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Targeting Myosin by Blebbistatin Derivatives: Optimization and Pharmacological Potential

Trends in biochemical sciences (Amsterdam. Regular ed.), 2018-09, Vol.43 (9), p.700-713

2018

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Chiral HPLC separation of enantiomeric blebbistatin derivatives and racemization analysis in vertebrate tissues

Journal of pharmaceutical and biomedical analysis, 2021-09, Vol.204, p.114246-114246, Article 114246

2021

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Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness

Cell, 2020-10, Vol.183 (2), p.335-346.e13

2020

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Cycling Cross-Bridges Contribute to Thin Filament Activation in Human Slow-Twitch Fibers

Frontiers in physiology, 2020-03, Vol.11, p.144-144

2020

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Improved Inhibitory and Absorption, Distribution, Metabolism, Excretion, and Toxicology (ADMET) Properties of Blebbistatin Derivatives Indicate That Blebbistatin Scaffold Is Ideal for drug Development Targeting Myosin-2

The Journal of pharmacology and experimental therapeutics, 2021-03, Vol.376 (3), p.358

2021

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Temperature dependence of internal friction in enzyme reactions

The FASEB journal, 2011-08, Vol.25 (8), p.2804-2813

2011

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Magnesium Modulates Actin Binding and ADP Release in Myosin Motors

The Journal of biological chemistry, 2014-08, Vol.289 (34), p.23977-23991

2014

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Relating the shape of protein binding sites to binding affinity profiles: is there an association?

BMC structural biology, 2010-10, Vol.10 (1), p.32-32, Article 32

2010

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Skeletal, smooth and cardiac muscle myosin 2 are less sensitive for the chiral hydroxyl moiety of blebbistatin than that of non-muscle myosin 2 isoforms

Biophysical journal, 2022-02, Vol.121 (3), p.259a-259a

2022

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Targeted Myosin-2 Inhibition Improves Brain Regeneration After Stroke by Relaxing Hypoxia-Induced Vasoconstriction in Capillaries

Biophysical journal, 2020-02, Vol.118 (3), p.434a-435a

2020

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First-in-class drug candidate (MPH-220) efficiently improves spastic gait disorders by selective inhibition of fast skeletal muscle myosin-2

Biophysical journal, 2022-02, Vol.121 (3), p.291a-291a

2022

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Highly Soluble, Non-Phototoxic, Non-Fluorescent, Photostable Blebbistatin Derivatives

Biophysical journal, 2017-02, Vol.112 (3), p.266a-267a

2017

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Molecular Tattoo: Subcellular Confinement of Drug Effects In Vivo with Two-Photon Microscopy

Biophysical journal, 2017-02, Vol.112 (3), p.149a-150a

2017

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Non-Thermal Induction of Conforamtional Rearrangment in Proteins by Far-Infrared Excitation

Biophysical journal, 2014-01, Vol.106 (2), p.460a-460a

2014

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A Structural Model of Actomyosin in the Prepowerstroke State: Actin Binding Induced Extra Priming of Myosin

Biophysical journal, 2013-01, Vol.104 (2), p.307a-308a

2013

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Relationship Between Internal Friction and the Roughness of the Energy Landscape of Protein Conformational Changes

Biophysical journal, 2011-02, Vol.100 (3), p.537a-537a

2011

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Molecular Tattoo: Subcellular Confinement of Drug Effects

Chemistry & biology, 2015-04, Vol.22 (4), p.548-558

2015

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A Model with Two Elastically Coupled Reaction Coordinates for the Internal Friction of Proteins

Biophysical journal, 2012-01, Vol.102 (3), p.52a-52a

2012

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Protein Flexibility Partitions the Effects of Energy Landscape Roughness Between Activation Energy and Internal Friction

Biophysical journal, 2011-02, Vol.100 (3), p.537a-537a

2011

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National Performance Benchmarks for Modern Screening Digital Mammography: Update from the Breast Cancer Surveillance Consortium

Radiology, 2017-04, Vol.283 (1), p.49

2017

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National Performance Benchmarks for Modern Diagnostic Digital Mammography: Update from the Breast Cancer Surveillance Consortium

Radiology, 2017-04, Vol.283 (1), p.59

2017

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Cumulative Advanced Breast Cancer Risk Prediction Model Developed in a Screening Mammography Population

JNCI : Journal of the National Cancer Institute, 2022-05, Vol.114 (5), p.676-685

2022

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National Performance Benchmarks for Screening Digital Breast Tomosynthesis: Update from the Breast Cancer Surveillance Consortium

Radiology, 2023-05, Vol.307 (4), p.e222499-e222499

2023

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Screening Performance of Digital Breast Tomosynthesis vs Digital Mammography in Community Practice by Patient Age, Screening Round, and Breast Density

JAMA network open, 2020-07, Vol.3 (7), p.e2011792-e2011792

2020

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Changes in Mammography Use by Women's Characteristics During the First 5 Months of the COVID-19 Pandemic

JNCI : Journal of the National Cancer Institute, 2021-09, Vol.113 (9), p.1161-1167

2021

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Targeting Myosin by Blebbistatin Derivatives: Optimization and Pharmacological Potential

Chiral HPLC separation of enantiomeric blebbistatin derivatives and racemization analysis in vertebrate tissues

Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness

Cycling Cross-Bridges Contribute to Thin Filament Activation in Human Slow-Twitch Fibers

Improved Inhibitory and Absorption, Distribution, Metabolism, Excretion, and Toxicology (ADMET) Properties of Blebbistatin Derivatives Indicate That Blebbistatin Scaffold Is Ideal for drug Development Targeting Myosin-2

Temperature dependence of internal friction in enzyme reactions

Magnesium Modulates Actin Binding and ADP Release in Myosin Motors

Relating the shape of protein binding sites to binding affinity profiles: is there an association?

Skeletal, smooth and cardiac muscle myosin 2 are less sensitive for the chiral hydroxyl moiety of blebbistatin than that of non-muscle myosin 2 isoforms

Targeted Myosin-2 Inhibition Improves Brain Regeneration After Stroke by Relaxing Hypoxia-Induced Vasoconstriction in Capillaries

First-in-class drug candidate (MPH-220) efficiently improves spastic gait disorders by selective inhibition of fast skeletal muscle myosin-2

Highly Soluble, Non-Phototoxic, Non-Fluorescent, Photostable Blebbistatin Derivatives

Molecular Tattoo: Subcellular Confinement of Drug Effects In Vivo with Two-Photon Microscopy

Non-Thermal Induction of Conforamtional Rearrangment in Proteins by Far-Infrared Excitation

A Structural Model of Actomyosin in the Prepowerstroke State: Actin Binding Induced Extra Priming of Myosin

Relationship Between Internal Friction and the Roughness of the Energy Landscape of Protein Conformational Changes

Molecular Tattoo: Subcellular Confinement of Drug Effects

A Model with Two Elastically Coupled Reaction Coordinates for the Internal Friction of Proteins

Protein Flexibility Partitions the Effects of Energy Landscape Roughness Between Activation Energy and Internal Friction

National Performance Benchmarks for Modern Screening Digital Mammography: Update from the Breast Cancer Surveillance Consortium

National Performance Benchmarks for Modern Diagnostic Digital Mammography: Update from the Breast Cancer Surveillance Consortium

Cumulative Advanced Breast Cancer Risk Prediction Model Developed in a Screening Mammography Population

National Performance Benchmarks for Screening Digital Breast Tomosynthesis: Update from the Breast Cancer Surveillance Consortium

Screening Performance of Digital Breast Tomosynthesis vs Digital Mammography in Community Practice by Patient Age, Screening Round, and Breast Density

Changes in Mammography Use by Women's Characteristics During the First 5 Months of the COVID-19 Pandemic

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