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PINK1/PARKIN signalling in neurodegeneration and neuroinflammation

Acta neuropathologica communications, 2020-11, Vol.8 (1), p.189-189, Article 189

2020

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The Role of Small Molecules and Their Effect on the Molecular Mechanisms of Early Retinal Organoid Development

International journal of molecular sciences, 2021-06, Vol.22 (13), p.7081

2021

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Analysis of CRB1 Pathogenic Variants Correctable with CRISPR Base and Prime Editing

Retinal Degenerative Diseases XIX, p.103-107

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CRB2 in immature photoreceptors determines the superior-inferior symmetry of the developing retina to maintain retinal structure and function

Human molecular genetics, 2018-09, Vol.27 (18), p.3137-3153

2018

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A novel pathogenic CRB1 variant presenting as Leber Congenital Amaurosis 8 and evaluation of gene editing feasibility

Documenta ophthalmologica, 2023-12, Vol.147 (3), p.217-224

2023

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Targeted ablation of CRB1 and CRB2 in retinal progenitor cells mimics Leber congenital amaurosis

PLoS genetics, 2013-12, Vol.9 (12), p.e1003976-e1003976

2013

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The CRB1 Complex: Following the Trail of Crumbs to a Feasible Gene Therapy Strategy

Frontiers in neuroscience, 2017-04, Vol.11, p.175-175

2017

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Generation of an Avian Myeloblastosis Virus (AMV) Reverse Transcriptase Prime Editor

Retinal Degenerative Diseases XIX, p.109-114

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Retinogenesis of the Human Fetal Retina: An Apical Polarity Perspective

Genes, 2019-11, Vol.10 (12), p.987

2019

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Oxidative Stress, Neuroinflammation and Neurodegeneration: The Chicken, the Egg and the Dinosaur

Antioxidants, 2022-08, Vol.11 (8), p.1554

2022

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Prime Editing Strategy to Install the PRPH2 c.828+1G>A Mutation

Retinal Degenerative Diseases XIX, p.97-102

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Generation of CRB1 RP Patient-Derived iPSCs and a CRISPR/Cas9-Mediated Homology-Directed Repair Strategy for the CRB1 c.2480G>T Mutation

Retinal Degenerative Diseases XIX, p.571-576

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Role of Oxidative Stress in Ocular Diseases Associated with Retinal Ganglion Cells Degeneration

Antioxidants, 2021-12, Vol.10 (12), p.1948

2021

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Defining Phenotype, Tropism, and Retinal Gene Therapy Using Adeno-Associated Viral Vectors (AAVs) in New-Born Brown Norway Rats with a Spontaneous Mutation in Crb1

International journal of molecular sciences, 2021-03, Vol.22 (7), p.3563

2021

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HIF2α activation and mitochondrial deficit due to iron chelation cause retinal atrophy

EMBO molecular medicine, 2023-02, Vol.15 (2), p.e16525-n/a

2023

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TRAP1 Is Expressed in Human Retinal Pigment Epithelial Cells and Is Required to Maintain their Energetic Status

Antioxidants, 2023-02, Vol.12 (2), p.381

2023

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Prime Editing for Inherited Retinal Diseases

Frontiers in genome editing, 2021-11, Vol.3, p.775330-775330

2021

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Mouse Models of Achromatopsia in Addressing Temporal "Point of No Return" in Gene-Therapy

International journal of molecular sciences, 2021-07, Vol.22 (15), p.8069

2021

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Clinical and Therapeutic Evaluation of the Ten Most Prevalent CRB1 Mutations

Biomedicines, 2023-01, Vol.11 (2), p.385

2023

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CRISPR/Cas therapeutic strategies for autosomal dominant disorders

The Journal of clinical investigation, 2022-05, Vol.132 (9), p.1-11

2022

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Phase transition specified by a binary code patterns the vertebrate eye cup

Science advances, 2021-11, Vol.7 (46), p.eabj9846-eabj9846

2021

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Overcoming translational barriers in modeling macular degenerations

Cell stem cell, 2021-05, Vol.28 (5), p.781-783

2021

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Organoids and organ chips in ophthalmology

The ocular surface, 2021-01, Vol.19, p.1-15

2021

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CRISPR genome surgery in a novel humanized model for autosomal dominant retinitis pigmentosa

Molecular therapy, 2022-04, Vol.30 (4), p.1407-1420

2022

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PINK1/PARKIN signalling in neurodegeneration and neuroinflammation

The Role of Small Molecules and Their Effect on the Molecular Mechanisms of Early Retinal Organoid Development

Analysis of CRB1 Pathogenic Variants Correctable with CRISPR Base and Prime Editing

CRB2 in immature photoreceptors determines the superior-inferior symmetry of the developing retina to maintain retinal structure and function

A novel pathogenic CRB1 variant presenting as Leber Congenital Amaurosis 8 and evaluation of gene editing feasibility

Targeted ablation of CRB1 and CRB2 in retinal progenitor cells mimics Leber congenital amaurosis

The CRB1 Complex: Following the Trail of Crumbs to a Feasible Gene Therapy Strategy

Generation of an Avian Myeloblastosis Virus (AMV) Reverse Transcriptase Prime Editor

Retinogenesis of the Human Fetal Retina: An Apical Polarity Perspective

Human iPSC-Derived Retinas Recapitulate the Fetal CRB1 CRB2 Complex Formation and Demonstrate that Photoreceptors and Müller Glia Are Targets of AAV5

Oxidative Stress, Neuroinflammation and Neurodegeneration: The Chicken, the Egg and the Dinosaur

Prime Editing Strategy to Install the PRPH2 c.828+1G>A Mutation

Generation of CRB1 RP Patient-Derived iPSCs and a CRISPR/Cas9-Mediated Homology-Directed Repair Strategy for the CRB1 c.2480G>T Mutation

Role of Oxidative Stress in Ocular Diseases Associated with Retinal Ganglion Cells Degeneration

Defining Phenotype, Tropism, and Retinal Gene Therapy Using Adeno-Associated Viral Vectors (AAVs) in New-Born Brown Norway Rats with a Spontaneous Mutation in Crb1

HIF2α activation and mitochondrial deficit due to iron chelation cause retinal atrophy

TRAP1 Is Expressed in Human Retinal Pigment Epithelial Cells and Is Required to Maintain their Energetic Status

Prime Editing for Inherited Retinal Diseases

Mouse Models of Achromatopsia in Addressing Temporal "Point of No Return" in Gene-Therapy

Clinical and Therapeutic Evaluation of the Ten Most Prevalent CRB1 Mutations

CRISPR/Cas therapeutic strategies for autosomal dominant disorders

Phase transition specified by a binary code patterns the vertebrate eye cup

Overcoming translational barriers in modeling macular degenerations

Organoids and organ chips in ophthalmology

CRISPR genome surgery in a novel humanized model for autosomal dominant retinitis pigmentosa

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