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Phase I Trial of a Yeast-Based Therapeutic Cancer Vaccine (GI-6301) Targeting the Transcription Factor Brachyury

Cancer immunology research, 2015-11, Vol.3 (11), p.1248-1256

2015

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Whole Recombinant Saccharomyces cerevisiae Yeast Expressing Ras Mutations as Treatment for Patients With Solid Tumors Bearing Ras Mutations: Results From a Phase 1 Trial

Journal of immunotherapy (1997), 2018-04, Vol.41 (3), p.141

2018

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Safety, tolerability and immunogenicity of GS-4774, a hepatitis B virus-specific therapeutic vaccine, in healthy subjects: A randomized study

Vaccine, 2014-09, Vol.32 (39), p.4925-4931

2014

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A randomized, placebo-controlled trial of oral beclomethasone dipropionate as a prednisone-sparing therapy for gastrointestinal graft-versus-host disease

Blood, 2007-05, Vol.109 (10), p.4557-4563

2007

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Construction and Immunogenicity Testing of Whole Recombinant Yeast-Based T-Cell Vaccines

Methods in molecular biology (Clifton, N.J.), 2016-01, Vol.1404, p.529

2016

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Identification and characterization of a cytotoxic T-lymphocyte agonist epitope of brachyury, a transcription factor involved in epithelial to mesenchymal transition and metastasis

Cancer Immunology, Immunotherapy, 2014-12, Vol.63 (12), p.1307-1317

2014

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Whole recombinant yeast-based immunotherapy induces potent T cell responses targeting HCV NS3 and Core proteins

Vaccine, 2007-02, Vol.25 (8), p.1452-1463

2007

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A Phase 2 Randomized Placebo-Controlled Adjuvant Trial of GI-4000, a Recombinant Yeast Expressing Mutated RAS Proteins in Patients with Resected Pancreas Cancer

Journal of pancreatic cancer, 2021-03, Vol.7 (1), p.8-19

2021

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Mutation-selective tumor remission with ras-targeted, whole yeast-based immunotherapy

Cancer research (Chicago, Ill.), 2004-08, Vol.64 (15), p.5084-5088

2004

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Yeasts encoding tumour antigens in cancer immunotherapy

Expert opinion on biological therapy, 2005-04, Vol.5 (4), p.565-575

2005

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Identification of tumor associated immune responses against brachyury, a transcription factor and driver of EMT, in chordoma patients receiving a yeast-brachyury vaccine (gi-6301)

Journal for immunotherapy of cancer, 2014-11, Vol.2 (Suppl 3), p.P148-P148, Article P148

2014

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Abstract 4509: Targeting tumor-derived exosomes using a lectin affinity hemofiltration device

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.4509-4509

2020

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Randomized phase II study of GS-4774 as a therapeutic vaccine in virally suppressed patients with chronic hepatitis B

Journal of hepatology, 2016-09, Vol.65 (3), p.509-516

2016

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GI-19007, a Novel Saccharomyces cerevisiae-Based Therapeutic Vaccine against Tuberculosis

Clinical and vaccine immunology, 2017-12, Vol.24 (12)

2017

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Abstract A28: Immune responses to mutated Ras - development of a yeast-based immunotherapeutic

Molecular cancer research, 2014-12, Vol.12 (12_Supplement), p.A28-A28

2014

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A phase I study of a yeast-based therapeutic cancer vaccine, GI-6301, targeting brachyury in patients with metastatic carcinoma

Journal of clinical oncology, 2014-05, Vol.32 (15_suppl), p.e14026-e14026

2014

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NCI experience using yeast-brachyury vaccine (GI-6301) in patients (pts) with advanced chordoma

Journal of clinical oncology, 2014-05, Vol.32 (15_suppl), p.3081-3081

2014

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Abstract 5314: A proteomic signature predicts response to a therapeutic vaccine in pancreas cancer; analysis from the GI-4000-02 trial

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.5314-5314

2014

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A pilot trial of a combination of therapeutic vaccines (GI-4000 and GI-6207) as adjunctive therapy with first-line therapy with bevacizumab plus either FOLFOX or FOLFIRI in stage IV patients with newly diagnosed Ras-mutant positive or negative metastatic colorectal cancer

Journal of clinical oncology, 2012-05, Vol.30 (15_suppl), p.TPS3638-TPS3638

2012

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A randomized, placebo-controlled trial of oral beclomethasone dipropionate as a prednisone-sparing therapy for gastrointestinal graft-versus-host disease. Commentary

Blood, 2007, Vol.109 (10)

2007

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Orally administered glutathione peroxidase-mimetic (BXT-51072) is a potent anti-oxidant: Protection against oxidation & nitration of inflamed colonic mucosa in patients with ulcerative colitis [UC]

Gastroenterology (New York, N.Y. 1943), 2000-04, Vol.118 (4), p.A589-A589

2000

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Combined GS-4774 and Tenofovir Therapy Can Improve HBV-Specific T-Cell Responses in Patients With Chronic Hepatitis

Phase I Trial of a Yeast-Based Therapeutic Cancer Vaccine (GI-6301) Targeting the Transcription Factor Brachyury

Whole Recombinant Saccharomyces cerevisiae Yeast Expressing Ras Mutations as Treatment for Patients With Solid Tumors Bearing Ras Mutations: Results From a Phase 1 Trial

Safety, tolerability and immunogenicity of GS-4774, a hepatitis B virus-specific therapeutic vaccine, in healthy subjects: A randomized study

A randomized, placebo-controlled trial of oral beclomethasone dipropionate as a prednisone-sparing therapy for gastrointestinal graft-versus-host disease

Construction and Immunogenicity Testing of Whole Recombinant Yeast-Based T-Cell Vaccines

A whole recombinant yeast-based therapeutic vaccine elicits HBV X, S and Core specific T cells in mice and activates human T cells recognizing epitopes linked to viral clearance

Identification and characterization of a cytotoxic T-lymphocyte agonist epitope of brachyury, a transcription factor involved in epithelial to mesenchymal transition and metastasis

Whole recombinant yeast-based immunotherapy induces potent T cell responses targeting HCV NS3 and Core proteins

A Phase 2 Randomized Placebo-Controlled Adjuvant Trial of GI-4000, a Recombinant Yeast Expressing Mutated RAS Proteins in Patients with Resected Pancreas Cancer

Mutation-selective tumor remission with ras-targeted, whole yeast-based immunotherapy

Yeasts encoding tumour antigens in cancer immunotherapy

Identification of tumor associated immune responses against brachyury, a transcription factor and driver of EMT, in chordoma patients receiving a yeast-brachyury vaccine (gi-6301)

Abstract 4509: Targeting tumor-derived exosomes using a lectin affinity hemofiltration device

Randomized phase II study of GS-4774 as a therapeutic vaccine in virally suppressed patients with chronic hepatitis B

GI-19007, a Novel Saccharomyces cerevisiae-Based Therapeutic Vaccine against Tuberculosis

Abstract A28: Immune responses to mutated Ras - development of a yeast-based immunotherapeutic

A phase I study of a yeast-based therapeutic cancer vaccine, GI-6301, targeting brachyury in patients with metastatic carcinoma

NCI experience using yeast-brachyury vaccine (GI-6301) in patients (pts) with advanced chordoma

Abstract 5314: A proteomic signature predicts response to a therapeutic vaccine in pancreas cancer; analysis from the GI-4000-02 trial

A pilot trial of a combination of therapeutic vaccines (GI-4000 and GI-6207) as adjunctive therapy with first-line therapy with bevacizumab plus either FOLFOX or FOLFIRI in stage IV patients with newly diagnosed Ras-mutant positive or negative metastatic colorectal cancer

A randomized, placebo-controlled, double blind, multicenter phase II adjuvant trial of the efficacy, immunogenicity, and safety of GI-4000 plus gem versus gem alone in patients with resected pancreas cancer with activating RAS mutations/survival and immunology analysis of the R1 subgroup

O-0002 A Phase 2 Adjuvant Trial of GI-4000 Plus Gemcitabine vs. Gemcitabine Alone in Ras+ Patients with Resected Pancreas Cancer: R1 Subgroup Analysis

A randomized, placebo-controlled trial of oral beclomethasone dipropionate as a prednisone-sparing therapy for gastrointestinal graft-versus-host disease. Commentary

Orally administered glutathione peroxidase-mimetic (BXT-51072) is a potent anti-oxidant: Protection against oxidation & nitration of inflamed colonic mucosa in patients with ulcerative colitis [UC]

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