010

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Development of highly efficient protocols for extraction and amplification of cytomegalovirus DNA from dried blood spots for detection and genotyping of polymorphic immunomodulatory genes

PloS one, 2019-09, Vol.14 (9), p.e0222053-e0222053

2019

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Insulin Secretion Depends on Intra-islet Glucagon Signaling

N‐terminally and C‐terminally truncated forms of glucose‐dependent insulinotropic polypeptide are high‐affinity competitive antagonists of the human GIP receptor

Protein engineering of the chemokine CCL20 prevents psoriasiform dermatitis in an IL-23–dependent murine model

Species‐specific action of (Pro3)GIP – a full agonist at human GIP receptors, but a partial agonist and competitive antagonist at rat and mouse GIP receptors

Therapeutic targeting of HCMV-encoded chemokine receptor US28: Progress and challenges

Distinct expression and ligand‐binding profiles of two constitutively active GPR17 splice variants

Targeting the latent cytomegalovirus reservoir with an antiviral fusion toxin protein

Ligand binding and micro-switches in 7TM receptor structures

Biased and g protein-independent signaling of chemokine receptors

Determination of the binding mode for the cyclopentapeptide CXCR4 antagonist FC131 using a dual approach of ligand modifications and receptor mutagenesis

Loss of Adgra3 causes obstructive azoospermia with high penetrance in male mice

Structural basis for the constitutive activity and immunomodulatory properties of the Epstein-Barr virus-encoded G protein-coupled receptor BILF1

Molecular mechanism of 7TM receptor activation : A global toggle switch model

The non-ELR CXC chemokine encoded by human cytomegalovirus UL146 genotype 5 contains a C-terminal β-hairpin and induces neutrophil migration as a selective CXCR2 agonist

GIP(3–30)NH2 is a potent competitive antagonist of the GIP receptor and effectively inhibits GIP-mediated insulin, glucagon, and somatostatin release

Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas

Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist

The importance of glucose‐dependent insulinotropic polypeptide receptor activation for the effects of tirzepatide

An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles

“Glyco-sulfo barcodes” regulate chemokine receptor function

Advances in incretin-based therapeutics for obesity

Cell transformation mediated by the Epstein-Barr virus G protein-coupled receptor BILF1 is dependent on constitutive signaling

Effects of active commuting and leisure-time exercise on fat loss in women and men with overweight and obesity: a randomized controlled trial

The minor binding pocket: a major player in 7TM receptor activation

Development of highly efficient protocols for extraction and amplification of cytomegalovirus DNA from dried blood spots for detection and genotyping of polymorphic immunomodulatory genes

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