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Galectin-8 inhibition and functions in immune response and tumor biology

Medicinal research reviews, 2024-04

2024

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Protein Flexibility and Conformational Entropy in Ligand Design Targeting the Carbohydrate Recognition Domain of Galectin-3

Journal of the American Chemical Society, 2010-10, Vol.132 (41), p.14577-14589

2010

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The Carbohydrate-Binding Site in Galectin-3 Is Preorganized To Recognize a Sugarlike Framework of Oxygens: Ultra-High-Resolution Structures and Water Dynamics

Biochemistry (Easton), 2012-01, Vol.51 (1), p.296-306

2012

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Interplay between Conformational Entropy and Solvation Entropy in Protein–Ligand Binding

Journal of the American Chemical Society, 2019-02, Vol.141 (5), p.2012-2026

2019

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Novel Selective Galectin‑3 Antagonists Are Cytotoxic to Acute Lymphoblastic Leukemia

Journal of medicinal chemistry, 2022-04, Vol.65 (8), p.5975-5989

2022

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Direct sialic acid 4-OAc substitution by nitrogen, sulfur and carbon nucleophiles with retention of stereochemistry

RSC advances, 2022-04, Vol.12 (19), p.11992-11995

2022

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Regulation of Transforming Growth Factor-β1-driven Lung Fibrosis by Galectin-3

American journal of respiratory and critical care medicine, 2012-03, Vol.185 (5), p.537-546

2012

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Regulation of Alternative Macrophage Activation by Galectin-3

The Journal of immunology (1950), 2008-02, Vol.180 (4), p.2650-2658

2008

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Ligand Induced Galectin-3 Protein Self-association

The Journal of biological chemistry, 2012-06, Vol.287 (26), p.21751-21756

2012

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Structural characterisation of human galectin-4 N-terminal carbohydrate recognition domain in complex with glycerol, lactose, 3'-sulfo-lactose, and 2'-fucosyllactose

Scientific reports, 2016-02, Vol.6 (1), p.20289-20289, Article 20289

2016

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Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition

Chembiochem : a European journal of chemical biology, 2016-09, Vol.17 (18), p.1759-1770

2016

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Extracellular and intracellular small-molecule galectin-3 inhibitors

Scientific reports, 2019-02, Vol.9 (1), p.2186, Article 2186

2019

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Low or No Inhibitory Potency of the Canonical Galectin Carbohydrate-binding Site by Pectins and Galactomannans

The Journal of biological chemistry, 2016-06, Vol.291 (25), p.13318-13334

2016

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Regulation of Transforming Growth Factor-beta 1-driven Lung Fibrosis by Galectin-3

American journal of respiratory and critical care medicine, 2012-03, Vol.185 (5), p.537

2012

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Galectin-3 Inhibition by a Small-Molecule Inhibitor Reduces Both Pathological Corneal Neovascularization and Fibrosis

Investigative ophthalmology & visual science, 2017-01, Vol.58 (1), p.9-20

2017

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Hydrophobic ion pairing of a minocycline/Ca(2+)/AOT complex for preparation of drug-loaded PLGA nanoparticles with improved sustained release

International journal of pharmaceutics, 2016-02, Vol.499 (1-2), p.351-357

2016

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Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis

The European respiratory journal, 2021-05, Vol.57 (5), p.2002559

2021

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Double Affinity Amplification of Galectin-Ligand Interactions through Arginine-Arene Interactions: Synthetic, Thermodynamic, and Computational Studies with Aromatic Diamido Thiodigalactosides

Chemistry : a European journal, 2008-01, Vol.14 (14), p.4233-4245

2008

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Galectin-8 Downmodulates TLR4 Activation and Impairs Bacterial Clearance in a Mouse Model of Pseudomonas aeruginosa Keratitis

The Journal of immunology (1950), 2023-02, Vol.210 (4), p.398-407

2023

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1H-1,2,3-Triazol-1-yl thiodigalactoside derivatives as high affinity galectin-3 inhibitors

Bioorganic & medicinal chemistry, 2010-07, Vol.18 (14), p.5367-5378

2010

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Sialic Acid 4‐N‐Piperazine and Piperidine Derivatives Bind with High Affinity to the P. mirabilis Sialic Acid Sodium Solute Symporter

ChemMedChem, 2022-12, Vol.17 (23), p.e202200351-n/a

2022

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Entropy–Entropy Compensation between the Protein, Ligand, and Solvent Degrees of Freedom Fine-Tunes Affinity in Ligand Binding to Galectin-3C

JACS Au, 2021-04, Vol.1 (4), p.484-500

2021

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The glomerular endothelial cell coat is essential for glomerular filtration

Kidney international, 2011-06, Vol.79 (12), p.1322-1330

2011

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Hydrophobic ion pairing of a minocycline/Ca2+/AOT complex for preparation of drug-loaded PLGA nanoparticles with improved sustained release

International journal of pharmaceutics, 2016-02, Vol.499 (1-2), p.351-357

2016

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Galectin-8 inhibition and functions in immune response and tumor biology

Protein Flexibility and Conformational Entropy in Ligand Design Targeting the Carbohydrate Recognition Domain of Galectin-3

The Carbohydrate-Binding Site in Galectin-3 Is Preorganized To Recognize a Sugarlike Framework of Oxygens: Ultra-High-Resolution Structures and Water Dynamics

Interplay between Conformational Entropy and Solvation Entropy in Protein–Ligand Binding

Novel Selective Galectin‑3 Antagonists Are Cytotoxic to Acute Lymphoblastic Leukemia

Direct sialic acid 4-OAc substitution by nitrogen, sulfur and carbon nucleophiles with retention of stereochemistry

Regulation of Transforming Growth Factor-β1-driven Lung Fibrosis by Galectin-3

Regulation of Alternative Macrophage Activation by Galectin-3

Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer’s disease

Ligand Induced Galectin-3 Protein Self-association

Structural characterisation of human galectin-4 N-terminal carbohydrate recognition domain in complex with glycerol, lactose, 3'-sulfo-lactose, and 2'-fucosyllactose

Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition

Extracellular and intracellular small-molecule galectin-3 inhibitors

Low or No Inhibitory Potency of the Canonical Galectin Carbohydrate-binding Site by Pectins and Galactomannans

Regulation of Transforming Growth Factor-beta 1-driven Lung Fibrosis by Galectin-3

Galectin-3 Inhibition by a Small-Molecule Inhibitor Reduces Both Pathological Corneal Neovascularization and Fibrosis

Hydrophobic ion pairing of a minocycline/Ca(2+)/AOT complex for preparation of drug-loaded PLGA nanoparticles with improved sustained release

Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis

Double Affinity Amplification of Galectin-Ligand Interactions through Arginine-Arene Interactions: Synthetic, Thermodynamic, and Computational Studies with Aromatic Diamido Thiodigalactosides

Galectin-8 Downmodulates TLR4 Activation and Impairs Bacterial Clearance in a Mouse Model of Pseudomonas aeruginosa Keratitis

1H-1,2,3-Triazol-1-yl thiodigalactoside derivatives as high affinity galectin-3 inhibitors

Sialic Acid 4‐N‐Piperazine and Piperidine Derivatives Bind with High Affinity to the P. mirabilis Sialic Acid Sodium Solute Symporter

Entropy–Entropy Compensation between the Protein, Ligand, and Solvent Degrees of Freedom Fine-Tunes Affinity in Ligand Binding to Galectin-3C

The glomerular endothelial cell coat is essential for glomerular filtration

Hydrophobic ion pairing of a minocycline/Ca2+/AOT complex for preparation of drug-loaded PLGA nanoparticles with improved sustained release

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