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Technologies for Direct Detection of Covalent Protein-Drug Adducts

Pharmaceuticals (Basel, Switzerland), 2023-04, Vol.16 (4), p.547

2023

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Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly

Nature (London), 2021-02, Vol.590 (7847), p.671-676

2021

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Exploring the Versatility of the Covalent Thiol–Alkyne Reaction with Substituted Propargyl Warheads: A Deciding Role for the Cysteine Protease

Journal of the American Chemical Society, 2021-05, Vol.143 (17), p.6423-6433

2021

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Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5

Nature chemical biology, 2024-02, Vol.20 (2), p.190

2024

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A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes

Nature chemical biology, 2016-07, Vol.12 (7), p.523

2016

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Total Chemical Synthesis of SUMO and SUMO‐Based Probes for Profiling the Activity of SUMO‐Specific Proteases

Angewandte Chemie (International ed.), 2018-07, Vol.57 (29), p.8958-8962

International ed. in English, 2018

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A high-field cellular DNP-supported solid-state NMR approach to study proteins with sub-cellular specificity

Chemical science (Cambridge), 2023-09, Vol.14 (36), p.9892-9899

2023

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Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity

Nature communications, 2019-01, Vol.10 (1), p.231-231, Article 231

2019

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Generation of the UFM1 Toolkit for Profiling UFM1‐Specific Proteases and Ligases

Angewandte Chemie (International ed.), 2018-10, Vol.57 (43), p.14164-14168

International ed. in English, 2018

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Hybrid Chains: A Collaboration of Ubiquitin and Ubiquitin-Like Modifiers Introducing Cross-Functionality to the Ubiquitin Code

Frontiers in chemistry, 2020-01, Vol.7, p.931-931

2020

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Synthesis and evaluation of novel macrocyclic antifungal peptides

Bioorganic & medicinal chemistry, 2011-11, Vol.19 (21), p.6505-6517

2011

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Targeting TRIM Proteins: A Quest towards Drugging an Emerging Protein Class

Chembiochem : a European journal of chemical biology, 2021-06, Vol.22 (12), p.2011-2031

2021

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Expanding Chemical Probe Space: Quality Criteria for Covalent and Degrader Probes

Journal of medicinal chemistry, 2023-07, Vol.66 (14), p.9297-9312

2023

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Plate-Based Screening for DUB Inhibitors

Methods in molecular biology (Clifton, N.J.), 2023, Vol.2706, p.89

2023

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Editorial: Probing the Ubiquitin Landscape

Frontiers in chemistry, 2020-05, Vol.8, p.449-449

2020

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Ubiquitin Phosphorylation at Thr12 Modulates the DNA Damage Response

Molecular cell, 2020-11, Vol.80 (3), p.423-436.e9

2020

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Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne

Nature (London), 2016-10, Vol.538 (7625), p.402-405

2016

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Cracking the Ubiquitin Code: The Ubiquitin Toolbox

Current issues in molecular biology, 2020, Vol.37, p.1-20

2020

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A Native Chemical Ligation Handle that Enables the Synthesis of Advanced Activity-Based Probes: Diubiquitin as a Case Study

Chembiochem : a European journal of chemical biology, 2014-05, Vol.15 (7), p.946-949

2014

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Strategy for Development of Site-Specific Ubiquitin Antibodies

Frontiers in chemistry, 2020-02, Vol.8, p.111-111

2020

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Advancing our Understanding of Ubiquitination Using the Ub-Toolkit

Journal of molecular biology, 2017-11, Vol.429 (22), p.3388-3394

2017

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Highly Specialized Ubiquitin-Like Modifications: Shedding Light into the UFM1 Enigma

Biomolecules (Basel, Switzerland), 2021-02, Vol.11 (2), p.255

2021

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A Pro‐Fluorescent Ubiquitin‐Based Probe to Monitor Cysteine‐Based E3 Ligase Activity

Angewandte Chemie (International ed.), 2023-08, Vol.62 (32), p.e202303319-n/a

International ed. in English, 2023

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SUMOylation and the HSF1-Regulated Chaperone Network Converge to Promote Proteostasis in Response to Heat Shock

Cell reports (Cambridge), 2019-01, Vol.26 (1), p.236-249.e4

2019

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Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies

Scientific reports, 2018-01, Vol.8 (1), p.1405-15, Article 1405

2018

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Technologies for Direct Detection of Covalent Protein-Drug Adducts

Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly

Exploring the Versatility of the Covalent Thiol–Alkyne Reaction with Substituted Propargyl Warheads: A Deciding Role for the Cysteine Protease

Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5

A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes

Total Chemical Synthesis of SUMO and SUMO‐Based Probes for Profiling the Activity of SUMO‐Specific Proteases

A high-field cellular DNP-supported solid-state NMR approach to study proteins with sub-cellular specificity

Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity

Generation of the UFM1 Toolkit for Profiling UFM1‐Specific Proteases and Ligases

Hybrid Chains: A Collaboration of Ubiquitin and Ubiquitin-Like Modifiers Introducing Cross-Functionality to the Ubiquitin Code

Synthesis and evaluation of novel macrocyclic antifungal peptides

Targeting TRIM Proteins: A Quest towards Drugging an Emerging Protein Class

Expanding Chemical Probe Space: Quality Criteria for Covalent and Degrader Probes

Plate-Based Screening for DUB Inhibitors

Editorial: Probing the Ubiquitin Landscape

Ubiquitin Phosphorylation at Thr12 Modulates the DNA Damage Response

Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne

Cracking the Ubiquitin Code: The Ubiquitin Toolbox

A Native Chemical Ligation Handle that Enables the Synthesis of Advanced Activity-Based Probes: Diubiquitin as a Case Study

Strategy for Development of Site-Specific Ubiquitin Antibodies

Advancing our Understanding of Ubiquitination Using the Ub-Toolkit

Highly Specialized Ubiquitin-Like Modifications: Shedding Light into the UFM1 Enigma

A Pro‐Fluorescent Ubiquitin‐Based Probe to Monitor Cysteine‐Based E3 Ligase Activity

SUMOylation and the HSF1-Regulated Chaperone Network Converge to Promote Proteostasis in Response to Heat Shock

Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies

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