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Rapid development of colitis in NSAID-treated IL-10–deficient mice

Gastroenterology (New York, N.Y. 1943), 2002-11, Vol.123 (5), p.1527-1542

2002

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Antiproliferative effect of nonsteroidal antiinflammatory drugs against human colon cancer cells

Cancer epidemiology, biomarkers & prevention, 1994-07, Vol.3 (5), p.433-438

1994

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Exisulind induction of apoptosis involves guanosine 3', 5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated β-catenin

Cancer research (Chicago, Ill.), 2000-07, Vol.60 (13), p.3338-3342

2000

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A K-ras oncogene increases resistance to sulindac-induced apoptosis in rat enterocytes

Gastroenterology (New York, N.Y. 1943), 1997-12, Vol.113 (6), p.1892-1900

1997

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Cyclic GMP-dependent protein kinase activation and induction by exisulind and CP461 in colon tumor cells

The Journal of pharmacology and experimental therapeutics, 2001-11, Vol.299 (2), p.583

2001

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Cyclic GMP Mediates Apoptosis Induced by Sulindac Derivatives via Activation of c-Jun NH2-Terminal Kinase 1

Clinical cancer research, 2000-10, Vol.6 (10), p.4136-4141

2000

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Sulindac derivatives inhibit growth and induce apoptosis in human prostate cancer cell lines

Biochemical pharmacology, 1999-10, Vol.58 (7), p.1097-1107

1999

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Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels

Cancer research (Chicago, Ill.), 1997-07, Vol.57 (14), p.2909-2915

1997

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Apoptosis primarily accounts for the growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxygenase inhibition, cell cycle arrest, and p53 induction

Cancer research (Chicago, Ill.), 1997-06, Vol.57 (12), p.2452-2459

1997

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β-Catenin Signaling: Therapeutic Strategies in Oncology

Cancer biology & therapy, 2002-11, Vol.1 (6), p.621-625

2002

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Protein Kinase G Activates the JNK1 Pathway via Phosphorylation of MEKK1

The Journal of biological chemistry, 2001-05, Vol.276 (19), p.16406-16410

2001

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Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis

Cancer research (Chicago, Ill.), 1995-07, Vol.55 (14), p.3110-3116

1995

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Exisulind, a novel proapoptotic drug, inhibits rat urinary bladder tumorigenesis

Cancer research (Chicago, Ill.), 2001-05, Vol.61 (10), p.3961-3968

2001

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Exisulind (sulindac sulfone) suppresses growth of human prostate cancer in a nude mouse xenograft model by increasing apoptosis

Urology (Ridgewood, N.J.), 1999-02, Vol.53 (2), p.440-445

1999

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Sulfone metabolite of sulindac inhibits mammary carcinogenesis

Cancer research (Chicago, Ill.), 1997-01, Vol.57 (2), p.267-271

1997

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Exisulind in Combination with Docetaxel Inhibits Growth and Metastasis of Human Lung Cancer and Prolongs Survival in Athymic Nude Rats with Orthotopic Lung Tumors

Clinical cancer research, 2002-03, Vol.8 (3), p.904-912

2002

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Pro-apoptotic actions of exisulind and CP461 in SW480 colon tumor cells involve β-catenin and cyclin D1 down-regulation

Biochemical pharmacology, 2002-11, Vol.64 (9), p.1325-1336

2002

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Vasodilator-stimulated phosphoprotein (VASP) phosphorylation provides a biomarker for the action of exisulind and related agents that activate protein kinase G

Molecular cancer therapeutics, 2002-08, Vol.1 (10), p.803-809

2002

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Exisulind and Related Compounds Inhibit Expression and Function of the Androgen Receptor in Human Prostate Cancer Cells

Clinical cancer research, 2003-10, Vol.9 (13), p.4972-4982

2003

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Specific cGMP binding by the cGMP binding domains of cGMP-binding cGMP specific phosphodiesterase

Cellular signalling, 2002, Vol.14 (1), p.45-51

2002

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Inhibition of angiogenesis by sulindac and its sulfone metabolite (FGN-1): a potential mechanism for their antineoplastic properties

International journal on tissue reactions, 1998, Vol.20 (3), p.85

1998

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Determination of FGN-1 (an active metabolite of sulindac) in human plasma, urine, and feces by HPLC

Journal of pharmaceutical and biomedical analysis, 1995-12, Vol.14 (1), p.213-220

1995

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Proapoptotic anti-inflammatory drugs

Urology (Ridgewood, N.J.), 2001-04, Vol.57 (4), p.73-76

2001

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Effects of sulindac and its metabolites on growth and apoptosis in human mammary epithelial and breast carcinoma cell lines

Breast cancer research and treatment, 1998-04, Vol.48 (3), p.195-203

1998

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Do NSAIDs exert their colon cancer chemoprevention activities through the inhibition of mucosal prostaglandin synthetase?

Journal of cellular biochemistry, 1995, Vol.59 (S22), p.18-23

1995

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Rapid development of colitis in NSAID-treated IL-10–deficient mice

Antiproliferative effect of nonsteroidal antiinflammatory drugs against human colon cancer cells

Exisulind induction of apoptosis involves guanosine 3', 5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated β-catenin

A K-ras oncogene increases resistance to sulindac-induced apoptosis in rat enterocytes

Cyclic GMP-dependent protein kinase activation and induction by exisulind and CP461 in colon tumor cells

Cyclic GMP Mediates Apoptosis Induced by Sulindac Derivatives via Activation of c-Jun NH2-Terminal Kinase 1

Sulindac derivatives inhibit growth and induce apoptosis in human prostate cancer cell lines

Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels

Apoptosis primarily accounts for the growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxygenase inhibition, cell cycle arrest, and p53 induction

β-Catenin Signaling: Therapeutic Strategies in Oncology

Protein Kinase G Activates the JNK1 Pathway via Phosphorylation of MEKK1

Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis

Exisulind, a novel proapoptotic drug, inhibits rat urinary bladder tumorigenesis

Exisulind (sulindac sulfone) suppresses growth of human prostate cancer in a nude mouse xenograft model by increasing apoptosis

Sulfone metabolite of sulindac inhibits mammary carcinogenesis

Exisulind in Combination with Docetaxel Inhibits Growth and Metastasis of Human Lung Cancer and Prolongs Survival in Athymic Nude Rats with Orthotopic Lung Tumors

Pro-apoptotic actions of exisulind and CP461 in SW480 colon tumor cells involve β-catenin and cyclin D1 down-regulation

Vasodilator-stimulated phosphoprotein (VASP) phosphorylation provides a biomarker for the action of exisulind and related agents that activate protein kinase G

Exisulind and Related Compounds Inhibit Expression and Function of the Androgen Receptor in Human Prostate Cancer Cells

Specific cGMP binding by the cGMP binding domains of cGMP-binding cGMP specific phosphodiesterase

Inhibition of angiogenesis by sulindac and its sulfone metabolite (FGN-1): a potential mechanism for their antineoplastic properties

Determination of FGN-1 (an active metabolite of sulindac) in human plasma, urine, and feces by HPLC

Proapoptotic anti-inflammatory drugs

Effects of sulindac and its metabolites on growth and apoptosis in human mammary epithelial and breast carcinoma cell lines

Do NSAIDs exert their colon cancer chemoprevention activities through the inhibition of mucosal prostaglandin synthetase?

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