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Differential Activity of ATR and WEE1 Inhibitors in a Highly Sensitive Subpopulation of DLBCL Linked to Replication Stress

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (14), p.3762-3775

2019

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Optimizing Therapeutic Effect of Aurora B Inhibition in Acute Myeloid Leukemia with AZD2811 Nanoparticles

Molecular cancer therapeutics, 2017-06, Vol.16 (6), p.1031-1040

2017

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AZD1152, a Selective Inhibitor of Aurora B Kinase, Inhibits Human Tumor Xenograft Growth by Inducing Apoptosis

Clinical cancer research, 2007-06, Vol.13 (12), p.3682-3688

2007

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Atomic layer deposition of TaN and Ta3N5 using pentakis(dimethylamino) tantalum and either ammonia or monomethylhydrazine

Journal of crystal growth, 2011-09, Vol.331 (1), p.33-39

2011

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The Solid-State Structures of Dimethylzinc and Diethylzinc

Angewandte Chemie (International ed.), 2011-12, Vol.50 (49), p.11685-11687

International ed. in English, 2011

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AZD1152 Rapidly and Negatively Affects the Growth and Survival of Human Acute Myeloid Leukemia Cells In vitro and In vivo

Cancer research (Chicago, Ill.), 2009-05, Vol.69 (10), p.4150-4158

2009

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Preclinical evaluation of M30 and M65 ELISAs as biomarkers of drug induced tumor cell death and antitumor activity

Molecular cancer therapeutics, 2008-03, Vol.7 (3), p.455-463

2008

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Abstract 3343: The pre-clinical in vitro and in vivo activity of AZD6738: A potent and selective inhibitor of ATR kinase

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.3343-3343

2013

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Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Kinase with Application as an Anticancer Agent

Journal of medicinal chemistry, 2018-11, Vol.61 (22), p.9889-9907

2018

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ATR Inhibitor AZD6738 (Ceralasertib) Exerts Antitumor Activity as a Monotherapy and in Combination with Chemotherapy and the PARP Inhibitor Olaparib

Cancer research (Chicago, Ill.), 2022-03, Vol.82 (6), p.1140-1152

2022

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Pharmacokinetics-Pharmacodynamics of Enmetazobactam Combined with Cefepime in a Neutropenic Murine Thigh Infection Model

Antimicrobial agents and chemotherapy, 2020-05, Vol.64 (6)

2020

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Thermal gas-phase etching of titanium nitride (TiN) by thionyl chloride (SOCl2)

Applied surface science, 2021-02, Vol.540, p.148309, Article 148309

2021

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Discovery of 4‑{4-[(3R)‑3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}‑1H‑indole (AZ20): A Potent and Selective Inhibitor of ATR Protein Kinase with Monotherapy in Vivo Antitumor Activity

Journal of medicinal chemistry, 2013-03, Vol.56 (5), p.2125-2138

2013

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Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo

Science translational medicine, 2016-02, Vol.8 (325), p.325ra17

2016

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The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models

Cancer research (Chicago, Ill.), 2016-10, Vol.76 (20), p.6084-6094

2016

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Discovery of Novel UDP‑N‑Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa

Journal of medicinal chemistry, 2021-10, Vol.64 (19), p.14377-14425

2021

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pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry

British journal of cancer, 2018-11, Vol.119 (10), p.1233-1243

2018

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The Solid-State Structures of Dimethylzinc and Diethylzinc

Angewandte Chemie, 2011-12, Vol.123 (49), p.11889-11891

2011

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Abstract 2494: ATR inhibitor AZD6738 as monotherapy and in combination with olaparib or chemotherapy: defining pre-clinical dose-schedules and efficacy modelling

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.2494-2494

2017

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Ce(IV) Complexes with Donor-Functionalized Alkoxide Ligands: Improved Precursors for Chemical Vapor Deposition of CeO2

Inorganic chemistry, 2011-11, Vol.50 (22), p.11644-11652

2011

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Abstract 4524: A preclinical PKPD modeling & simulation strategy: building a predictive model of dose, schedule and therapeutic index for small molecule targeted anticancer agents

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.4524-4524

2015

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Abstract C60: Pre-clinical efficacy of the ATR inhibitor AZD6738 in combination with the PARP inhibitor olaparib

Molecular cancer therapeutics, 2015-12, Vol.14 (12_Supplement_2), p.C60-C60

2015

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Abstract B32: CRLX101, an investigational camptothecin-containing nanoparticle-drug conjugate, combined with DDR agents provides a novel approach to increasing therapeutic index

Molecular cancer research, 2017-04, Vol.15 (4_Supplement), p.B32-B32

2017

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Differential Activity of ATR and WEE1 Inhibitors in a Highly Sensitive Subpopulation of DLBCL Linked to Replication Stress

Orally Bioavailable and Blood-Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice

Optimizing Therapeutic Effect of Aurora B Inhibition in Acute Myeloid Leukemia with AZD2811 Nanoparticles

AZD1152, a Selective Inhibitor of Aurora B Kinase, Inhibits Human Tumor Xenograft Growth by Inducing Apoptosis

Atomic layer deposition of TaN and Ta3N5 using pentakis(dimethylamino) tantalum and either ammonia or monomethylhydrazine

The Solid-State Structures of Dimethylzinc and Diethylzinc

Discovery, Synthesis, and in Vivo Activity of a New Class of Pyrazoloquinazolines as Selective Inhibitors of Aurora B Kinase

AZD1152 Rapidly and Negatively Affects the Growth and Survival of Human Acute Myeloid Leukemia Cells In vitro and In vivo

Preclinical evaluation of M30 and M65 ELISAs as biomarkers of drug induced tumor cell death and antitumor activity

Abstract 3343: The pre-clinical in vitro and in vivo activity of AZD6738: A potent and selective inhibitor of ATR kinase

Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Kinase with Application as an Anticancer Agent

ATR Inhibitor AZD6738 (Ceralasertib) Exerts Antitumor Activity as a Monotherapy and in Combination with Chemotherapy and the PARP Inhibitor Olaparib

Pharmacokinetics-Pharmacodynamics of Enmetazobactam Combined with Cefepime in a Neutropenic Murine Thigh Infection Model

Thermal gas-phase etching of titanium nitride (TiN) by thionyl chloride (SOCl2)

Discovery of 4‑{4-[(3R)‑3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}‑1H‑indole (AZ20): A Potent and Selective Inhibitor of ATR Protein Kinase with Monotherapy in Vivo Antitumor Activity

Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo

The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models

Discovery of Novel UDP‑N‑Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa

pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry

The Solid-State Structures of Dimethylzinc and Diethylzinc

Abstract 2494: ATR inhibitor AZD6738 as monotherapy and in combination with olaparib or chemotherapy: defining pre-clinical dose-schedules and efficacy modelling

Ce(IV) Complexes with Donor-Functionalized Alkoxide Ligands: Improved Precursors for Chemical Vapor Deposition of CeO2

Abstract 4524: A preclinical PKPD modeling & simulation strategy: building a predictive model of dose, schedule and therapeutic index for small molecule targeted anticancer agents

Abstract C60: Pre-clinical efficacy of the ATR inhibitor AZD6738 in combination with the PARP inhibitor olaparib

Abstract B32: CRLX101, an investigational camptothecin-containing nanoparticle-drug conjugate, combined with DDR agents provides a novel approach to increasing therapeutic index

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