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Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects

International journal of molecular sciences, 2015-01, Vol.16 (1), p.1008-1029

2015

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Regulation of IL-17A production is distinct from IL-17F in a primary human cell co-culture model of T cell-mediated B cell activation

PloS one, 2013-03, Vol.8 (3), p.e58966-e58966

2013

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Building predictive models for mechanism-of-action classification from phenotypic assay data sets

Journal of biomolecular screening, 2013-12, Vol.18 (10), p.1260-1269

2013

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Novel Small Molecule Inhibitors of 3-Phosphoinositide-dependent Kinase-1

The Journal of biological chemistry, 2005-05, Vol.280 (20), p.19867-19874

2005

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Mechanistic Studies with Potent and Selective Inducible Nitric-oxide Synthase Dimerization Inhibitors

The Journal of biological chemistry, 2002-01, Vol.277 (1), p.295-302

2002

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Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: Optimization of BX- 517

Bioorganic & medicinal chemistry letters, 2007-07, Vol.17 (14), p.3819-3825

2007

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Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: Design, synthesis and biological activity

Bioorganic & medicinal chemistry letters, 2007-07, Vol.17 (14), p.3814-3818

2007

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Potent Triazolothione Inhibitor of Heat-Shock Protein-90

Chemical biology & drug design, 2009-07, Vol.74 (1), p.43-50

2009

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Allosteric Inhibitors of Inducible Nitric Oxide Synthase Dimerization Discovered via Combinatorial Chemistry

Proceedings of the National Academy of Sciences - PNAS, 2000-02, Vol.97 (4), p.1506-1511

2000

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Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms

Nature biotechnology, 2014-06, Vol.32 (6), p.583-591

2014

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Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt

Cancer research (Chicago, Ill.), 2004-07, Vol.64 (13), p.4394-4399

2004

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Elucidating adverse outcome pathways with phenotypic data from primary human cell systems

Toxicology letters, 2014-09, Vol.229, p.S55-S55

2014

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A Novel High-Throughput Screening Format to Identify Inhibitors of Secreted Acid Sphingomyelinase

Journal of biomolecular screening, 2005-04, Vol.10 (3), p.225-234

2005

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Design, Synthesis, and Activity of 2-Imidazol-1-ylpyrimidine Derived Inducible Nitric Oxide Synthase Dimerization Inhibitors

Journal of medicinal chemistry, 2007-03, Vol.50 (6), p.1146-1157

2007

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Antibodies neutralizing hepsin protease activity do not impact cell growth but inhibit invasion of prostate and ovarian tumor cells in culture

Cancer research (Chicago, Ill.), 2006-04, Vol.66 (7), p.3611-3619

2006

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Hydroxamic Acids as Potent Inhibitors of Endothelin-Converting Enzyme from Human Bronchiolar Smooth Muscle

Journal of medicinal chemistry, 1995-06, Vol.38 (12), p.2119-2129

1995

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Abstract 1093: BioMAP® profiling in primary human cell systems as a tool for drug discovery in inflammation and cancer

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.1093-1093

2011

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Yeast thioltransferase—The active site cysteines display differential reactivity

Archives of biochemistry and biophysics, 1990-10, Vol.282 (1), p.110-115

1990

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Disintegrins: A Family of Integrin Inhibitory Proteins from Viper Venoms

Proceedings of the Society for Experimental Biology and Medicine, 1990-11, Vol.195 (2), p.168-171

1990

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1-(1,3-Benzodioxol-5-ylmethyl)-3-[4-(1 H-imidazol-1-yl)phenoxy]-piperidine analogs as potent and selective inhibitors of nitric oxide formation

Bioorganic & medicinal chemistry letters, 2007-05, Vol.17 (9), p.2499-2504

2007

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Chronic ethanol increases liver plasma membrane fluidity

Biochemistry (Easton), 1985-06, Vol.24 (13), p.3114-3120

1985

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The rational design of inhibitors of nitric oxide formation by inducible nitric oxide synthase

Bioorganic & medicinal chemistry letters, 2007-05, Vol.17 (9), p.2505-2508

2007

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Evidence of Glycosylated Sites on the Endothelin-1 Receptor in Swiss 3T3 Cells

Journal of cardiovascular pharmacology, 1991, Vol.17 Suppl 7, p.S134-136

1991

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Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects

Regulation of IL-17A production is distinct from IL-17F in a primary human cell co-culture model of T cell-mediated B cell activation

Building predictive models for mechanism-of-action classification from phenotypic assay data sets

Novel Small Molecule Inhibitors of 3-Phosphoinositide-dependent Kinase-1

Characterization of Novel PI3Kδ Inhibitors as Potential Therapeutics for SLE and Lupus Nephritis in Pre-Clinical Studies

Mechanistic Studies with Potent and Selective Inducible Nitric-oxide Synthase Dimerization Inhibitors

Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: Optimization of BX- 517

Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: Design, synthesis and biological activity

Potent Triazolothione Inhibitor of Heat-Shock Protein-90

Allosteric Inhibitors of Inducible Nitric Oxide Synthase Dimerization Discovered via Combinatorial Chemistry

Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms

Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt

Characterization of Novel PI3KÎ´ Inhibitors as Potential Therapeutics for SLE and Lupus Nephritis in Pre-Clinical Studies

Elucidating adverse outcome pathways with phenotypic data from primary human cell systems

A Novel High-Throughput Screening Format to Identify Inhibitors of Secreted Acid Sphingomyelinase

Design, Synthesis, and Activity of 2-Imidazol-1-ylpyrimidine Derived Inducible Nitric Oxide Synthase Dimerization Inhibitors

Antibodies neutralizing hepsin protease activity do not impact cell growth but inhibit invasion of prostate and ovarian tumor cells in culture

Hydroxamic Acids as Potent Inhibitors of Endothelin-Converting Enzyme from Human Bronchiolar Smooth Muscle

Abstract 1093: BioMAP® profiling in primary human cell systems as a tool for drug discovery in inflammation and cancer

Yeast thioltransferase—The active site cysteines display differential reactivity

Disintegrins: A Family of Integrin Inhibitory Proteins from Viper Venoms

1-(1,3-Benzodioxol-5-ylmethyl)-3-[4-(1 H-imidazol-1-yl)phenoxy]-piperidine analogs as potent and selective inhibitors of nitric oxide formation

Chronic ethanol increases liver plasma membrane fluidity

The rational design of inhibitors of nitric oxide formation by inducible nitric oxide synthase

Evidence of Glycosylated Sites on the Endothelin-1 Receptor in Swiss 3T3 Cells

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