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The molecular and genetic basis of antifungal resistance in the emerging fungal pathogen Candida auris

Current opinion in microbiology, 2022-12, Vol.70, p.102208-102208, Article 102208

2022

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Editorial overview: Recent advances in antimicrobial drug discovery and resistance

Current opinion in microbiology, 2023-02, Vol.71, p.102242-102242, Article 102242

2023

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The Candida glabrata Upc2A transcription factor is a global regulator of antifungal drug resistance pathways

PLoS genetics, 2021-09, Vol.17 (9), p.e1009582-e1009582

2021

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Contribution of clinically derived mutations in ERG11 to azole resistance in Candida albicans

Antimicrobial agents and chemotherapy, 2015-01, Vol.59 (1), p.450-460

2015

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Emerging threat of triazole-resistant Aspergillus fumigatus

Journal of antimicrobial chemotherapy, 2019-04, Vol.74 (4), p.835-842

2019

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Gain-of-Function Mutations in UPC2 Are a Frequent Cause of ERG11 Upregulation in Azole-Resistant Clinical Isolates of Candida albicans

Eukaryotic Cell, 2012-10, Vol.11 (10), p.1289-1299

2012

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Mutations in TAC1B : a Novel Genetic Determinant of Clinical Fluconazole Resistance in Candida auris

mBio, 2020-05, Vol.11 (3)

2020

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Mutations in the multi-drug resistance regulator MRR1, followed by loss of heterozygosity, are the main cause of MDR1 overexpression in fluconazole-resistant Candida albicans strains

Molecular microbiology, 2008-08, Vol.69 (4), p.827-840

2008

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The transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicans

PLoS pathogens, 2007-11, Vol.3 (11), p.e164

2007

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A Review of Pneumococcal Vaccines: Current Polysaccharide Vaccine Recommendations and Future Protein Antigens

The journal of pediatric pharmacology and therapeutics, 2016-01, Vol.21 (1), p.27-35

2016

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Relative Contribution of the ABC Transporters Cdr1, Pdh1, and Snq2 to Azole Resistance in Candida glabrata

Antimicrobial agents and chemotherapy, 2018-10, Vol.62 (10)

2018

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Isavuconazole: Pharmacology, Pharmacodynamics, and Current Clinical Experience with a New Triazole Antifungal Agent

Pharmacotherapy, 2015-11, Vol.35 (11), p.1037-1051

2015

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Contribution of Clinically Derived Mutations in the Gene Encoding the Zinc Cluster Transcription Factor Mrr2 to Fluconazole Antifungal Resistance and CDR1 Expression in Candida albicans

Antimicrobial agents and chemotherapy, 2019-05, Vol.63 (5)

2019

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In Vitro Activities of the Novel Investigational Tetrazoles VT-1161 and VT-1598 Compared to the Triazole Antifungals against Azole-Resistant Strains and Clinical Isolates of Candida albicans

Antimicrobial agents and chemotherapy, 2019-06, Vol.63 (6)

2019

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A Hyperactive Form of the Zinc Cluster Transcription Factor Stb5 Causes YOR1 Overexpression and Beauvericin Resistance in Candida albicans

Antimicrobial agents and chemotherapy, 2018-12, Vol.62 (12)

2018

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Delineation of the Direct Contribution of Candida auris ERG11 Mutations to Clinical Triazole Resistance

Microbiology spectrum, 2021-12, Vol.9 (3), p.e0158521

2021

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Weather and climate resilience: effective preparedness through national meteorological and hydrological services (Directions in development: environment and sustainable development)

1, 2013

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An A643T Mutation in the Transcription Factor Upc2p Causes Constitutive ERG11 Upregulation and Increased Fluconazole Resistance in Candida albicans

Antimicrobial Agents and Chemotherapy, 2010-01, Vol.54 (1), p.353-359

2010

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hapE and hmg1 Mutations Are Drivers of cyp51A -Independent Pan-Triazole Resistance in an Aspergillus fumigatus Clinical Isolate

Microbiology spectrum, 2023-06, Vol.11 (3), p.e0518822-e0518822

2023

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Changes in the Proteome of Candida albicans in Response to Azole, Polyene, and Echinocandin Antifungal Agents

Antimicrobial Agents and Chemotherapy, 2010-05, Vol.54 (5), p.1655-1664

2010

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Regulation of Efflux Pump Expression and Drug Resistance by the Transcription Factors Mrr1, Upc2, and Cap1 in Candida albicans

Antimicrobial Agents and Chemotherapy, 2011-05, Vol.55 (5), p.2212-2223

2011

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A Systematic Screen Reveals a Diverse Collection of Medications That Induce Antifungal Resistance in Candida Species

Antimicrobial agents and chemotherapy, 2019-05, Vol.63 (5)

2019

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Characterization of the Efflux Capability and Substrate Specificity of Aspergillus fumigatus PDR5-like ABC Transporters Expressed in Saccharomyces cerevisiae

mBio, 2020-03, Vol.11 (2)

2020

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A Gain-of-Function Mutation in the Transcription Factor Upc2p Causes Upregulation of Ergosterol Biosynthesis Genes and Increased Fluconazole Resistance in a Clinical Candida albicans Isolate

Eukaryotic Cell, 2008-07, Vol.7 (7), p.1180-1190

2008

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UPC2 is universally essential for azole antifungal resistance in Candida albicans

Eukaryotic cell, 2014-07, Vol.13 (7), p.933-946

2014

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The molecular and genetic basis of antifungal resistance in the emerging fungal pathogen Candida auris

Editorial overview: Recent advances in antimicrobial drug discovery and resistance

The Candida glabrata Upc2A transcription factor is a global regulator of antifungal drug resistance pathways

Contribution of clinically derived mutations in ERG11 to azole resistance in Candida albicans

Emerging threat of triazole-resistant Aspergillus fumigatus

Gain-of-Function Mutations in UPC2 Are a Frequent Cause of ERG11 Upregulation in Azole-Resistant Clinical Isolates of Candida albicans

Mutations in TAC1B : a Novel Genetic Determinant of Clinical Fluconazole Resistance in Candida auris

Mutations in the multi-drug resistance regulator MRR1, followed by loss of heterozygosity, are the main cause of MDR1 overexpression in fluconazole-resistant Candida albicans strains

The transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicans

A Review of Pneumococcal Vaccines: Current Polysaccharide Vaccine Recommendations and Future Protein Antigens

Relative Contribution of the ABC Transporters Cdr1, Pdh1, and Snq2 to Azole Resistance in Candida glabrata

Isavuconazole: Pharmacology, Pharmacodynamics, and Current Clinical Experience with a New Triazole Antifungal Agent

Contribution of Clinically Derived Mutations in the Gene Encoding the Zinc Cluster Transcription Factor Mrr2 to Fluconazole Antifungal Resistance and CDR1 Expression in Candida albicans

In Vitro Activities of the Novel Investigational Tetrazoles VT-1161 and VT-1598 Compared to the Triazole Antifungals against Azole-Resistant Strains and Clinical Isolates of Candida albicans

A Hyperactive Form of the Zinc Cluster Transcription Factor Stb5 Causes YOR1 Overexpression and Beauvericin Resistance in Candida albicans

Delineation of the Direct Contribution of Candida auris ERG11 Mutations to Clinical Triazole Resistance

Weather and climate resilience: effective preparedness through national meteorological and hydrological services (Directions in development: environment and sustainable development)

An A643T Mutation in the Transcription Factor Upc2p Causes Constitutive ERG11 Upregulation and Increased Fluconazole Resistance in Candida albicans

hapE and hmg1 Mutations Are Drivers of cyp51A -Independent Pan-Triazole Resistance in an Aspergillus fumigatus Clinical Isolate

Changes in the Proteome of Candida albicans in Response to Azole, Polyene, and Echinocandin Antifungal Agents

Regulation of Efflux Pump Expression and Drug Resistance by the Transcription Factors Mrr1, Upc2, and Cap1 in Candida albicans

A Systematic Screen Reveals a Diverse Collection of Medications That Induce Antifungal Resistance in Candida Species

Characterization of the Efflux Capability and Substrate Specificity of Aspergillus fumigatus PDR5-like ABC Transporters Expressed in Saccharomyces cerevisiae

A Gain-of-Function Mutation in the Transcription Factor Upc2p Causes Upregulation of Ergosterol Biosynthesis Genes and Increased Fluconazole Resistance in a Clinical Candida albicans Isolate

UPC2 is universally essential for azole antifungal resistance in Candida albicans

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