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Improving the Treatment of Acute Lymphoblastic Leukemia

Biochemistry (Easton), 2020-09, Vol.59 (35), p.3193-3200

2020

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PMP-diketopiperazine adducts form at the active site of a PLP dependent enzyme involved in formycin biosynthesis

Chemical communications (Cambridge, England), 2019-11, Vol.55 (96), p.1452-1455

2019

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Substrate Distortion and the Catalytic Reaction Mechanism of 5‑Carboxyvanillate Decarboxylase

Journal of the American Chemical Society, 2016-01, Vol.138 (3), p.826-836

2016

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Asparagine synthetase chemotherapy

Annual review of biochemistry, 2006-01, Vol.75 (1), p.629-654

2006

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Structural Basis for a Six Nucleotide Genetic Alphabet

Journal of the American Chemical Society, 2015-06, Vol.137 (21), p.6947-6955

2015

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A sulfoximine-based inhibitor of human asparagine synthetase kills l-asparaginase-resistant leukemia cells

Bioorganic & medicinal chemistry, 2012-10, Vol.20 (19), p.5915-5927

2012

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Functional Characterization of Two PLP-Dependent Enzymes Involved in Capsular Polysaccharide Biosynthesis from Campylobacter jejuni

Biochemistry (Easton), 2021-09, Vol.60 (37), p.2836-2843

2021

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Rhodium-catalyzed direct synthesis of unprotected NH-sulfoximines from sulfoxides

Chemical communications (Cambridge, England), 2014-09, Vol.50 (68), p.9687-9689

2014

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Correction to “Functional Characterization of Two PLP-Dependent Enzymes Involved in Capsular Polysaccharide Biosynthesis from Campylobacter jejuni”

Biochemistry (Easton), 2022-01, Vol.61 (1), p.46-46

2022

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Assigning the EPR Fine Structure Parameters of the Mn(II) Centers in Bacillus subtilis Oxalate Decarboxylase by Site-Directed Mutagenesis and DFT/MM Calculations

Journal of the American Chemical Society, 2014-02, Vol.136 (6), p.2313-2323

2014

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Toward an Expanded Genome: Structural and Computational Characterization of an Artificially Expanded Genetic Information System

Accounts of chemical research, 2017-06, Vol.50 (6), p.1375-1382

2017

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High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity

Communications biology, 2019-09, Vol.2 (1), p.345, Article 345

2019

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Tautomeric Equilibria of Nucleobases in the Hachimoji Expanded Genetic Alphabet

Journal of chemical theory and computation, 2020-04, Vol.16 (4), p.2766-2777

2020

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Second-Shell Hydrogen Bond Impacts Transition-State Structure in Bacillus subtilis Oxalate Decarboxylase

Biochemistry (Easton), 2018-06, Vol.57 (24), p.3425-3432

2018

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Formation of Hexacoordinate Mn(III) in Bacillus subtilis Oxalate Decarboxylase Requires Catalytic Turnover

Biochemistry (Easton), 2016-01, Vol.55 (3), p.429-434

2016

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Computational, Structural, and Kinetic Evidence That Vibrio vulnificus FrsA Is Not a Cofactor-Independent Pyruvate Decarboxylase

Biochemistry (Easton), 2013-03, Vol.52 (11), p.1842-1844

2013

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Differential Substrate Specificity and Kinetic Behavior of Escherichia coli YfdW and Oxalobacter formigenes Formyl Coenzyme A Transferase

Journal of Bacteriology, 2008-04, Vol.190 (7), p.2556-2564

2008

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A critical electrostatic interaction mediates inhibitor recognition by human asparagine synthetase

Bioorganic & medicinal chemistry, 2009-09, Vol.17 (18), p.6641-6650

2009

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Experimental and computational snapshots of C-C bond formation in a C-nucleoside synthase

Open biology, 2023-01, Vol.13 (1), p.220287-220287

2023

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Computational Studies of Ammonia Channel Function in Glutamine 5′-Phosphoribosylpyrophosphate Amidotransferase

Biochemistry (Easton), 2009-12, Vol.48 (51), p.12272-12282

2009

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Gas phase RDX decomposition pathways using coupled cluster theory

Physical chemistry chemical physics : PCCP, 2016-09, Vol.18 (37), p.26069-26077

2016

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Substrate Binding Mode and Molecular Basis of a Specificity Switch in Oxalate Decarboxylase

Biochemistry (Easton), 2016-04, Vol.55 (14), p.2163-2173

2016

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A Mechanochemical Switch to Control Radical Intermediates

Biochemistry (Easton), 2014-06, Vol.53 (23), p.3830-3838

2014

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Electronic Structure, Bonding, Spectroscopy and Energetics of Fe-Dependent Nitrile Hydratase Active-Site Models

Inorganic chemistry, 2006-01, Vol.45 (1), p.17-36

2006

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A Conserved Glutamate Controls the Commitment to Acyl-Adenylate Formation in Asparagine Synthetase

Biochemistry (Easton), 2010-11, Vol.49 (43), p.9391-9401

2010

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Improving the Treatment of Acute Lymphoblastic Leukemia

PMP-diketopiperazine adducts form at the active site of a PLP dependent enzyme involved in formycin biosynthesis

Substrate Distortion and the Catalytic Reaction Mechanism of 5‑Carboxyvanillate Decarboxylase

Asparagine synthetase chemotherapy

Structural Basis for a Six Nucleotide Genetic Alphabet

A sulfoximine-based inhibitor of human asparagine synthetase kills l-asparaginase-resistant leukemia cells

Functional Characterization of Two PLP-Dependent Enzymes Involved in Capsular Polysaccharide Biosynthesis from Campylobacter jejuni

Rhodium-catalyzed direct synthesis of unprotected NH-sulfoximines from sulfoxides

Correction to “Functional Characterization of Two PLP-Dependent Enzymes Involved in Capsular Polysaccharide Biosynthesis from Campylobacter jejuni”

Assigning the EPR Fine Structure Parameters of the Mn(II) Centers in Bacillus subtilis Oxalate Decarboxylase by Site-Directed Mutagenesis and DFT/MM Calculations

Toward an Expanded Genome: Structural and Computational Characterization of an Artificially Expanded Genetic Information System

High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity

Tautomeric Equilibria of Nucleobases in the Hachimoji Expanded Genetic Alphabet

Second-Shell Hydrogen Bond Impacts Transition-State Structure in Bacillus subtilis Oxalate Decarboxylase

Formation of Hexacoordinate Mn(III) in Bacillus subtilis Oxalate Decarboxylase Requires Catalytic Turnover

Computational, Structural, and Kinetic Evidence That Vibrio vulnificus FrsA Is Not a Cofactor-Independent Pyruvate Decarboxylase

Differential Substrate Specificity and Kinetic Behavior of Escherichia coli YfdW and Oxalobacter formigenes Formyl Coenzyme A Transferase

A critical electrostatic interaction mediates inhibitor recognition by human asparagine synthetase

Experimental and computational snapshots of C-C bond formation in a C-nucleoside synthase

Computational Studies of Ammonia Channel Function in Glutamine 5′-Phosphoribosylpyrophosphate Amidotransferase

Gas phase RDX decomposition pathways using coupled cluster theory

Substrate Binding Mode and Molecular Basis of a Specificity Switch in Oxalate Decarboxylase

A Mechanochemical Switch to Control Radical Intermediates

Electronic Structure, Bonding, Spectroscopy and Energetics of Fe-Dependent Nitrile Hydratase Active-Site Models

A Conserved Glutamate Controls the Commitment to Acyl-Adenylate Formation in Asparagine Synthetase

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