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Regulation of Autophagy by Nuclear GAPDH and Its Aggregates in Cancer and Neurodegenerative Disorders

International journal of molecular sciences, 2019-04, Vol.20 (9), p.2062

2019

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Mutant p53-Associated Molecular Mechanisms of ROS Regulation in Cancer Cells

Biomolecules (Basel, Switzerland), 2020-02, Vol.10 (3), p.361

2020

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To metabolomics and beyond: a technological portfolio to investigate cancer metabolism

Signal transduction and targeted therapy, 2023-03, Vol.8 (1), p.137-137, Article 137

2023

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Extracellular Matrix Composition Modulates the Responsiveness of Differentiated and Stem Pancreatic Cancer Cells to Lipophilic Derivate of Gemcitabine

International journal of molecular sciences, 2020-12, Vol.22 (1), p.29

2020

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3-Bromo-Isoxazoline Derivatives Inhibit GAPDH Enzyme in PDAC Cells Triggering Autophagy and Apoptotic Cell Death

Cancers, 2022-06, Vol.14 (13), p.3153

2022

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Redox Sensitive Cysteine Residues as Crucial Regulators of Wild-Type and Mutant p53 Isoforms

Cells (Basel, Switzerland), 2021-11, Vol.10 (11), p.3149

2021

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Tumor Suppressor Role of Wild-Type P53-Dependent Secretome and Its Proteomic Identification in PDAC

Biomolecules (Basel, Switzerland), 2022-02, Vol.12 (2), p.305

2022

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Molecular interplay between mutant p53 proteins and autophagy in cancer cells

Biochimica et biophysica acta. Reviews on cancer, 2017-01, Vol.1867 (1), p.19-28

2017

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Autocrine mechanisms of cancer chemoresistance

Seminars in cell & developmental biology, 2018-06, Vol.78, p.3-12

2018

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Regulation of succinate dehydrogenase and role of succinate in cancer

Seminars in cell & developmental biology, 2020-02, Vol.98, p.4-14

2020

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Mutant p53 prevents GAPDH nuclear translocation in pancreatic cancer cells favoring glycolysis and 2-deoxyglucose sensitivity

Biochimica et biophysica acta. Molecular cell research, 2018-12, Vol.1865 (12), p.1914-1923

2018

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Mutant p53 proteins alter cancer cell secretome and tumour microenvironment: Involvement in cancer invasion and metastasis

Cancer letters, 2016-07, Vol.376 (2), p.303-309

2016

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Discovery of a spirocyclic 3-bromo-4,5-dihydroisoxazole covalent inhibitor of hGAPDH with antiproliferative activity against pancreatic cancer cells

European journal of medicinal chemistry, 2023-06, Vol.254, p.115286-115286, Article 115286

2023

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The antioxidant uncoupling protein 2 stimulates hnRNPA2/B1, GLUT1 and PKM2 expression and sensitizes pancreas cancer cells to glycolysis inhibition

Free radical biology & medicine, 2016-12, Vol.101, p.305-316

2016

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UCP2 inhibition induces ROS/Akt/mTOR axis: Role of GAPDH nuclear translocation in genipin/everolimus anticancer synergism

Free radical biology & medicine, 2017-12, Vol.113, p.176-189

2017

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Mutant p53 induces SIRT3/MnSOD axis to moderate ROS production in melanoma cells

Archives of biochemistry and biophysics, 2020-01, Vol.679, p.108219-108219, Article 108219

2020

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Trichostatin A alters cytoskeleton and energy metabolism of pancreatic adenocarcinoma cells: An in depth proteomic study

Journal of cellular biochemistry, 2018-03, Vol.119 (3), p.2696-2707

2018

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Oncometabolites in cancer aggressiveness and tumour repopulation

Biological reviews of the Cambridge Philosophical Society, 2019-08, Vol.94 (4), p.1530-1546

2019

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Do Astrocytes Collaborate with Neurons in Spreading the “Infectious” Aβ and Tau Drivers of Alzheimer’s Disease?

The Neuroscientist (Baltimore, Md.), 2015-02, Vol.21 (1), p.9-29

2015

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Mutant p53 blocks SESN1/AMPK/PGC-1α/UCP2 axis increasing mitochondrial O2ˉ· production in cancer cells

British journal of cancer, 2018-10, Vol.119 (8), p.994-1008

2018

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Calcium-sensing receptor antagonist (calcilytic) NPS 2143 specifically blocks the increased secretion of endogenous Aβ42 prompted by exogenous fibrillary or soluble Aβ25–35 in human cortical astrocytes and neurons—Therapeutic relevance to Alzheimer's disease

Biochimica et biophysica acta, 2013-10, Vol.1832 (10), p.1634-1652

2013

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Alzheimer's disease: An update of the roles of receptors, astrocytes and primary cilia (Review)

International journal of molecular medicine, 2013-01, Vol.31 (1), p.3-10

2013

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Combining immunofluorescence with in situ proximity ligation assay: a novel imaging approach to monitor protein–protein interactions in relation to subcellular localization

Histochemistry and cell biology, 2014-11, Vol.142 (5), p.593-600

2014

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The Aβ Peptides-Activated Calcium-Sensing Receptor Stimulates the Production and Secretion of Vascular Endothelial Growth Factor-A by Normoxic Adult Human Cortical Astrocytes

Neuromolecular medicine, 2014-12, Vol.16 (4), p.645-657

2014

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The calcium-sensing receptor: A novel Alzheimer's disease crucial target?

Journal of the neurological sciences, 2012-11, Vol.322 (1), p.137-140

2012

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Regulation of Autophagy by Nuclear GAPDH and Its Aggregates in Cancer and Neurodegenerative Disorders

Mutant p53-Associated Molecular Mechanisms of ROS Regulation in Cancer Cells

To metabolomics and beyond: a technological portfolio to investigate cancer metabolism

Extracellular Matrix Composition Modulates the Responsiveness of Differentiated and Stem Pancreatic Cancer Cells to Lipophilic Derivate of Gemcitabine

3-Bromo-Isoxazoline Derivatives Inhibit GAPDH Enzyme in PDAC Cells Triggering Autophagy and Apoptotic Cell Death

Redox Sensitive Cysteine Residues as Crucial Regulators of Wild-Type and Mutant p53 Isoforms

Tumor Suppressor Role of Wild-Type P53-Dependent Secretome and Its Proteomic Identification in PDAC

Molecular interplay between mutant p53 proteins and autophagy in cancer cells

Autocrine mechanisms of cancer chemoresistance

Regulation of succinate dehydrogenase and role of succinate in cancer

Mutant p53 prevents GAPDH nuclear translocation in pancreatic cancer cells favoring glycolysis and 2-deoxyglucose sensitivity

Mutant p53 proteins alter cancer cell secretome and tumour microenvironment: Involvement in cancer invasion and metastasis

Discovery of a spirocyclic 3-bromo-4,5-dihydroisoxazole covalent inhibitor of hGAPDH with antiproliferative activity against pancreatic cancer cells

The antioxidant uncoupling protein 2 stimulates hnRNPA2/B1, GLUT1 and PKM2 expression and sensitizes pancreas cancer cells to glycolysis inhibition

UCP2 inhibition induces ROS/Akt/mTOR axis: Role of GAPDH nuclear translocation in genipin/everolimus anticancer synergism

Mutant p53 induces SIRT3/MnSOD axis to moderate ROS production in melanoma cells

Trichostatin A alters cytoskeleton and energy metabolism of pancreatic adenocarcinoma cells: An in depth proteomic study

Oncometabolites in cancer aggressiveness and tumour repopulation

Do Astrocytes Collaborate with Neurons in Spreading the “Infectious” Aβ and Tau Drivers of Alzheimer’s Disease?

Mutant p53 blocks SESN1/AMPK/PGC-1α/UCP2 axis increasing mitochondrial O2ˉ· production in cancer cells

Calcium-sensing receptor antagonist (calcilytic) NPS 2143 specifically blocks the increased secretion of endogenous Aβ42 prompted by exogenous fibrillary or soluble Aβ25–35 in human cortical astrocytes and neurons—Therapeutic relevance to Alzheimer's disease

Alzheimer's disease: An update of the roles of receptors, astrocytes and primary cilia (Review)

Combining immunofluorescence with in situ proximity ligation assay: a novel imaging approach to monitor protein–protein interactions in relation to subcellular localization

The Aβ Peptides-Activated Calcium-Sensing Receptor Stimulates the Production and Secretion of Vascular Endothelial Growth Factor-A by Normoxic Adult Human Cortical Astrocytes

The calcium-sensing receptor: A novel Alzheimer's disease crucial target?

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