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Efficient and Selective Enzymatic Acylation Reaction: Separation of Furanosyl and Pyranosyl Nucleosides

Journal of organic chemistry, 2008-07, Vol.73 (14), p.5629-5632

2008

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‘Green’ methodology for efficient and selective benzoylation of nucleosides using benzoyl cyanide in an ionic liquid

Bioorganic & medicinal chemistry, 2005-07, Vol.13 (14), p.4467-4472

2005

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UnyLinker: An Efficient and Scaleable Synthesis of Oligonucleotides Utilizing a Universal Linker Molecule: A Novel Approach To Enhance the Purity of Drugs

Organic process research & development, 2008-05, Vol.12 (3), p.399-410

2008

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Synthesis of High-Quality Antisense Drugs. Addition of Acrylonitrile to Phosphorothioate Oligonucleotides: Adduct Characterization and Avoidance

Organic process research & development, 2003-11, Vol.7 (6), p.832-838

2003

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Antisense oligonucleotides : Efficient synthesis of 2'-O-methoxyethyl phosphorothioate oligonucleotides using 4,5-dicyanoimidazole. Are these oligonucleotides comparable to those synthesized using 1H-tetrazole as coupling activator?

Bioorganic & medicinal chemistry, 2006-07, Vol.14 (14), p.5049-5060

2006

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Human RNase H1 Uses One Tryptophan and Two Lysines to Position the Enzyme at the 3′-DNA/5′-RNA Terminus of the Heteroduplex Substrate

The Journal of biological chemistry, 2003-12, Vol.278 (50), p.49860-49867

2003

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Characterization of high molecular weight impurities in synthetic phosphorothioate oligonucleotides

Bioorganic & medicinal chemistry letters, 2006-02, Vol.16 (3), p.607-614

2006

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An Efficient and Scalable Synthesis of 2,6-Diaminopurine Riboside

Nucleosides, nucleotides & nucleic acids, 2008-01, Vol.27 (1), p.67-69

2008

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Development of siRNA for therapeutics: Efficient synthesis of phosphorothioate RNA utilizing phenylacetyl disulfide (PADS)

Bioorganic & medicinal chemistry letters, 2006-05, Vol.16 (9), p.2513-2517

2006

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A Novel Universal Linker for Efficient Synthesis of Phosphorothioate Oligonucleotides

Nucleosides, nucleotides & nucleic acids, 2007-01, Vol.26 (3), p.259-269

2007

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An Alternative Advantageous Protocol for Efficient Synthesis of Phosphorothioate Oligonucleotides Utilizing Phenylacetyl Disulfide (PADS)

Nucleosides, nucleotides & nucleic acids, 2007-01, Vol.26 (2), p.181-188

2007

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Formation of 4,4′-dimethoxytrityl- C-phosphonate oligonucleotides

Bioorganic & medicinal chemistry letters, 2004-09, Vol.14 (18), p.4683-4690

2004

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4,4′-Dimethoxytrityl group derived from secondary alcohols: Are they removed slowly under acidic conditions?

Bioorganic & medicinal chemistry letters, 2005-07, Vol.15 (14), p.3426-3429

2005

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(2-Acetoxyphenoxy)ethyl (APOE) as a Phosphate Protecting Group in Solid-Phase Synthesis of Oligonucleotides via the Phosphoramidite Approach

Organic process research & development, 2006-03, Vol.10 (2), p.251-256

2006

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A novel solid support for synthesis of oligonucleotide 3′-phosphorothioate monoesters

Bioorganic & medicinal chemistry letters, 2003-01, Vol.13 (2), p.281-284

2003

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Process Research on the Preparation of DMT Protected 2′-O-Methoxyethylguanosine for Oligonucleotide Synthesis in Therapeutic Applications

Nucleosides, nucleotides & nucleic acids, 2008-09, Vol.27 (9), p.1024-1033

2008

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Development of 2‘-O-Methoxyethyl Phosphorothioate Oligonucleotides as Antisense Drugs under Stereochemical Control

Organic process research & development, 2002-11, Vol.6 (6), p.798-806

2002

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Antisense phosphorothioate oligodeoxyribonucleotide targeted against ICAM-1: synthetic and biological characterization of a process-related impurity formed during oligonucleotide synthesis

Bioorganic & medicinal chemistry, 2003-10, Vol.11 (21), p.4673-4679

2003

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Controlled Detritylation of Antisense Oligonucleotides

Organic process research & development, 2003-01, Vol.7 (1), p.47-52

2003

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Synthesis of Antisense Oligonucleotides: Replacement of 3H-1,2-Benzodithiol-3-one 1,1-Dioxide (Beaucage Reagent) with Phenylacetyl Disulfide (PADS) As Efficient Sulfurization Reagent: From Bench to Bulk Manufacture of Active Pharmaceutical Ingredient

Organic process research & development, 2000-05, Vol.4 (3), p.199-204

2000

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Synthesis of an antisense oligonucleotide targeted against C-raf kinase: efficient oligonucleotide synthesis without chlorinated solvents

Bioorganic & medicinal chemistry, 1999-03, Vol.7 (3), p.435-439

1999

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Diastereomeric Process Control in the Synthesis of 2′-O-(2-Methoxyethyl) Oligoribonucleotide Phosphorothioates as Antisense Drugs

Nucleosides, nucleotides & nucleic acids, 2003-10, Vol.22 (5-8), p.1639-1645

2003

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Antisense Phosphorothioate Oligodeoxyribonucleotide Targeted against ICAM-1: Use of I-Linker to Eliminate 3‘-Terminal Phosphorothioate Monoester Formation

Organic process research & development, 2003-05, Vol.7 (3), p.259-266

2003

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Understanding High Diastereomeric Discrimination in Formation of Oligoribonucleotide Phosphorothioate Linkages: The First Study of pKa-Dependent Activation in Solid-Supported Coupling of 2′-O-Substituted Ribonucleoside Phosphoramidites

Nucleosides, nucleotides & nucleic acids, 2003-10, Vol.22 (5-8), p.1415-1419

2003

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Synthesis of antisense oligonucleotides . using environmentally friendly and safe deprotection procedures

Green chemistry : an international journal and green chemistry resource : GC, 1999, Vol.1 (6), p.277-282

1999

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Efficient and Selective Enzymatic Acylation Reaction: Separation of Furanosyl and Pyranosyl Nucleosides

‘Green’ methodology for efficient and selective benzoylation of nucleosides using benzoyl cyanide in an ionic liquid

UnyLinker: An Efficient and Scaleable Synthesis of Oligonucleotides Utilizing a Universal Linker Molecule: A Novel Approach To Enhance the Purity of Drugs

Synthesis of High-Quality Antisense Drugs. Addition of Acrylonitrile to Phosphorothioate Oligonucleotides: Adduct Characterization and Avoidance

Antisense oligonucleotides : Efficient synthesis of 2'-O-methoxyethyl phosphorothioate oligonucleotides using 4,5-dicyanoimidazole. Are these oligonucleotides comparable to those synthesized using 1H-tetrazole as coupling activator?

Human RNase H1 Uses One Tryptophan and Two Lysines to Position the Enzyme at the 3′-DNA/5′-RNA Terminus of the Heteroduplex Substrate

Characterization of high molecular weight impurities in synthetic phosphorothioate oligonucleotides

An Efficient and Scalable Synthesis of 2,6-Diaminopurine Riboside

Development of siRNA for therapeutics: Efficient synthesis of phosphorothioate RNA utilizing phenylacetyl disulfide (PADS)

A Novel Universal Linker for Efficient Synthesis of Phosphorothioate Oligonucleotides

An Alternative Advantageous Protocol for Efficient Synthesis of Phosphorothioate Oligonucleotides Utilizing Phenylacetyl Disulfide (PADS)

Formation of 4,4′-dimethoxytrityl- C-phosphonate oligonucleotides

4,4′-Dimethoxytrityl group derived from secondary alcohols: Are they removed slowly under acidic conditions?

(2-Acetoxyphenoxy)ethyl (APOE) as a Phosphate Protecting Group in Solid-Phase Synthesis of Oligonucleotides via the Phosphoramidite Approach

A novel solid support for synthesis of oligonucleotide 3′-phosphorothioate monoesters

Process Research on the Preparation of DMT Protected 2′-O-Methoxyethylguanosine for Oligonucleotide Synthesis in Therapeutic Applications

Development of 2‘-O-Methoxyethyl Phosphorothioate Oligonucleotides as Antisense Drugs under Stereochemical Control

Antisense phosphorothioate oligodeoxyribonucleotide targeted against ICAM-1: synthetic and biological characterization of a process-related impurity formed during oligonucleotide synthesis

Controlled Detritylation of Antisense Oligonucleotides

Synthesis of Antisense Oligonucleotides: Replacement of 3H-1,2-Benzodithiol-3-one 1,1-Dioxide (Beaucage Reagent) with Phenylacetyl Disulfide (PADS) As Efficient Sulfurization Reagent: From Bench to Bulk Manufacture of Active Pharmaceutical Ingredient

Synthesis of an antisense oligonucleotide targeted against C-raf kinase: efficient oligonucleotide synthesis without chlorinated solvents

Diastereomeric Process Control in the Synthesis of 2′-O-(2-Methoxyethyl) Oligoribonucleotide Phosphorothioates as Antisense Drugs

Antisense Phosphorothioate Oligodeoxyribonucleotide Targeted against ICAM-1: Use of I-Linker to Eliminate 3‘-Terminal Phosphorothioate Monoester Formation

Understanding High Diastereomeric Discrimination in Formation of Oligoribonucleotide Phosphorothioate Linkages: The First Study of pKa-Dependent Activation in Solid-Supported Coupling of 2′-O-Substituted Ribonucleoside Phosphoramidites

Synthesis of antisense oligonucleotides . using environmentally friendly and safe deprotection procedures

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