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Genetics of substance use disorders in the era of big data

Nature reviews. Genetics, 2021-11, Vol.22 (11), p.712

2021

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Widespread signatures of positive selection in common risk alleles associated to autism spectrum disorder

PLoS genetics, 2017-02, Vol.13 (2), p.e1006618-e1006618

2017

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ADH1B: From alcoholism, natural selection, and cancer to the human phenome

American journal of medical genetics. Part B, Neuropsychiatric genetics, 2018-03, Vol.177 (2), p.113-125

2018

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Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations

Nature communications, 2019-04, Vol.10 (1), p.1499-11, Article 1499

2019

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Reproducible Genetic Risk Loci for Anxiety: Results From ∼200,000 Participants in the Million Veteran Program

The American journal of psychiatry, 2020-03, Vol.177 (3), p.223-232

2020

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Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions

Nature neuroscience, 2021-07, Vol.24 (7), p.954

2021

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Phenome-wide association study of loci harboring de novo tandem repeat mutations in UK Biobank exomes

Nature communications, 2022-12, Vol.13 (1), p.7682-7682

2022

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Potential causal association between leisure sedentary behaviors, physical activity and musculoskeletal health: A Mendelian randomization study

PloS one, 2023-03, Vol.18 (3), p.e0283014-e0283014

2023

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Four modifiable factors that mediate the effect of educational time on major depressive disorder risk: A network Mendelian randomization study

PloS one, 2023-07, Vol.18 (7), p.e0288034-e0288034

2023

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Causal associations of anthropometric measurements with osteoarthritis: A Mendelian randomization study

PloS one, 2023-01, Vol.18 (1), p.e0279198-e0279198

2023

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Causality of anthropometric markers associated with polycystic ovarian syndrome: Findings of a Mendelian randomization study

PloS one, 2022-06, Vol.17 (6), p.e0269191-e0269191

2022

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Causal relationships between sex hormone traits, lifestyle factors, and osteoporosis in men: A Mendelian randomization study

PloS one, 2022-08, Vol.17 (8), p.e0271898-e0271898

2022

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Not Only Gene Discovery: Genome-wide Association Studies and Polygenic Risk Scores as Tools to Dissect the Heterogeneity of Major Depressive Disorder

Biological psychiatry (1969), 2022-08, Vol.92 (3), p.177-178

Polimanti, Renato

2022

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Not only gene discovery: genome-wide association studies and polygenic risk scoring as tools to dissect the heterogeneity of major depressive disorder

Biological psychiatry (1969), 2022-08, Vol.92 (3), p.177-178

Polimanti, Renato

2022

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Mendelian randomization analysis of plasma levels of CD209 and MICB proteins and the risk of varicose veins of lower extremities

PloS one, 2022-05, Vol.17 (5), p.e0268725-e0268725

2022

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Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers

JAMA psychiatry (Chicago, Ill.), 2016-07, Vol.73 (7), p.695

2016

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Genetic associations with suicide attempt severity and genetic overlap with major depression

Translational psychiatry, 2019-01, Vol.9 (1), p.22-22, Article 22

2019

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Causal linkage between adult height and kidney function: An integrated population-scale observational analysis and Mendelian randomization study

PloS one, 2021-07, Vol.16 (7), p.e0254649-e0254649

2021

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Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium

Molecular psychiatry, 2020-08, Vol.25 (8), p.1673-1687

2020

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Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells

Nature communications, 2022-10, Vol.13 (1), p.6102-15, Article 6102

2022

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Multi-environment gene interactions linked to the interplay between polysubstance dependence and suicidality

Translational psychiatry, 2021-01, Vol.11 (1), p.34-34, Article 34

2021

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Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder

Molecular psychiatry, 2022-04, Vol.27 (4), p.2206-2215

2022

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Psychosocial moderators of polygenic risk for suicidal ideation: Results from a 7-year population-based, prospective cohort study of U.S. veterans

Molecular psychiatry, 2022-02, Vol.27 (2), p.1068-1074

2022

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Genetics of substance use disorders in the era of big data

Widespread signatures of positive selection in common risk alleles associated to autism spectrum disorder

ADH1B: From alcoholism, natural selection, and cancer to the human phenome

Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations

Reproducible Genetic Risk Loci for Anxiety: Results From ∼200,000 Participants in the Million Veteran Program

Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions

Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits

Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans

Phenome-wide association study of loci harboring de novo tandem repeat mutations in UK Biobank exomes

Potential causal association between leisure sedentary behaviors, physical activity and musculoskeletal health: A Mendelian randomization study

Four modifiable factors that mediate the effect of educational time on major depressive disorder risk: A network Mendelian randomization study

Causal associations of anthropometric measurements with osteoarthritis: A Mendelian randomization study

Causality of anthropometric markers associated with polycystic ovarian syndrome: Findings of a Mendelian randomization study

Causal relationships between sex hormone traits, lifestyle factors, and osteoporosis in men: A Mendelian randomization study

Not Only Gene Discovery: Genome-wide Association Studies and Polygenic Risk Scores as Tools to Dissect the Heterogeneity of Major Depressive Disorder

Not only gene discovery: genome-wide association studies and polygenic risk scoring as tools to dissect the heterogeneity of major depressive disorder

Mendelian randomization analysis of plasma levels of CD209 and MICB proteins and the risk of varicose veins of lower extremities

Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers

Genetic associations with suicide attempt severity and genetic overlap with major depression

Causal linkage between adult height and kidney function: An integrated population-scale observational analysis and Mendelian randomization study

Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium

Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells

Multi-environment gene interactions linked to the interplay between polysubstance dependence and suicidality

Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder

Psychosocial moderators of polygenic risk for suicidal ideation: Results from a 7-year population-based, prospective cohort study of U.S. veterans

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